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Efficacy and safety of orforglipron in type 2 diabetes mellitus and obesity: a GRADE-assessed meta-analysis and trial sequential analysis with subgroup evaluations by diabetic status, obesity status, and dose regimens.

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Title: Efficacy and safety of orforglipron in type 2 diabetes mellitus and obesity: a GRADE-assessed meta-analysis and trial sequential analysis with subgroup evaluations by diabetic status, obesity status, and dose regimens.
Authors: Jamal A; Khyber Medical College, Peshawar, Pakistan., Khan S; Khyber Medical College, Peshawar, Pakistan. dr.sulemandawar@gmail.com., Qadri M; Jinnah Sindh Medical University, Karachi, Pakistan., Shah A; Khyber Medical College, Peshawar, Pakistan., Iftikhar H; Khyber Medical College, Peshawar, Pakistan., Fatima E; Allama Iqbal Medical College, Lahore, Pakistan., Ahmad M; Bacha Khan Medical College, Mardan, Pakistan., Sikandar M; Khyber Medical College, Peshawar, Pakistan., Jawed I; Dow Medical College, Karachi, Pakistan., Muneeb M; Khyber Medical College, Peshawar, Pakistan., Mohmand MS; Khyber Medical College, Peshawar, Pakistan., Bacha Z; Khyber Medical College, Peshawar, Pakistan., Khan BW; Khyber Medical College, Peshawar, Pakistan., Jamal T; National Institute of Health, Islamabad, Pakistan., Khalid AA; Peshawar Medical College, Peshawar, Pakistan., Khan MI; Medical University of Sofia, Sofia, Bulgaria., Zulkaif M; Khyber Medical College, Peshawar, Pakistan.
Source: Acta diabetologica [Acta Diabetol] 2026 Apr; Vol. 63 (4), pp. 711-725. Date of Electronic Publication: 2026 Jan 07.
Publication Type: Journal Article; Meta-Analysis; Review
Journal Info: Publisher: Springer Verlag Country of Publication: Germany NLM ID: 9200299 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1432-5233 (Electronic) Linking ISSN: 09405429 NLM ISO Abbreviation: Acta Diabetol Subsets: MEDLINE
Database: MEDLINE Ultimate
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  Data: Efficacy and safety of orforglipron in type 2 diabetes mellitus and obesity: a GRADE-assessed meta-analysis and trial sequential analysis with subgroup evaluations by diabetic status, obesity status, and dose regimens.
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  Data: <searchLink fieldCode="AU" term="%22Jamal+A%22">Jamal A</searchLink>; Khyber Medical College, Peshawar, Pakistan.<br /><searchLink fieldCode="AU" term="%22Khan+S%22">Khan S</searchLink>; Khyber Medical College, Peshawar, Pakistan. dr.sulemandawar@gmail.com.<br /><searchLink fieldCode="AU" term="%22Qadri+M%22">Qadri M</searchLink>; Jinnah Sindh Medical University, Karachi, Pakistan.<br /><searchLink fieldCode="AU" term="%22Shah+A%22">Shah A</searchLink>; Khyber Medical College, Peshawar, Pakistan.<br /><searchLink fieldCode="AU" term="%22Iftikhar+H%22">Iftikhar H</searchLink>; Khyber Medical College, Peshawar, Pakistan.<br /><searchLink fieldCode="AU" term="%22Fatima+E%22">Fatima E</searchLink>; Allama Iqbal Medical College, Lahore, Pakistan.<br /><searchLink fieldCode="AU" term="%22Ahmad+M%22">Ahmad M</searchLink>; Bacha Khan Medical College, Mardan, Pakistan.<br /><searchLink fieldCode="AU" term="%22Sikandar+M%22">Sikandar M</searchLink>; Khyber Medical College, Peshawar, Pakistan.<br /><searchLink fieldCode="AU" term="%22Jawed+I%22">Jawed I</searchLink>; Dow Medical College, Karachi, Pakistan.<br /><searchLink fieldCode="AU" term="%22Muneeb+M%22">Muneeb M</searchLink>; Khyber Medical College, Peshawar, Pakistan.<br /><searchLink fieldCode="AU" term="%22Mohmand+MS%22">Mohmand MS</searchLink>; Khyber Medical College, Peshawar, Pakistan.<br /><searchLink fieldCode="AU" term="%22Bacha+Z%22">Bacha Z</searchLink>; Khyber Medical College, Peshawar, Pakistan.<br /><searchLink fieldCode="AU" term="%22Khan+BW%22">Khan BW</searchLink>; Khyber Medical College, Peshawar, Pakistan.<br /><searchLink fieldCode="AU" term="%22Jamal+T%22">Jamal T</searchLink>; National Institute of Health, Islamabad, Pakistan.<br /><searchLink fieldCode="AU" term="%22Khalid+AA%22">Khalid AA</searchLink>; Peshawar Medical College, Peshawar, Pakistan.<br /><searchLink fieldCode="AU" term="%22Khan+MI%22">Khan MI</searchLink>; Medical University of Sofia, Sofia, Bulgaria.<br /><searchLink fieldCode="AU" term="%22Zulkaif+M%22">Zulkaif M</searchLink>; Khyber Medical College, Peshawar, Pakistan.
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  Data: <searchLink fieldCode="JN" term="%229200299%22">Acta diabetologica</searchLink> [Acta Diabetol] 2026 Apr; Vol. 63 (4), pp. 711-725. <i>Date of Electronic Publication: </i>2026 Jan 07.
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  Data: <i>Publisher: </i><searchLink fieldCode="PB" term="%22Springer+Verlag%22">Springer Verlag </searchLink><i>Country of Publication: </i>Germany <i>NLM ID: </i>9200299 <i>Publication Model: </i>Print-Electronic <i>Cited Medium: </i>Internet <i>ISSN: </i>1432-5233 (Electronic) <i>Linking ISSN: </i><searchLink fieldCode="IS" term="%2209405429%22">09405429 </searchLink><i>NLM ISO Abbreviation: </i>Acta Diabetol <i>Subsets: </i>MEDLINE
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