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Drug and single-cell gene expression integration identifies sensitive and resistant glioblastoma cell populations.

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Title: Drug and single-cell gene expression integration identifies sensitive and resistant glioblastoma cell populations.
Authors: Suter RK; Department of Oncology, Lombardi Comprehensive Cancer Center, Georgetown University, Washington, DC, USA. RKS82@Georgetown.edu., Jermakowicz AM; Department of Oncology, Lombardi Comprehensive Cancer Center, Georgetown University, Washington, DC, USA., Veeramachaneni R; Department of Oncology, Lombardi Comprehensive Cancer Center, Georgetown University, Washington, DC, USA., D'Antuono M; Department of Oncology, Lombardi Comprehensive Cancer Center, Georgetown University, Washington, DC, USA., Zhang L; Department of Oncology, Lombardi Comprehensive Cancer Center, Georgetown University, Washington, DC, USA., Chowdary R; Department of Oncology, Lombardi Comprehensive Cancer Center, Georgetown University, Washington, DC, USA., Kaeppeli S; Department of Oncology, Lombardi Comprehensive Cancer Center, Georgetown University, Washington, DC, USA., Sharp M; Department of Oncology, Lombardi Comprehensive Cancer Center, Georgetown University, Washington, DC, USA., Palwai P; Department of Oncology, Lombardi Comprehensive Cancer Center, Georgetown University, Washington, DC, USA., Stathias V; Department of Molecular and Cellular Pharmacology, Institute for Data Science & Computing, University of Miami Miller School of Medicine, Miami, FL, USA.; Sylvester Comprehensive Cancer Center, University of Miami Miller School of Medicine, Miami, FL, USA., Baker G; Department of Oncology, Lombardi Comprehensive Cancer Center, Georgetown University, Washington, DC, USA., Ruiz L; Department of Oncology, Lombardi Comprehensive Cancer Center, Georgetown University, Washington, DC, USA., Walters W; Department of Neurological Surgery, University of Miami Miller School of Medicine, Miami, FL, USA., Cepero M; Department of Neurology, University of Miami Miller School of Medicine, Miami, FL, USA., Burgenske D; Department of Radiation Oncology, Mayo Clinic, Rochester, MN, USA., Reilly EB; AbbVie, Oncology Discovery, North Chicago, IL, USA., Oleksijew A; AbbVie, Oncology Discovery, North Chicago, IL, USA., Anderson MG; AbbVie, Oncology Discovery, North Chicago, IL, USA., Williams SL; Sylvester Comprehensive Cancer Center, University of Miami Miller School of Medicine, Miami, FL, USA.; Department of Neurology, University of Miami Miller School of Medicine, Miami, FL, USA., Ivan ME; Sylvester Comprehensive Cancer Center, University of Miami Miller School of Medicine, Miami, FL, USA.; Department of Neurological Surgery, University of Miami Miller School of Medicine, Miami, FL, USA., Komotar RJ; Sylvester Comprehensive Cancer Center, University of Miami Miller School of Medicine, Miami, FL, USA.; Department of Neurological Surgery, University of Miami Miller School of Medicine, Miami, FL, USA., De La Fuente MI; Sylvester Comprehensive Cancer Center, University of Miami Miller School of Medicine, Miami, FL, USA.; Department of Neurology, University of Miami Miller School of Medicine, Miami, FL, USA., Stein G; Curtana Pharmaceuticals, Inc., Austin, TX, USA., Wojcinski A; Pacific Neuroscience Institute and Saint John's Cancer Institute, Providence Health System, Santa Monica, CA, USA., Kesari S; Pacific Neuroscience Institute and Saint John's Cancer Institute, Providence Health System, Santa Monica, CA, USA.; Asthra Health and Lundquist Institute, Santa Monica, CA, USA., Sarkaria JN; Department of Radiation Oncology, Mayo Clinic, Rochester, MN, USA., Schürer SC; Department of Molecular and Cellular Pharmacology, Institute for Data Science & Computing, University of Miami Miller School of Medicine, Miami, FL, USA.; Sylvester Comprehensive Cancer Center, University of Miami Miller School of Medicine, Miami, FL, USA., Ayad NG; Department of Oncology, Lombardi Comprehensive Cancer Center, Georgetown University, Washington, DC, USA. NA853@Georgetown.edu.
