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Bacterial ubiquitin ligase engineered for small molecule and protein target identification.

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Title: Bacterial ubiquitin ligase engineered for small molecule and protein target identification.
Authors: Ye JS; Department of Molecular Biology, University of Texas Southwestern Medical Center, Dallas, TX, 75390, USA., Majumdar A; Department of Molecular Biology, University of Texas Southwestern Medical Center, Dallas, TX, 75390, USA.; Howard Hughes Medical Institute, University of Texas Southwestern Medical Center, Dallas, TX, 75390, USA., Park BC; Department of Molecular Biology, University of Texas Southwestern Medical Center, Dallas, TX, 75390, USA., Black MH; Department of Molecular Biology, University of Texas Southwestern Medical Center, Dallas, TX, 75390, USA., Hsieh TS; Department of Molecular Biology, University of Texas Southwestern Medical Center, Dallas, TX, 75390, USA.; Howard Hughes Medical Institute, University of Texas Southwestern Medical Center, Dallas, TX, 75390, USA., Osinski A; Department of Molecular Biology, University of Texas Southwestern Medical Center, Dallas, TX, 75390, USA.; Howard Hughes Medical Institute, University of Texas Southwestern Medical Center, Dallas, TX, 75390, USA., Servage KA; Department of Molecular Biology, University of Texas Southwestern Medical Center, Dallas, TX, 75390, USA.; Howard Hughes Medical Institute, University of Texas Southwestern Medical Center, Dallas, TX, 75390, USA., Kulkarni K; Department of Internal Medicine, University of Texas Southwestern Medical Center, Dallas, TX, 75390, USA., Naidoo J; Department of Biochemistry, University of Texas Southwestern Medical Center, Dallas, TX, 75390, USA., Alto NM; Department of Microbiology, University of Texas Southwestern Medical Center, Dallas, TX, 75390, USA., Stratton MM; Department of Biochemistry and Molecular Biology, University of Massachusetts Amherst, Amherst, MA, 01003, USA., Alfandari D; Department of Veterinary and Animal Sciences, University of Massachusetts Amherst, Amherst, MA, 01003, USA., Ready JM; Department of Biochemistry, University of Texas Southwestern Medical Center, Dallas, TX, 75390, USA., Pawłowski K; Department of Molecular Biology, University of Texas Southwestern Medical Center, Dallas, TX, 75390, USA.; Howard Hughes Medical Institute, University of Texas Southwestern Medical Center, Dallas, TX, 75390, USA., Tomchick DR; Department of Biochemistry, University of Texas Southwestern Medical Center, Dallas, TX, 75390, USA.; Department of Biophysics, University of Texas Southwestern Medical Center, Dallas, TX, 75390, USA., Tagliabracci VS; Department of Molecular Biology, University of Texas Southwestern Medical Center, Dallas, TX, 75390, USA. vincent.tagliabracci@utsouthwestern.edu.; Howard Hughes Medical Institute, University of Texas Southwestern Medical Center, Dallas, TX, 75390, USA. vincent.tagliabracci@utsouthwestern.edu.; Harold C. Simmons Comprehensive Cancer Center, University of Texas Southwestern Medical Center, Dallas, TX, 75390, USA. vincent.tagliabracci@utsouthwestern.edu.; Hamon Center for Regenerative Science and Medicine, University of Texas Southwestern Medical Center, Dallas, TX, 75390, USA. vincent.tagliabracci@utsouthwestern.edu.
Source: The EMBO journal [EMBO J] 2026 Feb; Vol. 45 (3), pp. 1024-1050. Date of Electronic Publication: 2026 Jan 03.
