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Cocrystal-inspired glycyrrhizic acid-azole nanoassemblies for synergistic biofilm disruption and immune modulation in fungal infections.

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Title: Cocrystal-inspired glycyrrhizic acid-azole nanoassemblies for synergistic biofilm disruption and immune modulation in fungal infections.
Authors: Wang C; Wenzhou TCM Hospital of Zhejiang Chinese Medical University, Wenzhou, Zhejiang, 325000, China., Gao C; Wenzhou TCM Hospital of Zhejiang Chinese Medical University, Wenzhou, Zhejiang, 325000, China.; Translational Medicine Laboratory Consortium for Infection and Innovation (CII), the First Affiliated Hospital of Wenzhou Medical University, Wenzhou, Zhejiang, 325035, China.; Wenzhou Institute, University of the Chinese Academy of Sciences, Wenzhou, Zhejiang, 325001, China., Qian L; Wenzhou TCM Hospital of Zhejiang Chinese Medical University, Wenzhou, Zhejiang, 325000, China.; Translational Medicine Laboratory Consortium for Infection and Innovation (CII), the First Affiliated Hospital of Wenzhou Medical University, Wenzhou, Zhejiang, 325035, China.; Wenzhou Institute, University of the Chinese Academy of Sciences, Wenzhou, Zhejiang, 325001, China., Chen M; People's Hospital of Taishun Zhejiang Chinese Medical University, Zhejiang, 324003, China., Li Y; Translational Medicine Laboratory Consortium for Infection and Innovation (CII), the First Affiliated Hospital of Wenzhou Medical University, Wenzhou, Zhejiang, 325035, China., Ye S; Wenzhou TCM Hospital of Zhejiang Chinese Medical University, Wenzhou, Zhejiang, 325000, China., Cai W; Department of TCM Science and Research Center, Wenzhou TCM Hospital of Zhejiang Chinese Medical University, Wenzhou, Zhejiang, 325000, China., Xu T; Department of Anorectal Surgery , The Quzhou Affiliated Hospital of Wenzhou Medical University Quzhou People's Hospital , Quzhou, Zhejiang, 324003, China., Zheng L; Wenzhou Institute, University of the Chinese Academy of Sciences, Wenzhou, Zhejiang, 325001, China. Zhenglf@ucas.ac.cn., Liu Y; Translational Medicine Laboratory Consortium for Infection and Innovation (CII), the First Affiliated Hospital of Wenzhou Medical University, Wenzhou, Zhejiang, 325035, China. y.liu@nankai.edu.cn.; Wenzhou Institute, University of the Chinese Academy of Sciences, Wenzhou, Zhejiang, 325001, China. y.liu@nankai.edu.cn.; State Key Laboratory of Medicinal Chemical Biology, Nankai University, Tianjin, 300071, China. y.liu@nankai.edu.cn.; State Key Laboratory of Advanced Polymer Materials, Sichuan University, Chengdu, Sichuan, 610065, China. y.liu@nankai.edu.cn., Chen Y; Department of Obstetrics and Gynecology, The Second Affiliated Hospital of Wenzhou Medical University, Wenzhou, 325027, China. chenyijie@wmu.edu.cn., Shi L; State Key Laboratory of Medicinal Chemical Biology, Nankai University, Tianjin, 300071, China., Zhao L; Department of Anorectal Surgery , The Quzhou Affiliated Hospital of Wenzhou Medical University Quzhou People's Hospital , Quzhou, Zhejiang, 324003, China. zhaolei119923@126.com.
Source: Journal of nanobiotechnology [J Nanobiotechnology] 2026 Jan 07; Vol. 24 (1), pp. 115. Date of Electronic Publication: 2026 Jan 07.
Publication Type: Journal Article
Journal Info: Publisher: BioMed Central Country of Publication: England NLM ID: 101152208 Publication Model: Electronic Cited Medium: Internet ISSN: 1477-3155 (Electronic) Linking ISSN: 14773155 NLM ISO Abbreviation: J Nanobiotechnology Subsets: MEDLINE
Database: MEDLINE Ultimate
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  Data: Cocrystal-inspired glycyrrhizic acid-azole nanoassemblies for synergistic biofilm disruption and immune modulation in fungal infections.
