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Gut-Bone Axis Mediates Exercise Modality-Dependent Suppression of Inflammatory Osteoclastogenesis in Ovariectomy-Induced Bone Loss.

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Title: Gut-Bone Axis Mediates Exercise Modality-Dependent Suppression of Inflammatory Osteoclastogenesis in Ovariectomy-Induced Bone Loss.
Authors: Gao Y; Department of Orthopaedics, Affiliated ZhongDa Hospital, Medical School of Southeast University, Nanjing, Jiangsu Province, China, seu.edu.cn.; Orthopaedic Trauma Institute (OTI), Southeast University, Nanjing, Jiangsu Province, China, seu.edu.bd.; Trauma Center, Affiliated ZhongDa Hospital, Medical School of Southeast University, Nanjing, Jiangsu Province, China, seu.edu.cn.; Multidisciplinary Team (MDT) for Geriatric Hip Fracture Management, Affiliated ZhongDa Hospital, Medical School of Southeast University, Nanjing, Jiangsu Province, China, seu.edu.cn.; Medical School of Southeast University, Nanjing, Jiangsu Province, China, seu.edu.cn., Wang H; Department of Orthopaedics, Affiliated ZhongDa Hospital, Medical School of Southeast University, Nanjing, Jiangsu Province, China, seu.edu.cn.; Orthopaedic Trauma Institute (OTI), Southeast University, Nanjing, Jiangsu Province, China, seu.edu.bd.; Trauma Center, Affiliated ZhongDa Hospital, Medical School of Southeast University, Nanjing, Jiangsu Province, China, seu.edu.cn.; Multidisciplinary Team (MDT) for Geriatric Hip Fracture Management, Affiliated ZhongDa Hospital, Medical School of Southeast University, Nanjing, Jiangsu Province, China, seu.edu.cn.; Medical School of Southeast University, Nanjing, Jiangsu Province, China, seu.edu.cn., Shi L; Department of Orthopaedics, Affiliated ZhongDa Hospital, Medical School of Southeast University, Nanjing, Jiangsu Province, China, seu.edu.cn.; Orthopaedic Trauma Institute (OTI), Southeast University, Nanjing, Jiangsu Province, China, seu.edu.bd.; Trauma Center, Affiliated ZhongDa Hospital, Medical School of Southeast University, Nanjing, Jiangsu Province, China, seu.edu.cn.; Multidisciplinary Team (MDT) for Geriatric Hip Fracture Management, Affiliated ZhongDa Hospital, Medical School of Southeast University, Nanjing, Jiangsu Province, China, seu.edu.cn.; Medical School of Southeast University, Nanjing, Jiangsu Province, China, seu.edu.cn., Cao M; Department of Orthopaedics, Affiliated ZhongDa Hospital, Medical School of Southeast University, Nanjing, Jiangsu Province, China, seu.edu.cn.; Orthopaedic Trauma Institute (OTI), Southeast University, Nanjing, Jiangsu Province, China, seu.edu.bd.; Trauma Center, Affiliated ZhongDa Hospital, Medical School of Southeast University, Nanjing, Jiangsu Province, China, seu.edu.cn.; Multidisciplinary Team (MDT) for Geriatric Hip Fracture Management, Affiliated ZhongDa Hospital, Medical School of Southeast University, Nanjing, Jiangsu Province, China, seu.edu.cn.; Medical School of Southeast University, Nanjing, Jiangsu Province, China, seu.edu.cn., Liu X; Department of Orthopaedics, Affiliated ZhongDa Hospital, Medical School of Southeast University, Nanjing, Jiangsu Province, China, seu.edu.cn.; Orthopaedic Trauma Institute (OTI), Southeast University, Nanjing, Jiangsu Province, China, seu.edu.bd.; Trauma Center, Affiliated ZhongDa Hospital, Medical School of Southeast University, Nanjing, Jiangsu Province, China, seu.edu.cn.; Multidisciplinary Team (MDT) for Geriatric Hip Fracture Management, Affiliated ZhongDa Hospital, Medical School of Southeast University, Nanjing, Jiangsu Province, China, seu.edu.cn.; Medical School of Southeast University, Nanjing, Jiangsu Province, China, seu.edu.cn., Zhang Y; Department of Orthopaedics, Xinhua Hospital, Medical School of Shanghai JiaoTong University, Shanghai, China., Chen X; Department of Orthopaedics, Affiliated ZhongDa Hospital, Medical School of Southeast University, Nanjing, Jiangsu Province, China, seu.edu.cn.; Orthopaedic Trauma Institute (OTI), Southeast University, Nanjing, Jiangsu Province, China, seu.edu.bd.; Trauma Center, Affiliated ZhongDa