Neuro-epithelial circuits promote sensory convergence and intestinal immunity.

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Title: Neuro-epithelial circuits promote sensory convergence and intestinal immunity.
Authors: Zhang W; Jill Roberts Institute for Research in Inflammatory Bowel Disease, Weill Cornell Medicine, Cornell University, New York, NY, USA.; Friedman Center for Nutrition and Inflammation, Weill Cornell Medicine, Cornell University, New York, NY, USA.; Allen Discovery Center for Neuroimmune Interactions, New York, NY, USA.; Department of Microbiology and Immunology, Weill Cornell Medicine, Cornell University, New York, NY, USA.; Joan and Sanford I. Weill Department of Medicine, Division of Gastroenterology and Hepatology, Weill Cornell Medicine, Cornell University, New York, NY, USA., Emanuel ER; Jill Roberts Institute for Research in Inflammatory Bowel Disease, Weill Cornell Medicine, Cornell University, New York, NY, USA.; Friedman Center for Nutrition and Inflammation, Weill Cornell Medicine, Cornell University, New York, NY, USA.; Allen Discovery Center for Neuroimmune Interactions, New York, NY, USA.; Department of Microbiology and Immunology, Weill Cornell Medicine, Cornell University, New York, NY, USA.; Joan and Sanford I. Weill Department of Medicine, Division of Gastroenterology and Hepatology, Weill Cornell Medicine, Cornell University, New York, NY, USA.; Immunology and Microbial Pathogenesis Program, Weill Cornell Medicine, Cornell University, New York, NY, USA., Yano H; Jill Roberts Institute for Research in Inflammatory Bowel Disease, Weill Cornell Medicine, Cornell University, New York, NY, USA.; Friedman Center for Nutrition and Inflammation, Weill Cornell Medicine, Cornell University, New York, NY, USA.; Allen Discovery Center for Neuroimmune Interactions, New York, NY, USA.; Department of Microbiology and Immunology, Weill Cornell Medicine, Cornell University, New York, NY, USA.; Joan and Sanford I. Weill Department of Medicine, Division of Gastroenterology and Hepatology, Weill Cornell Medicine, Cornell University, New York, NY, USA., Uddin J; Jill Roberts Institute for Research in Inflammatory Bowel Disease, Weill Cornell Medicine, Cornell University, New York, NY, USA.; Friedman Center for Nutrition and Inflammation, Weill Cornell Medicine, Cornell University, New York, NY, USA.; Allen Discovery Center for Neuroimmune Interactions, New York, NY, USA.; Department of Microbiology and Immunology, Weill Cornell Medicine, Cornell University, New York, NY, USA.; Joan and Sanford I. Weill Department of Medicine, Division of Gastroenterology and Hepatology, Weill Cornell Medicine, Cornell University, New York, NY, USA., Gaudino S; Jill Roberts Institute for Research in Inflammatory Bowel Disease, Weill Cornell Medicine, Cornell University, New York, NY, USA.; Friedman Center for Nutrition and Inflammation, Weill Cornell Medicine, Cornell University, New York, NY, USA.; Allen Discovery Center for Neuroimmune Interactions, New York, NY, USA.; Department of Microbiology and Immunology, Weill Cornell Medicine, Cornell University, New York, NY, USA.; Joan and Sanford I. Weill Department of Medicine, Division of Gastroenterology and Hepatology, Weill Cornell Medicine, Cornell University, New York, NY, USA., Xie Z; Allen Discovery Center for Neuroimmune Interactions, New York, NY, USA.; The Kimberly and Eric J. Waldman Department of Dermatology, Icahn School of Medicine at Mount Sinai, New York, NY, USA.; Mark Lebwohl Center for Neuroinflammation and Sensation, Icahn School of Medicine at Mount Sinai, New York, NY, USA.; Friedman Brain Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA., Ichise H; Lymphocyte Biology Section, Laboratory of Immune System