Publication Type: Journal Article
Journal Info: Publisher: Nature Publishing Group Country of Publication: England NLM ID: 8208664 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1460-2075 (Electronic) Linking ISSN: 02614189 NLM ISO Abbreviation: EMBO J Subsets: MEDLINE
Database: MEDLINE Ultimate
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  Data: <searchLink fieldCode="AU" term="%22Ye+JS%22">Ye JS</searchLink>; Department of Molecular Biology, University of Texas Southwestern Medical Center, Dallas, TX, 75390, USA.<br /><searchLink fieldCode="AU" term="%22Majumdar+A%22">Majumdar A</searchLink>; Department of Molecular Biology, University of Texas Southwestern Medical Center, Dallas, TX, 75390, USA.; Howard Hughes Medical Institute, University of Texas Southwestern Medical Center, Dallas, TX, 75390, USA.<br /><searchLink fieldCode="AU" term="%22Park+BC%22">Park BC</searchLink>; Department of Molecular Biology, University of Texas Southwestern Medical Center, Dallas, TX, 75390, USA.<br /><searchLink fieldCode="AU" term="%22Black+MH%22">Black MH</searchLink>; Department of Molecular Biology, University of Texas Southwestern Medical Center, Dallas, TX, 75390, USA.<br /><searchLink fieldCode="AU" term="%22Hsieh+TS%22">Hsieh TS</searchLink>; Department of Molecular Biology, University of Texas Southwestern Medical Center, Dallas, TX, 75390, USA.; Howard Hughes Medical Institute, University of Texas Southwestern Medical Center, Dallas, TX, 75390, USA.<br /><searchLink fieldCode="AU" term="%22Osinski+A%22">Osinski A</searchLink>; Department of Molecular Biology, University of Texas Southwestern Medical Center, Dallas, TX, 75390, USA.; Howard Hughes Medical Institute, University of Texas Southwestern Medical Center, Dallas, TX, 75390, USA.<br /><searchLink fieldCode="AU" term="%22Servage+KA%22">Servage KA</searchLink>; Department of Molecular Biology, University of Texas Southwestern Medical Center, Dallas, TX, 75390, USA.; Howard Hughes Medical Institute, University of Texas Southwestern Medical Center, Dallas, TX, 75390, USA.<br /><searchLink fieldCode="AU" term="%22Kulkarni+K%22">Kulkarni K</searchLink>; Department of Internal Medicine, University of Texas Southwestern Medical Center, Dallas, TX, 75390, USA.<br /><searchLink fieldCode="AU" term="%22Naidoo+J%22">Naidoo J</searchLink>; Department of Biochemistry, University of Texas Southwestern Medical Center, Dallas, TX, 75390, USA.<br /><searchLink fieldCode="AU" term="%22Alto+NM%22">Alto NM</searchLink>; Department of Microbiology, University of Texas Southwestern Medical Center, Dallas, TX, 75390, USA.<br /><searchLink fieldCode="AU" term="%22Stratton+MM%22">Stratton MM</searchLink>; Department of Biochemistry and Molecular Biology, University of Massachusetts Amherst, Amherst, MA, 01003, USA.<br /><searchLink fieldCode="AU" term="%22Alfandari+D%22">Alfandari D</searchLink>; Department of Veterinary and Animal Sciences, University of Massachusetts Amherst, Amherst, MA, 01003, USA.<br /><searchLink fieldCode="AU" term="%22Ready+JM%22">Ready JM</searchLink>; Department of Biochemistry, University of Texas Southwestern Medical Center, Dallas, TX, 75390, USA.<br /><searchLink fieldCode="AU" term="%22Pawłowski+K%22">Pawłowski K</searchLink>; Department of Molecular Biology, University of Texas Southwestern Medical Center, Dallas, TX, 75390, USA.; Howard Hughes Medical Institute, University of Texas Southwestern Medical Center, Dallas, TX, 75390, USA.<br /><searchLink fieldCode="AU" term="%22Tomchick+DR%22">Tomchick DR</searchLink>; Department of Biochemistry, University of Texas Southwestern Medical Center, Dallas, TX, 75390, USA.; Department of Biophysics, University of Texas Southwestern Medical Center, Dallas, TX, 75390, USA.<br /><searchLink fieldCode="AU" term="%22Tagliabracci+VS%22">Tagliabracci VS</searchLink>; Department of Molecular Biology, University of Texas Southwestern Medical Center, Dallas, TX, 75390, USA. vincent.tagliabracci@utsouthwestern.edu.; Howard Hughes Medical Institute, University of Texas Southwestern Medical Center, Dallas, TX, 75390, USA. vincent.tagliabracci@utsouthwestern.edu.; Harold C. Simmons Comprehensive Cancer Center, University of Texas Southwestern Medical Center, Dallas, TX, 75390, USA. vincent.tagliabracci@utsouthwestern.edu.; Hamon Center for Regenerative Science and Medicine, University of Texas Southwestern Medical Center, Dallas, TX, 75390, USA. vincent.tagliabracci@utsouthwestern.edu.
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