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Tight junction-high and CDH17-positive cell population is the source of colorectal cancer liver metastases.

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Title: Tight junction-high and CDH17-positive cell population is the source of colorectal cancer liver metastases.
Authors: Alvarez-Villanueva D; Cancer Research Program, Hospital del Mar Research Institute, Barcelona, Spain.; Chemoresistance and Predictive Factors Group, Program Against Cancer Therapeutic Resistance (ProCURE), Catalan Institute of Oncology (ICO), Oncobell Program, Bellvitge Biomedical Research Institute (IDIBELL), L'Hospitalet del Llobregat, Barcelona, Spain., Maqueda M; Cancer Research Program, Hospital del Mar Research Institute, Barcelona, Spain., Harti D; Cancer Research Program, Hospital del Mar Research Institute, Barcelona, Spain., Canton E; Cancer Research Program, Hospital del Mar Research Institute, Barcelona, Spain.; Josep Carreras Leukemia Research Institute, Badalona, Spain., Andrades E; Dermatology Department, Hospital del Mar, Barcelona, Spain., Bertran J; Faculty of Sciences, Technology and Engineering, Universitat de Vic - Universitat Central de Catalunya, Barcelona, Spain., Martínez-Iniesta M; Chemoresistance and Predictive Factors Group, Program Against Cancer Therapeutic Resistance (ProCURE), Catalan Institute of Oncology (ICO), Oncobell Program, Bellvitge Biomedical Research Institute (IDIBELL), L'Hospitalet del Llobregat, Barcelona, Spain., Solé L; Cancer Research Program, Hospital del Mar Research Institute, Barcelona, Spain.; Centro de Investigación Biomédica en Red Cáncer (CIBERONC), Madrid, Spain., García-Hernández V; Cancer Research Program, Hospital del Mar Research Institute, Barcelona, Spain., Montoto Á; Cancer Research Program, Hospital del Mar Research Institute, Barcelona, Spain., Lobo-Jarne T; Cancer Research Program, Hospital del Mar Research Institute, Barcelona, Spain., Alonso-Marañón J; Cancer Research Program, Hospital del Mar Research Institute, Barcelona, Spain., Herrero-Molinero P; Cancer Research Program, Hospital del Mar Research Institute, Barcelona, Spain., Larrubia-Loring M; Pathology Department, Hospital del Mar, Barcelona, Spain., Tramuns A; Pathology Department, Hospital del Mar, Barcelona, Spain., Wynne K; Systems Biology Ireland, School of Medicine, University College Dublin, Belfield, Dublin, Ireland.; Conway Institute of Biomolecular and Biomedical Research, University College Dublin, Belfield, Ireland., Bera I; Conway Institute of Biomolecular and Biomedical Research, University College Dublin, Belfield, Ireland., Matallanas D; Conway Institute of Biomolecular and Biomedical Research, University College Dublin, Belfield, Ireland., Villanueva A; Chemoresistance and Predictive Factors Group, Program Against Cancer Therapeutic Resistance (ProCURE), Catalan Institute of Oncology (ICO), Oncobell Program, Bellvitge Biomedical Research Institute (IDIBELL), L'Hospitalet del Llobregat, Barcelona, Spain., Bigas A; Cancer Research Program, Hospital del Mar Research Institute, Barcelona, Spain.; Josep Carreras Leukemia Research Institute, Badalona, Spain.; Centro de Investigación Biomédica en Red Cáncer (CIBERONC), Madrid, Spain., Iglesias M; Centro de Investigación Biomédica en Red Cáncer (CIBERONC), Madrid, Spain.; Pathology Department, Hospital del Mar, Barcelona, Spain.; Universitat Pompeu Fabra (UPF), Barcelona, Spain., Espinosa L; Cancer Research Program, Hospital del Mar Research Institute, Barcelona, Spain. lespinosa@researchmar.net.; Centro de Investigación Biomédica en Red Cáncer (CIBERONC), Madrid, Spain. lespinosa@researchmar.net.
Source: Nature communications [Nat Commun] 2026 Jan 03; Vol. 17 (1), pp. 1425. Date of Electronic Publication: 2026 Jan 03.
Publication Type: Journal Article
Journal Info: Publisher: Nature Pub. Group Country of Publication: England NLM ID: 101528555 Publication Model: Electronic Cited Medium: Internet ISSN: 2041-1723 (Electronic) Linking ISSN: 20411723 NLM ISO Abbreviation: Nat Commun Subsets: MEDLINE
Database: MEDLINE Ultimate
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  Data: Tight junction-high and CDH17-positive cell population is the source of colorectal cancer liver metastases.
