Efficacy of sublingual and oral vitamin B12 versus intramuscular administration: insights from a systematic review and meta-analysis.

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Title: Efficacy of sublingual and oral vitamin B12 versus intramuscular administration: insights from a systematic review and meta-analysis.
Authors: Mazur M; BeSSA Department - Interdisciplinary Department of Well-being, Health and Environmental Sustainability, Sapienza University of Rome, Rieti, Italy.; Department of Interdisciplinary Dentistry, Pomeranian Medical University, Szczecin, Poland., Ndokaj A; Department of Oral and Maxillofacial Sciences, Sapienza University of Rome, Rome, Italy., Salerno C; Department of Biomedical, Surgical and Dental Sciences, University of Milan, Milan, Italy.; Department of Restorative, Preventive and Pediatric Dentistry, School of Dental Medicine, University of Bern, Bern, Switzerland., Vallone J; Department of Oral and Maxillofacial Sciences, Sapienza University of Rome, Rome, Italy., Ardan R; Department of Economic Sciences, Koszalin University of Technology, Koszalin, Poland., Bietolini S; Department of Humanities, Motor Sciences and Education, Niccolò Cusano University (UNICUSANO), Rome, Italy., Carrouel F; Health Systemic Process Laboratory (P2S), UR4129, University Claude Bernard Lyon 1, University of Lyon, Lyon, France., Wilk A; Department of Histology and Embryology, Pomeranian Medical University, Szczecin, Poland., Sarig R; Department of Oral Biology, The Goldschleger School of Dental Medicine, Gray Faculty of Medical and Health Sciences, Tel Aviv University, Tel Aviv, Israel., Ottolenghi L; Department of Oral and Maxillofacial Sciences, Sapienza University of Rome, Rome, Italy., Bourgeois D; Health Systemic Process Laboratory (P2S), UR4129, University Claude Bernard Lyon 1, University of Lyon, Lyon, France.
Source: Frontiers in pharmacology [Front Pharmacol] 2025 Dec 19; Vol. 16, pp. 1602976. Date of Electronic Publication: 2025 Dec 19 (Print Publication: 2025).
Publication Type: Journal Article; Systematic Review
Journal Info: Publisher: Frontiers Media] Country of Publication: Switzerland NLM ID: 101548923 Publication Model: eCollection Cited Medium: Print ISSN: 1663-9812 (Print) Linking ISSN: 16639812 NLM ISO Abbreviation: Front Pharmacol Subsets: PubMed not MEDLINE
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  Data: Efficacy of sublingual and oral vitamin B12 versus intramuscular administration: insights from a systematic review and meta-analysis.
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  Data: <searchLink fieldCode="AU" term="%22Mazur+M%22">Mazur M</searchLink>; BeSSA Department - Interdisciplinary Department of Well-being, Health and Environmental Sustainability, Sapienza University of Rome, Rieti, Italy.; Department of Interdisciplinary Dentistry, Pomeranian Medical University, Szczecin, Poland.<br /><searchLink fieldCode="AU" term="%22Ndokaj+A%22">Ndokaj A</searchLink>; Department of Oral and Maxillofacial Sciences, Sapienza University of Rome, Rome, Italy.<br /><searchLink fieldCode="AU" term="%22Salerno+C%22">Salerno C</searchLink>; Department of Biomedical, Surgical and Dental Sciences, University of Milan, Milan, Italy.; Department of Restorative, Preventive and Pediatric Dentistry, School of Dental Medicine, University of Bern, Bern, Switzerland.<br /><searchLink fieldCode="AU" term="%22Vallone+J%22">Vallone J</searchLink>; Department of Oral and Maxillofacial Sciences, Sapienza University of Rome, Rome, Italy.<br /><searchLink fieldCode="AU" term="%22Ardan+R%22">Ardan R</searchLink>; Department of Economic Sciences, Koszalin University of Technology, Koszalin, Poland.<br /><searchLink fieldCode="AU" term="%22Bietolini+S%22">Bietolini S</searchLink>; Department of Humanities, Motor Sciences and Education, Niccolò Cusano University (UNICUSANO), Rome, Italy.<br /><searchLink fieldCode="AU" term="%22Carrouel+F%22">Carrouel F</searchLink>; Health Systemic Process Laboratory (P2S), UR4129, University Claude Bernard Lyon 1, University of Lyon, Lyon, France.<br /><searchLink fieldCode="AU" term="%22Wilk+A%22">Wilk A</searchLink>; Department of Histology and Embryology, Pomeranian Medical University, Szczecin, Poland.<br /><searchLink fieldCode="AU" term="%22Sarig+R%22">Sarig R</searchLink>; Department of Oral Biology, The Goldschleger School of Dental Medicine, Gray Faculty of Medical and Health Sciences, Tel Aviv University, Tel Aviv, Israel.<br /><searchLink fieldCode="AU" term="%22Ottolenghi+L%22">Ottolenghi L</searchLink>; Department of Oral and Maxillofacial Sciences, Sapienza University of Rome, Rome, Italy.<br /><searchLink fieldCode="AU" term="%22Bourgeois+D%22">Bourgeois D</searchLink>; Health Systemic Process Laboratory (P2S), UR4129, University Claude Bernard Lyon 1, University of Lyon, Lyon, France.
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  Data: <searchLink fieldCode="JN" term="%22101548923%22">Frontiers in pharmacology</searchLink> [Front Pharmacol] 2025 Dec 19; Vol. 16, pp. 1602976. <i>Date of Electronic Publication: </i>2025 Dec 19 (<i>Print Publication: </i>2025).
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