Safety and therapeutic potential evaluation of Cefotaxime plus Polymyxin B against polymyxin-carbapenem resistant Klebsiella pneumoniae in a murine model.

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Title: Safety and therapeutic potential evaluation of Cefotaxime plus Polymyxin B against polymyxin-carbapenem resistant Klebsiella pneumoniae in a murine model.
Authors: Sturaro MC; Laboratory of Research in Health Science, Federal University of Grande Dourados, Dourados, Mato Grosso do Sul, Brazil., Damaceno NDS; Laboratory of Research in Health Science, Federal University of Grande Dourados, Dourados, Mato Grosso do Sul, Brazil., de Souza GHA; Laboratory of Research in Health Science, Federal University of Grande Dourados, Dourados, Mato Grosso do Sul, Brazil., Echeverria JES; Laboratory of Research in Health Science, Federal University of Grande Dourados, Dourados, Mato Grosso do Sul, Brazil., Cornelius EB; Laboratory of Research in Health Science, Federal University of Grande Dourados, Dourados, Mato Grosso do Sul, Brazil., Pires LP; Laboratory of Research in Health Science, Federal University of Grande Dourados, Dourados, Mato Grosso do Sul, Brazil., Silva PVDB; Laboratory of Research in Health Science, Federal University of Grande Dourados, Dourados, Mato Grosso do Sul, Brazil., Gomes BMC; University Center of Grande Dourados - UNIGRAN, Dourados, Mato Grosso do Sul, Brazil., Fraga TL; University Center of Grande Dourados - UNIGRAN, Dourados, Mato Grosso do Sul, Brazil., Silva ON; Evangelical University of Goiás, Anápolis, Goiás, Brazil., Rossato L; Laboratory of Research in Health Science, Federal University of Grande Dourados, Dourados, Mato Grosso do Sul, Brazil., Simionatto S; Laboratory of Research in Health Science, Federal University of Grande Dourados, Dourados, Mato Grosso do Sul, Brazil.
Source: PloS one [PLoS One] 2026 Jan 05; Vol. 21 (1), pp. e0339990. Date of Electronic Publication: 2026 Jan 05 (Print Publication: 2026).
Publication Type: Journal Article
Journal Info: Publisher: Public Library of Science Country of Publication: United States NLM ID: 101285081 Publication Model: eCollection Cited Medium: Internet ISSN: 1932-6203 (Electronic) Linking ISSN: 19326203 NLM ISO Abbreviation: PLoS One Subsets: MEDLINE
Database: MEDLINE Ultimate
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ISSN:1932-6203
DOI:10.1371/journal.pone.0339990