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  Data: <searchLink fieldCode="AU" term="%22Alvarez-Villanueva+D%22">Alvarez-Villanueva D</searchLink>; Cancer Research Program, Hospital del Mar Research Institute, Barcelona, Spain.; Chemoresistance and Predictive Factors Group, Program Against Cancer Therapeutic Resistance (ProCURE), Catalan Institute of Oncology (ICO), Oncobell Program, Bellvitge Biomedical Research Institute (IDIBELL), L'Hospitalet del Llobregat, Barcelona, Spain.<br /><searchLink fieldCode="AU" term="%22Maqueda+M%22">Maqueda M</searchLink>; Cancer Research Program, Hospital del Mar Research Institute, Barcelona, Spain.<br /><searchLink fieldCode="AU" term="%22Harti+D%22">Harti D</searchLink>; Cancer Research Program, Hospital del Mar Research Institute, Barcelona, Spain.<br /><searchLink fieldCode="AU" term="%22Canton+E%22">Canton E</searchLink>; Cancer Research Program, Hospital del Mar Research Institute, Barcelona, Spain.; Josep Carreras Leukemia Research Institute, Badalona, Spain.<br /><searchLink fieldCode="AU" term="%22Andrades+E%22">Andrades E</searchLink>; Dermatology Department, Hospital del Mar, Barcelona, Spain.<br /><searchLink fieldCode="AU" term="%22Bertran+J%22">Bertran J</searchLink>; Faculty of Sciences, Technology and Engineering, Universitat de Vic - Universitat Central de Catalunya, Barcelona, Spain.<br /><searchLink fieldCode="AU" term="%22Martínez-Iniesta+M%22">Martínez-Iniesta M</searchLink>; Chemoresistance and Predictive Factors Group, Program Against Cancer Therapeutic Resistance (ProCURE), Catalan Institute of Oncology (ICO), Oncobell Program, Bellvitge Biomedical Research Institute (IDIBELL), L'Hospitalet del Llobregat, Barcelona, Spain.<br /><searchLink fieldCode="AU" term="%22Solé+L%22">Solé L</searchLink>; Cancer Research Program, Hospital del Mar Research Institute, Barcelona, Spain.; Centro de Investigación Biomédica en Red Cáncer (CIBERONC), Madrid, Spain.<br /><searchLink fieldCode="AU" term="%22García-Hernández+V%22">García-Hernández V</searchLink>; Cancer Research Program, Hospital del Mar Research Institute, Barcelona, Spain.<br /><searchLink fieldCode="AU" term="%22Montoto+Á%22">Montoto Á</searchLink>; Cancer Research Program, Hospital del Mar Research Institute, Barcelona, Spain.<br /><searchLink fieldCode="AU" term="%22Lobo-Jarne+T%22">Lobo-Jarne T</searchLink>; Cancer Research Program, Hospital del Mar Research Institute, Barcelona, Spain.<br /><searchLink fieldCode="AU" term="%22Alonso-Marañón+J%22">Alonso-Marañón J</searchLink>; Cancer Research Program, Hospital del Mar Research Institute, Barcelona, Spain.<br /><searchLink fieldCode="AU" term="%22Herrero-Molinero+P%22">Herrero-Molinero P</searchLink>; Cancer Research Program, Hospital del Mar Research Institute, Barcelona, Spain.<br /><searchLink fieldCode="AU" term="%22Larrubia-Loring+M%22">Larrubia-Loring M</searchLink>; Pathology Department, Hospital del Mar, Barcelona, Spain.<br /><searchLink fieldCode="AU" term="%22Tramuns+A%22">Tramuns A</searchLink>; Pathology Department, Hospital del Mar, Barcelona, Spain.<br /><searchLink fieldCode="AU" term="%22Wynne+K%22">Wynne K</searchLink>; Systems Biology Ireland, School of Medicine, University College Dublin, Belfield, Dublin, Ireland.; Conway Institute of Biomolecular and Biomedical Research, University College Dublin, Belfield, Ireland.<br /><searchLink fieldCode="AU" term="%22Bera+I%22">Bera I</searchLink>; Conway Institute of Biomolecular and Biomedical Research, University College Dublin, Belfield, Ireland.<br /><searchLink fieldCode="AU" term="%22Matallanas+D%22">Matallanas D</searchLink>; Conway Institute of Biomolecular and Biomedical Research, University College Dublin, Belfield, Ireland.<br /><searchLink fieldCode="AU" term="%22Villanueva+A%22">Villanueva A</searchLink>; Chemoresistance and Predictive Factors Group, Program Against Cancer Therapeutic Resistance (ProCURE), Catalan Institute of Oncology (ICO), Oncobell Program, Bellvitge Biomedical Research Institute (IDIBELL), L'Hospitalet del Llobregat, Barcelona, Spain.<br /><searchLink fieldCode="AU" term="%22Bigas+A%22">Bigas A</searchLink>; Cancer Research Program, Hospital del Mar Research Institute, Barcelona, Spain.; Josep Carreras Leukemia Research Institute, Badalona, Spain.; Centro de Investigación Biomédica en Red Cáncer (CIBERONC), Madrid, Spain.<br /><searchLink fieldCode="AU" term="%22Iglesias+M%22">Iglesias M</searchLink>; Centro de Investigación Biomédica en Red Cáncer (CIBERONC), Madrid, Spain.; Pathology Department, Hospital del Mar, Barcelona, Spain.; Universitat Pompeu Fabra (UPF), Barcelona, Spain.<br /><searchLink fieldCode="AU" term="%22Espinosa+L%22">Espinosa L</searchLink>; Cancer Research Program, Hospital del Mar Research Institute, Barcelona, Spain. lespinosa@researchmar.net.; Centro de Investigación Biomédica en Red Cáncer (CIBERONC), Madrid, Spain. lespinosa@researchmar.net.
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