Source: Nature communications [Nat Commun] 2026 Jan 07; Vol. 17 (1), pp. 99. Date of Electronic Publication: 2026 Jan 07.
Publication Type: Journal Article
Journal Info: Publisher: Nature Pub. Group Country of Publication: England NLM ID: 101528555 Publication Model: Electronic Cited Medium: Internet ISSN: 2041-1723 (Electronic) Linking ISSN: 20411723 NLM ISO Abbreviation: Nat Commun Subsets: MEDLINE
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  Data: Drug and single-cell gene expression integration identifies sensitive and resistant glioblastoma cell populations.
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  Data: <searchLink fieldCode="AU" term="%22Suter+RK%22">Suter RK</searchLink>; Department of Oncology, Lombardi Comprehensive Cancer Center, Georgetown University, Washington, DC, USA. RKS82@Georgetown.edu.<br /><searchLink fieldCode="AU" term="%22Jermakowicz+AM%22">Jermakowicz AM</searchLink>; Department of Oncology, Lombardi Comprehensive Cancer Center, Georgetown University, Washington, DC, USA.<br /><searchLink fieldCode="AU" term="%22Veeramachaneni+R%22">Veeramachaneni R</searchLink>; Department of Oncology, Lombardi Comprehensive Cancer Center, Georgetown University, Washington, DC, USA.<br /><searchLink fieldCode="AU" term="%22D'Antuono+M%22">D'Antuono M</searchLink>; Department of Oncology, Lombardi Comprehensive Cancer Center, Georgetown University, Washington, DC, USA.<br /><searchLink fieldCode="AU" term="%22Zhang+L%22">Zhang L</searchLink>; Department of Oncology, Lombardi Comprehensive Cancer Center, Georgetown University, Washington, DC, USA.<br /><searchLink fieldCode="AU" term="%22Chowdary+R%22">Chowdary R</searchLink>; Department of Oncology, Lombardi Comprehensive Cancer Center, Georgetown University, Washington, DC, USA.<br /><searchLink fieldCode="AU" term="%22Kaeppeli+S%22">Kaeppeli S</searchLink>; Department of Oncology, Lombardi Comprehensive Cancer Center, Georgetown University, Washington, DC, USA.<br /><searchLink fieldCode="AU" term="%22Sharp+M%22">Sharp M</searchLink>; Department of Oncology, Lombardi Comprehensive Cancer Center, Georgetown University, Washington, DC, USA.<br /><searchLink fieldCode="AU" term="%22Palwai+P%22">Palwai P</searchLink>; Department of Oncology, Lombardi Comprehensive Cancer Center, Georgetown University, Washington, DC, USA.<br /><searchLink fieldCode="AU" term="%22Stathias+V%22">Stathias V</searchLink>; Department of Molecular and Cellular Pharmacology, Institute for Data Science & Computing, University of Miami Miller School of Medicine, Miami, FL, USA.; Sylvester Comprehensive Cancer Center, University of Miami Miller School of Medicine, Miami, FL, USA.<br /><searchLink fieldCode="AU" term="%22Baker+G%22">Baker G</searchLink>; Department of Oncology, Lombardi Comprehensive Cancer Center, Georgetown University, Washington, DC, USA.<br /><searchLink fieldCode="AU" term="%22Ruiz+L%22">Ruiz L</searchLink>; Department of Oncology, Lombardi Comprehensive Cancer Center, Georgetown University, Washington, DC, USA.<br /><searchLink fieldCode="AU" term="%22Walters+W%22">Walters W</searchLink>; Department of Neurological Surgery, University of Miami Miller School of Medicine, Miami, FL, USA.<br /><searchLink fieldCode="AU" term="%22Cepero+M%22">Cepero M</searchLink>; Department of Neurology, University of Miami Miller School of Medicine, Miami, FL, USA.