Biology, NIAID, NIH, Bethesda, MD, USA., Wang Z; Allen Discovery Center for Neuroimmune Interactions, New York, NY, USA.; The Kimberly and Eric J. Waldman Department of Dermatology, Icahn School of Medicine at Mount Sinai, New York, NY, USA.; Mark Lebwohl Center for Neuroinflammation and Sensation, Icahn School of Medicine at Mount Sinai, New York, NY, USA.; Friedman Brain Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA.; Marc and Jennifer Lipschultz Precision Immunology Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA., Cowan MN; Allen Institute for Immunology, Seattle, WA, USA., Lyu M; Jill Roberts Institute for Research in Inflammatory Bowel Disease, Weill Cornell Medicine, Cornell University, New York, NY, USA.; Friedman Center for Nutrition and Inflammation, Weill Cornell Medicine, Cornell University, New York, NY, USA.; Department of Microbiology and Immunology, Weill Cornell Medicine, Cornell University, New York, NY, USA.; Joan and Sanford I. Weill Department of Medicine, Division of Gastroenterology and Hepatology, Weill Cornell Medicine, Cornell University, New York, NY, USA., Hou X; Jill Roberts Institute for Research in Inflammatory Bowel Disease, Weill Cornell Medicine, Cornell University, New York, NY, USA.; Friedman Center for Nutrition and Inflammation, Weill Cornell Medicine, Cornell University, New York, NY, USA.; Allen Discovery Center for Neuroimmune Interactions, New York, NY, USA.; Department of Microbiology and Immunology, Weill Cornell Medicine, Cornell University, New York, NY, USA.; Joan and Sanford I. Weill Department of Medicine, Division of Gastroenterology and Hepatology, Weill Cornell Medicine, Cornell University, New York, NY, USA., Zeng P; Jill Roberts Institute for Research in Inflammatory Bowel Disease, Weill Cornell Medicine, Cornell University, New York, NY, USA.; Friedman Center for Nutrition and Inflammation, Weill Cornell Medicine, Cornell University, New York, NY, USA.; Allen Discovery Center for Neuroimmune Interactions, New York, NY, USA.; Department of Microbiology and Immunology, Weill Cornell Medicine, Cornell University, New York, NY, USA.; Joan and Sanford I. Weill Department of Medicine, Division of Gastroenterology and Hepatology, Weill Cornell Medicine, Cornell University, New York, NY, USA., Hu E; Jill Roberts Institute for Research in Inflammatory Bowel Disease, Weill Cornell Medicine, Cornell University, New York, NY, USA.; Friedman Center for Nutrition and Inflammation, Weill Cornell Medicine, Cornell University, New York, NY, USA.; Allen Discovery Center for Neuroimmune Interactions, New York, NY, USA.; Department of Microbiology and Immunology, Weill Cornell Medicine, Cornell University, New York, NY, USA.; Joan and Sanford I. Weill Department of Medicine, Division of Gastroenterology and Hepatology, Weill Cornell Medicine, Cornell University, New York, NY, USA., Ribeiro de Godoy V; Jill Roberts Institute for Research in Inflammatory Bowel Disease, Weill Cornell Medicine, Cornell University, New York, NY, USA.; Friedman Center for Nutrition and Inflammation, Weill Cornell Medicine, Cornell University, New York, NY, USA.; Allen Discovery Center for Neuroimmune Interactions, New York, NY, USA.; Department of Microbiology and Immunology, Weill Cornell Medicine, Cornell University, New York, NY, USA.; Joan and Sanford I. Weill Department of Medicine, Division of Gastroenterology and Hepatology, Weill Cornell Medicine, Cornell University, New York, NY, USA., Grier A; Jill Roberts Institute for Research in Inflammatory Bowel Disease, Weill Cornell Medicine, Cornell University, New York, NY, USA.; Friedman Center for Nutrition and Inflammation, Weill Cornell Medicine, Cornell University, New York, NY, USA.; Allen Discovery