Dual Bcl-2/Bcl-xl inhibition via AZD0466 combines with immune checkpoint blockade to enhance anti-tumour activity.
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| Title: | Dual Bcl-2/Bcl-xl inhibition via AZD0466 combines with immune checkpoint blockade to enhance anti-tumour activity. |
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| Authors: | Newman DM; The Sir Peter MacCallum Department of Oncology, University of Melbourne, Parkville, VIC, Australia.; Gene Regulation Laboratory, Peter MacCallum Cancer Centre, Grattan Street, 3000, Melbourne, Australia., Andersen CL; Oncology R&D, AstraZeneca, Waltham, MA, USA., Cluse LA; The Sir Peter MacCallum Department of Oncology, University of Melbourne, Parkville, VIC, Australia.; Gene Regulation Laboratory, Peter MacCallum Cancer Centre, Grattan Street, 3000, Melbourne, Australia., Newbold A; The Sir Peter MacCallum Department of Oncology, University of Melbourne, Parkville, VIC, Australia.; Gene Regulation Laboratory, Peter MacCallum Cancer Centre, Grattan Street, 3000, Melbourne, Australia., Fraser P; The Sir Peter MacCallum Department of Oncology, University of Melbourne, Parkville, VIC, Australia.; Gene Regulation Laboratory, Peter MacCallum Cancer Centre, Grattan Street, 3000, Melbourne, Australia., Legg BWC; The Sir Peter MacCallum Department of Oncology, University of Melbourne, Parkville, VIC, Australia.; Gene Regulation Laboratory, Peter MacCallum Cancer Centre, Grattan Street, 3000, Melbourne, Australia., Xu LK; Oncology R&D, AstraZeneca, Waltham, MA, USA., Mele DA; Oncology R&D, AstraZeneca, Waltham, MA, USA. deanna.mele@astrazeneca.com., Johnstone RW; The Sir Peter MacCallum Department of Oncology, University of Melbourne, Parkville, VIC, Australia. ricky.johnstone@petermac.org.; Gene Regulation Laboratory, Peter MacCallum Cancer Centre, Grattan Street, 3000, Melbourne, Australia. ricky.johnstone@petermac.org. |
| Source: | Cell death & disease [Cell Death Dis] 2026 Jan 06; Vol. 17 (1), pp. 177. Date of Electronic Publication: 2026 Jan 06. |
| Publication Type: | Journal Article |
| Journal Info: | Publisher: Nature Pub. Group Country of Publication: England NLM ID: 101524092 Publication Model: Electronic Cited Medium: Internet ISSN: 2041-4889 (Electronic) NLM ISO Abbreviation: Cell Death Dis Subsets: MEDLINE |
| Database: | MEDLINE Ultimate |
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| ISSN: | 2041-4889 |
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| DOI: | 10.1038/s41419-025-08354-w |