Hospital, Medical School of Southeast University, Nanjing, Jiangsu Province, China, seu.edu.cn.; Multidisciplinary Team (MDT) for Geriatric Hip Fracture Management, Affiliated ZhongDa Hospital, Medical School of Southeast University, Nanjing, Jiangsu Province, China, seu.edu.cn.; Medical School of Southeast University, Nanjing, Jiangsu Province, China, seu.edu.cn., Rong Y; Medical School of Southeast University, Nanjing, Jiangsu Province, China, seu.edu.cn., Han B; Medical School of Southeast University, Nanjing, Jiangsu Province, China, seu.edu.cn., Lu P; Department of Orthopaedics, Affiliated ZhongDa Hospital, Medical School of Southeast University, Nanjing, Jiangsu Province, China, seu.edu.cn.; Orthopaedic Trauma Institute (OTI), Southeast University, Nanjing, Jiangsu Province, China, seu.edu.bd.; Trauma Center, Affiliated ZhongDa Hospital, Medical School of Southeast University, Nanjing, Jiangsu Province, China, seu.edu.cn.; Multidisciplinary Team (MDT) for Geriatric Hip Fracture Management, Affiliated ZhongDa Hospital, Medical School of Southeast University, Nanjing, Jiangsu Province, China, seu.edu.cn.; Medical School of Southeast University, Nanjing, Jiangsu Province, China, seu.edu.cn., Dai G; Department of Orthopaedics, Affiliated ZhongDa Hospital, Medical School of Southeast University, Nanjing, Jiangsu Province, China, seu.edu.cn.; Orthopaedic Trauma Institute (OTI), Southeast University, Nanjing, Jiangsu Province, China, seu.edu.bd.; Trauma Center, Affiliated ZhongDa Hospital, Medical School of Southeast University, Nanjing, Jiangsu Province, China, seu.edu.cn.; Multidisciplinary Team (MDT) for Geriatric Hip Fracture Management, Affiliated ZhongDa Hospital, Medical School of Southeast University, Nanjing, Jiangsu Province, China, seu.edu.cn.; Medical School of Southeast University, Nanjing, Jiangsu Province, China, seu.edu.cn., Fan W; Department of Orthopaedics, Affiliated ZhongDa Hospital, Medical School of Southeast University, Nanjing, Jiangsu Province, China, seu.edu.cn.; Orthopaedic Trauma Institute (OTI), Southeast University, Nanjing, Jiangsu Province, China, seu.edu.bd.; Trauma Center, Affiliated ZhongDa Hospital, Medical School of Southeast University, Nanjing, Jiangsu Province, China, seu.edu.cn.; Multidisciplinary Team (MDT) for Geriatric Hip Fracture Management, Affiliated ZhongDa Hospital, Medical School of Southeast University, Nanjing, Jiangsu Province, China, seu.edu.cn.; Medical School of Southeast University, Nanjing, Jiangsu Province, China, seu.edu.cn., Rui Y; Department of Orthopaedics, Affiliated ZhongDa Hospital, Medical School of Southeast University, Nanjing, Jiangsu Province, China, seu.edu.cn.; Orthopaedic Trauma Institute (OTI), Southeast University, Nanjing, Jiangsu Province, China, seu.edu.bd.; Trauma Center, Affiliated ZhongDa Hospital, Medical School of Southeast University, Nanjing, Jiangsu Province, China, seu.edu.cn.; Multidisciplinary Team (MDT) for Geriatric Hip Fracture Management, Affiliated ZhongDa Hospital, Medical School of Southeast University, Nanjing, Jiangsu Province, China, seu.edu.cn.; Medical School of Southeast University, Nanjing, Jiangsu Province, China, seu.edu.cn., Li Y; Multidisciplinary Team (MDT) for Geriatric Hip Fracture Management, Affiliated ZhongDa Hospital, Medical School of Southeast University, Nanjing, Jiangsu Province, China, seu.edu.cn.; Department of Geriatrics, Affiliated ZhongDa Hospital, Medical School of Southeast University, Nanjing, Jiangsu Province, China, seu.edu.cn.
Source: Mediators of inflammation [Mediators Inflamm] 2025 Dec 12; Vol. 2025, pp. 5715332. Date of Electronic Publication: 2025 Dec 12 (Print Publication: 2025).
Publication Type: Comparative Study; Journal Article
Journal Info: Publisher: Wiley Country of Publication: United States NLM ID: 9209001 Publication Model: eCollection Cited Medium: Internet ISSN: 1466-1861 (Electronic) Linking ISSN: 09629351 NLM ISO Abbreviation: Mediators Inflamm Subsets: MEDLINE
Database: MEDLINE Ultimate
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ISSN:1466-1861
DOI:10.1155/mi/5715332