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  Data: <searchLink fieldCode="AU" term="%22Wang+C%22">Wang C</searchLink>; Wenzhou TCM Hospital of Zhejiang Chinese Medical University, Wenzhou, Zhejiang, 325000, China.<br /><searchLink fieldCode="AU" term="%22Gao+C%22">Gao C</searchLink>; Wenzhou TCM Hospital of Zhejiang Chinese Medical University, Wenzhou, Zhejiang, 325000, China.; Translational Medicine Laboratory Consortium for Infection and Innovation (CII), the First Affiliated Hospital of Wenzhou Medical University, Wenzhou, Zhejiang, 325035, China.; Wenzhou Institute, University of the Chinese Academy of Sciences, Wenzhou, Zhejiang, 325001, China.<br /><searchLink fieldCode="AU" term="%22Qian+L%22">Qian L</searchLink>; Wenzhou TCM Hospital of Zhejiang Chinese Medical University, Wenzhou, Zhejiang, 325000, China.; Translational Medicine Laboratory Consortium for Infection and Innovation (CII), the First Affiliated Hospital of Wenzhou Medical University, Wenzhou, Zhejiang, 325035, China.; Wenzhou Institute, University of the Chinese Academy of Sciences, Wenzhou, Zhejiang, 325001, China.<br /><searchLink fieldCode="AU" term="%22Chen+M%22">Chen M</searchLink>; People's Hospital of Taishun Zhejiang Chinese Medical University, Zhejiang, 324003, China.<br /><searchLink fieldCode="AU" term="%22Li+Y%22">Li Y</searchLink>; Translational Medicine Laboratory Consortium for Infection and Innovation (CII), the First Affiliated Hospital of Wenzhou Medical University, Wenzhou, Zhejiang, 325035, China.<br /><searchLink fieldCode="AU" term="%22Ye+S%22">Ye S</searchLink>; Wenzhou TCM Hospital of Zhejiang Chinese Medical University, Wenzhou, Zhejiang, 325000, China.<br /><searchLink fieldCode="AU" term="%22Cai+W%22">Cai W</searchLink>; Department of TCM Science and Research Center, Wenzhou TCM Hospital of Zhejiang Chinese Medical University, Wenzhou, Zhejiang, 325000, China.<br /><searchLink fieldCode="AU" term="%22Xu+T%22">Xu T</searchLink>; Department of Anorectal Surgery , The Quzhou Affiliated Hospital of Wenzhou Medical University Quzhou People's Hospital , Quzhou, Zhejiang, 324003, China.<br /><searchLink fieldCode="AU" term="%22Zheng+L%22">Zheng L</searchLink>; Wenzhou Institute, University of the Chinese Academy of Sciences, Wenzhou, Zhejiang, 325001, China. Zhenglf@ucas.ac.cn.<br /><searchLink fieldCode="AU" term="%22Liu+Y%22">Liu Y</searchLink>; Translational Medicine Laboratory Consortium for Infection and Innovation (CII), the First Affiliated Hospital of Wenzhou Medical University, Wenzhou, Zhejiang, 325035, China. y.liu@nankai.edu.cn.; Wenzhou Institute, University of the Chinese Academy of Sciences, Wenzhou, Zhejiang, 325001, China. y.liu@nankai.edu.cn.; State Key Laboratory of Medicinal Chemical Biology, Nankai University, Tianjin, 300071, China. y.liu@nankai.edu.cn.; State Key Laboratory of Advanced Polymer Materials, Sichuan University, Chengdu, Sichuan, 610065, China. y.liu@nankai.edu.cn.<br /><searchLink fieldCode="AU" term="%22Chen+Y%22">Chen Y</searchLink>; Department of Obstetrics and Gynecology, The Second Affiliated Hospital of Wenzhou Medical University, Wenzhou, 325027, China. chenyijie@wmu.edu.cn.<br /><searchLink fieldCode="AU" term="%22Shi+L%22">Shi L</searchLink>; State Key Laboratory of Medicinal Chemical Biology, Nankai University, Tianjin, 300071, China.<br /><searchLink fieldCode="AU" term="%22Zhao+L%22">Zhao L</searchLink>; Department of Anorectal Surgery , The Quzhou Affiliated Hospital of Wenzhou Medical University Quzhou People's Hospital , Quzhou, Zhejiang, 324003, China. zhaolei119923@126.com.
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        Value: 10.1186/s12951-025-04014-5
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        Text: English
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              Text: 2026 Jan 07
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