<br /><searchLink fieldCode="AU" term="%22Burgenske+D%22">Burgenske D</searchLink>; Department of Radiation Oncology, Mayo Clinic, Rochester, MN, USA.<br /><searchLink fieldCode="AU" term="%22Reilly+EB%22">Reilly EB</searchLink>; AbbVie, Oncology Discovery, North Chicago, IL, USA.<br /><searchLink fieldCode="AU" term="%22Oleksijew+A%22">Oleksijew A</searchLink>; AbbVie, Oncology Discovery, North Chicago, IL, USA.<br /><searchLink fieldCode="AU" term="%22Anderson+MG%22">Anderson MG</searchLink>; AbbVie, Oncology Discovery, North Chicago, IL, USA.<br /><searchLink fieldCode="AU" term="%22Williams+SL%22">Williams SL</searchLink>; Sylvester Comprehensive Cancer Center, University of Miami Miller School of Medicine, Miami, FL, USA.; Department of Neurology, University of Miami Miller School of Medicine, Miami, FL, USA.<br /><searchLink fieldCode="AU" term="%22Ivan+ME%22">Ivan ME</searchLink>; Sylvester Comprehensive Cancer Center, University of Miami Miller School of Medicine, Miami, FL, USA.; Department of Neurological Surgery, University of Miami Miller School of Medicine, Miami, FL, USA.<br /><searchLink fieldCode="AU" term="%22Komotar+RJ%22">Komotar RJ</searchLink>; Sylvester Comprehensive Cancer Center, University of Miami Miller School of Medicine, Miami, FL, USA.; Department of Neurological Surgery, University of Miami Miller School of Medicine, Miami, FL, USA.<br /><searchLink fieldCode="AU" term="%22De+La+Fuente+MI%22">De La Fuente MI</searchLink>; Sylvester Comprehensive Cancer Center, University of Miami Miller School of Medicine, Miami, FL, USA.; Department of Neurology, University of Miami Miller School of Medicine, Miami, FL, USA.<br /><searchLink fieldCode="AU" term="%22Stein+G%22">Stein G</searchLink>; Curtana Pharmaceuticals, Inc., Austin, TX, USA.<br /><searchLink fieldCode="AU" term="%22Wojcinski+A%22">Wojcinski A</searchLink>; Pacific Neuroscience Institute and Saint John's Cancer Institute, Providence Health System, Santa Monica, CA, USA.<br /><searchLink fieldCode="AU" term="%22Kesari+S%22">Kesari S</searchLink>; Pacific Neuroscience Institute and Saint John's Cancer Institute, Providence Health System, Santa Monica, CA, USA.; Asthra Health and Lundquist Institute, Santa Monica, CA, USA.<br /><searchLink fieldCode="AU" term="%22Sarkaria+JN%22">Sarkaria JN</searchLink>; Department of Radiation Oncology, Mayo Clinic, Rochester, MN, USA.<br /><searchLink fieldCode="AU" term="%22Schürer+SC%22">Schürer SC</searchLink>; Department of Molecular and Cellular Pharmacology, Institute for Data Science & Computing, University of Miami Miller School of Medicine, Miami, FL, USA.; Sylvester Comprehensive Cancer Center, University of Miami Miller School of Medicine, Miami, FL, USA.<br /><searchLink fieldCode="AU" term="%22Ayad+NG%22">Ayad NG</searchLink>; Department of Oncology, Lombardi Comprehensive Cancer Center, Georgetown University, Washington, DC, USA. NA853@Georgetown.edu.
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  Data: <searchLink fieldCode="JN" term="%22101528555%22">Nature communications</searchLink> [Nat Commun] 2026 Jan 07; Vol. 17 (1), pp. 99. <i>Date of Electronic Publication: </i>2026 Jan 07.
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