Center for Neuroimmune Interactions, New York, NY, USA.; Department of Microbiology and Immunology, Weill Cornell Medicine, Cornell University, New York, NY, USA.; Joan and Sanford I. Weill Department of Medicine, Division of Gastroenterology and Hepatology, Weill Cornell Medicine, Cornell University, New York, NY, USA., Estep N; Allen Institute for Immunology, Seattle, WA, USA., Ishibashi JR; Allen Institute for Immunology, Seattle, WA, USA., Anover-Sombke S; Allen Institute for Immunology, Seattle, WA, USA., Skene PJ; Allen Institute for Immunology, Seattle, WA, USA., Mayassi T; Broad Institute of MIT and Harvard, Cambridge, MA, USA.; Center for Computational and Integrative Biology, Massachusetts General Hospital and Harvard Medical School, Boston, MA, USA., Xavier RJ; Broad Institute of MIT and Harvard, Cambridge, MA, USA.; Center for Computational and Integrative Biology, Massachusetts General Hospital and Harvard Medical School, Boston, MA, USA., Germain RN; Lymphocyte Biology Section, Laboratory of Immune System Biology, NIAID, NIH, Bethesda, MD, USA., Globig AM; Allen Institute for Immunology, Seattle, WA, USA., Heeg M; Allen Institute for Immunology, Seattle, WA, USA., Goldrath AW; Allen Institute for Immunology, Seattle, WA, USA.; School of Biological Sciences, Department of Molecular Biology, University of California, San Diego, La Jolla, CA, USA., Kim BS; Allen Discovery Center for Neuroimmune Interactions, New York, NY, USA.; The Kimberly and Eric J. Waldman Department of Dermatology, Icahn School of Medicine at Mount Sinai, New York, NY, USA.; Mark Lebwohl Center for Neuroinflammation and Sensation, Icahn School of Medicine at Mount Sinai, New York, NY, USA.; Friedman Brain Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA.; Marc and Jennifer Lipschultz Precision Immunology Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA., Hu H; Allen Discovery Center for Neuroimmune Interactions, New York, NY, USA.; The Kimberly and Eric J. Waldman Department of Dermatology, Icahn School of Medicine at Mount Sinai, New York, NY, USA.; Mark Lebwohl Center for Neuroinflammation and Sensation, Icahn School of Medicine at Mount Sinai, New York, NY, USA.; Friedman Brain Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA., Artis D; Jill Roberts Institute for Research in Inflammatory Bowel Disease, Weill Cornell Medicine, Cornell University, New York, NY, USA. dartis@med.cornell.edu.; Friedman Center for Nutrition and Inflammation, Weill Cornell Medicine, Cornell University, New York, NY, USA. dartis@med.cornell.edu.; Allen Discovery Center for Neuroimmune Interactions, New York, NY, USA. dartis@med.cornell.edu.; Department of Microbiology and Immunology, Weill Cornell Medicine, Cornell University, New York, NY, USA. dartis@med.cornell.edu.; Joan and Sanford I. Weill Department of Medicine, Division of Gastroenterology and Hepatology, Weill Cornell Medicine, Cornell University, New York, NY, USA. dartis@med.cornell.edu.; Immunology and Microbial Pathogenesis Program, Weill Cornell Medicine, Cornell University, New York, NY, USA. dartis@med.cornell.edu.; The Parker Institute for Cancer Immunotherapy, Weill Cornell Medicine, Cornell University, New York, NY, USA. dartis@med.cornell.edu.
Source: Nature [Nature] 2026 Mar; Vol. 651 (8105), pp. 440-450. Date of Electronic Publication: 2026 Jan 07.
Publication Type: Journal Article; Research Support, N.I.H., Extramural
Journal Info: Publisher: Nature Publishing Group Country of Publication: England NLM ID: 0410462 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1476-4687 (Electronic) Linking ISSN: 00280836 NLM ISO Abbreviation: Nature Subsets: MEDLINE
Database: MEDLINE Ultimate
Description
ISSN:1476-4687
DOI:10.1038/s41586-025-09921-z