Colon-targeted chitosan-gold nanoparticles loaded with Pueraria flavonoids for ulcerative colitis therapy via barrier repair and immune modulation.

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Title: Colon-targeted chitosan-gold nanoparticles loaded with Pueraria flavonoids for ulcerative colitis therapy via barrier repair and immune modulation.
Authors: Xu XY; State Key Laboratory of Respiratory Disease, National Clinical Research Center for Respiratory Disease, Guangzhou Institute of Respiratory Health, the First Affiliated Hospital of Guangzhou Medical University, Guangzhou, 510120, China., Yu H; School of Pharmacy, Jiangxi University of Chinese Medicine, Nanchang, China., Wang M; Institute of Traditional Chinese Medicine Health Industry, China Academy of Chinese Medical Sciences, Nanchang, 330115, China., Zhang FR; Beijing Key Laboratory of Traditional Chinese Medicine Basic Research on Prevention and Treatment for Major Diseases, Experimental Research Center, China Academy of Chinese Medical Sciences, Beijing, 100700, China., Liu M; Beijing Key Laboratory of Traditional Chinese Medicine Basic Research on Prevention and Treatment for Major Diseases, Experimental Research Center, China Academy of Chinese Medical Sciences, Beijing, 100700, China., Yang JC; Beijing Key Laboratory of Traditional Chinese Medicine Basic Research on Prevention and Treatment for Major Diseases, Experimental Research Center, China Academy of Chinese Medical Sciences, Beijing, 100700, China., Li XY; Beijing Key Laboratory of Traditional Chinese Medicine Basic Research on Prevention and Treatment for Major Diseases, Experimental Research Center, China Academy of Chinese Medical Sciences, Beijing, 100700, China. Electronic address: phd_xianyuli@foxmail.com., Yang HJ; Beijing Key Laboratory of Traditional Chinese Medicine Basic Research on Prevention and Treatment for Major Diseases, Experimental Research Center, China Academy of Chinese Medical Sciences, Beijing, 100700, China. Electronic address: hongjun0420@vip.sina.com., Meng Z; State Key Laboratory of Respiratory Disease, National Clinical Research Center for Respiratory Disease, Guangzhou Institute of Respiratory Health, the First Affiliated Hospital of Guangzhou Medical University, Guangzhou, 510120, China. Electronic address: mengzj@gzhmu.edu.cn.
Source: International journal of biological macromolecules [Int J Biol Macromol] 2026 Jan; Vol. 339 (Pt 2), pp. 150084. Date of Electronic Publication: 2026 Jan 02.
Publication Type: Journal Article
Journal Info: Publisher: Elsevier Country of Publication: Netherlands NLM ID: 7909578 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1879-0003 (Electronic) Linking ISSN: 01418130 NLM ISO Abbreviation: Int J Biol Macromol Subsets: MEDLINE
Database: MEDLINE Ultimate
Description
ISSN:1879-0003
DOI:10.1016/j.ijbiomac.2026.150084