Efficacy and safety of orforglipron in type 2 diabetes mellitus and obesity: a GRADE-assessed meta-analysis and trial sequential analysis with subgroup evaluations by diabetic status, obesity status, and dose regimens.
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| Title: | Efficacy and safety of orforglipron in type 2 diabetes mellitus and obesity: a GRADE-assessed meta-analysis and trial sequential analysis with subgroup evaluations by diabetic status, obesity status, and dose regimens. |
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| Authors: | Jamal A; Khyber Medical College, Peshawar, Pakistan., Khan S; Khyber Medical College, Peshawar, Pakistan. dr.sulemandawar@gmail.com., Qadri M; Jinnah Sindh Medical University, Karachi, Pakistan., Shah A; Khyber Medical College, Peshawar, Pakistan., Iftikhar H; Khyber Medical College, Peshawar, Pakistan., Fatima E; Allama Iqbal Medical College, Lahore, Pakistan., Ahmad M; Bacha Khan Medical College, Mardan, Pakistan., Sikandar M; Khyber Medical College, Peshawar, Pakistan., Jawed I; Dow Medical College, Karachi, Pakistan., Muneeb M; Khyber Medical College, Peshawar, Pakistan., Mohmand MS; Khyber Medical College, Peshawar, Pakistan., Bacha Z; Khyber Medical College, Peshawar, Pakistan., Khan BW; Khyber Medical College, Peshawar, Pakistan., Jamal T; National Institute of Health, Islamabad, Pakistan., Khalid AA; Peshawar Medical College, Peshawar, Pakistan., Khan MI; Medical University of Sofia, Sofia, Bulgaria., Zulkaif M; Khyber Medical College, Peshawar, Pakistan. |
| Source: | Acta diabetologica [Acta Diabetol] 2026 Apr; Vol. 63 (4), pp. 711-725. Date of Electronic Publication: 2026 Jan 07. |
| Publication Type: | Journal Article; Meta-Analysis; Review |
| Journal Info: | Publisher: Springer Verlag Country of Publication: Germany NLM ID: 9200299 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1432-5233 (Electronic) Linking ISSN: 09405429 NLM ISO Abbreviation: Acta Diabetol Subsets: MEDLINE |
| Database: | MEDLINE Ultimate |
| ISSN: | 1432-5233 |
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| DOI: | 10.1007/s00592-025-02635-8 |
