Global profiling of arginine reactivity and ligandability in the human proteome.

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Title: Global profiling of arginine reactivity and ligandability in the human proteome.
Authors: Wang Y; Institute of Chemical Biology, Shenzhen Bay Laboratory, Shenzhen, China.; College of Bee Science and Biomedicine, Fujian Agriculture and Forest University, Fuzhou, China., Hu T; Institute of Chemical Biology, Shenzhen Bay Laboratory, Shenzhen, China.; State Key Laboratory for Crop Stress Resistance and High-Efficiency Production, College of Life Sciences, Northwest A & F University, Yangling, China., Zhu L; Institute of Chemical Biology, Shenzhen Bay Laboratory, Shenzhen, China.; Department of Chemistry and State Key Laboratory of Synthetic Chemistry, The University of Hong Kong, Hong Kong SAR, China., Xie S; Institute of Chemical Biology, Shenzhen Bay Laboratory, Shenzhen, China., Yang X; Institute of Chemical Biology, Shenzhen Bay Laboratory, Shenzhen, China., Xu C; Institute of Chemical Biology, Shenzhen Bay Laboratory, Shenzhen, China., Zhai Y; Institute of Chemical Biology, Shenzhen Bay Laboratory, Shenzhen, China., Li Y; Institute of Chemical Biology, Shenzhen Bay Laboratory, Shenzhen, China.; School of Information and Software Engineering, University of Electronic Science and Technology of China, Chengdu, China., Huang X; Institute of Chemical Biology, Shenzhen Bay Laboratory, Shenzhen, China., Yang B; State Key Laboratory for Crop Stress Resistance and High-Efficiency Production, College of Life Sciences, Northwest A & F University, Yangling, China., Li G; Institute of Chemical Biology, Shenzhen Bay Laboratory, Shenzhen, China. ligang@szbl.ac.cn.
Source: Nature chemistry [Nat Chem] 2026 Feb; Vol. 18 (2), pp. 374-385. Date of Electronic Publication: 2026 Jan 02.
Publication Type: Journal Article; Research Support, Non-U.S. Gov't
Journal Info: Publisher: Nature Pub. Group Country of Publication: England NLM ID: 101499734 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1755-4349 (Electronic) Linking ISSN: 17554330 NLM ISO Abbreviation: Nat Chem Subsets: MEDLINE
Database: MEDLINE Ultimate
Description
ISSN:1755-4349
DOI:10.1038/s41557-025-02012-6