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Safety and therapeutic potential evaluation of Cefotaxime plus Polymyxin B against polymyxin-carbapenem resistant Klebsiella pneumoniae in a murine model.

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Title: Safety and therapeutic potential evaluation of Cefotaxime plus Polymyxin B against polymyxin-carbapenem resistant Klebsiella pneumoniae in a murine model.
Authors: Sturaro MC; Laboratory of Research in Health Science, Federal University of Grande Dourados, Dourados, Mato Grosso do Sul, Brazil., Damaceno NDS; Laboratory of Research in Health Science, Federal University of Grande Dourados, Dourados, Mato Grosso do Sul, Brazil., de Souza GHA; Laboratory of Research in Health Science, Federal University of Grande Dourados, Dourados, Mato Grosso do Sul, Brazil., Echeverria JES; Laboratory of Research in Health Science, Federal University of Grande Dourados, Dourados, Mato Grosso do Sul, Brazil., Cornelius EB; Laboratory of Research in Health Science, Federal University of Grande Dourados, Dourados, Mato Grosso do Sul, Brazil., Pires LP; Laboratory of Research in Health Science, Federal University of Grande Dourados, Dourados, Mato Grosso do Sul, Brazil., Silva PVDB; Laboratory of Research in Health Science, Federal University of Grande Dourados, Dourados, Mato Grosso do Sul, Brazil., Gomes BMC; University Center of Grande Dourados - UNIGRAN, Dourados, Mato Grosso do Sul, Brazil., Fraga TL; University Center of Grande Dourados - UNIGRAN, Dourados, Mato Grosso do Sul, Brazil., Silva ON; Evangelical University of Goiás, Anápolis, Goiás, Brazil., Rossato L; Laboratory of Research in Health Science, Federal University of Grande Dourados, Dourados, Mato Grosso do Sul, Brazil., Simionatto S; Laboratory of Research in Health Science, Federal University of Grande Dourados, Dourados, Mato Grosso do Sul, Brazil.
Source: PloS one [PLoS One] 2026 Jan 05; Vol. 21 (1), pp. e0339990. Date of Electronic Publication: 2026 Jan 05 (Print Publication: 2026).
Publication Type: Journal Article
Journal Info: Publisher: Public Library of Science Country of Publication: United States NLM ID: 101285081 Publication Model: eCollection Cited Medium: Internet ISSN: 1932-6203 (Electronic) Linking ISSN: 19326203 NLM ISO Abbreviation: PLoS One Subsets: MEDLINE
Database: MEDLINE Ultimate
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  Data: Safety and therapeutic potential evaluation of Cefotaxime plus Polymyxin B against polymyxin-carbapenem resistant Klebsiella pneumoniae in a murine model.
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  Data: <searchLink fieldCode="AU" term="%22Sturaro+MC%22">Sturaro MC</searchLink>; Laboratory of Research in Health Science, Federal University of Grande Dourados, Dourados, Mato Grosso do Sul, Brazil.<br /><searchLink fieldCode="AU" term="%22Damaceno+NDS%22">Damaceno NDS</searchLink>; Laboratory of Research in Health Science, Federal University of Grande Dourados, Dourados, Mato Grosso do Sul, Brazil.<br /><searchLink fieldCode="AU" term="%22de+Souza+GHA%22">de Souza GHA</searchLink>; Laboratory of Research in Health Science, Federal University of Grande Dourados, Dourados, Mato Grosso do Sul, Brazil.<br /><searchLink fieldCode="AU" term="%22Echeverria+JES%22">Echeverria JES</searchLink>; Laboratory of Research in Health Science, Federal University of Grande Dourados, Dourados, Mato Grosso do Sul, Brazil.<br /><searchLink fieldCode="AU" term="%22Cornelius+EB%22">Cornelius EB</searchLink>; Laboratory of Research in Health Science, Federal University of Grande Dourados, Dourados, Mato Grosso do Sul, Brazil.<br /><searchLink fieldCode="AU" term="%22Pires+LP%22">Pires LP</searchLink>; Laboratory of Research in Health Science, Federal University of Grande Dourados, Dourados, Mato Grosso do Sul, Brazil.<br /><searchLink fieldCode="AU" term="%22Silva+PVDB%22">Silva PVDB</searchLink>; Laboratory of Research in Health Science, Federal University of Grande Dourados, Dourados, Mato Grosso do Sul, Brazil.<br /><searchLink fieldCode="AU" term="%22Gomes+BMC%22">Gomes BMC</searchLink>; University Center of Grande Dourados - UNIGRAN, Dourados, Mato Grosso do Sul, Brazil.<br /><searchLink fieldCode="AU" term="%22Fraga+TL%22">Fraga TL</searchLink>; University Center of Grande Dourados - UNIGRAN, Dourados, Mato Grosso do Sul, Brazil.<br /><searchLink fieldCode="AU" term="%22Silva+ON%22">Silva ON</searchLink>; Evangelical University of Goiás, Anápolis, Goiás, Brazil.<br /><searchLink fieldCode="AU" term="%22Rossato+L%22">Rossato L</searchLink>; Laboratory of Research in Health Science, Federal University of Grande Dourados, Dourados, Mato Grosso do Sul, Brazil.<br /><searchLink fieldCode="AU" term="%22Simionatto+S%22">Simionatto S</searchLink>; Laboratory of Research in Health Science, Federal University of Grande Dourados, Dourados, Mato Grosso do Sul, Brazil.
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  Data: <searchLink fieldCode="JN" term="%22101285081%22">PloS one</searchLink> [PLoS One] 2026 Jan 05; Vol. 21 (1), pp. e0339990. <i>Date of Electronic Publication: </i>2026 Jan 05 (<i>Print Publication: </i>2026).
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