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Advancing patient stratification in major depressive disorder: Evaluation of clinical staging and machine learning prediction models based on real-world data.

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Bibliographic Details
Title: Advancing patient stratification in major depressive disorder: Evaluation of clinical staging and machine learning prediction models based on real-world data.
Authors: Reneses B; Institute of biomedical research IdISSC, Hospital Clínico San Carlos, Madrid, Spain; CIBERSAM (Centro de Investigación Biomédica en Red de Salud Mental), Spain; Complutense University, School of Medicine (UCM), Madrid, Spain. Electronic address: blanca@reneses.es., García-Huéscar M; Institute of biomedical research IdISSC, Hospital Clínico San Carlos, Madrid, Spain; Laboratory for Clinical Neuroscience, Centre for Biomedical Technology, Universidad Politécnica de Madrid, Spain., Argudo I; Institute of Psychiatry and Mental Health, Hospital Clínico San Carlos, Madrid, Spain., Machin M; Complutense University, School of Medicine (UCM), Madrid, Spain; Institute of Psychiatry and Mental Health, Hospital Clínico San Carlos, Madrid, Spain., Bravo G; Institute of biomedical research IdISSC, Hospital Clínico San Carlos, Madrid, Spain; CIBERCV ((Centro de Investigación Biomédica en Red de Enfermedades Cardiovasculares), Spain., Saz M; Institute of biomedical research IdISSC, Hospital Clínico San Carlos, Madrid, Spain., Zamarro ML; Complutense University, School of Medicine (UCM), Madrid, Spain; Institute of Psychiatry and Mental Health, Hospital Clínico San Carlos, Madrid, Spain., Díaz-Marsá M; Institute of biomedical research IdISSC, Hospital Clínico San Carlos, Madrid, Spain; CIBERSAM (Centro de Investigación Biomédica en Red de Salud Mental), Spain; Complutense University, School of Medicine (UCM), Madrid, Spain; Institute of Psychiatry and Mental Health, Hospital Clínico San Carlos, Madrid, Spain., Fraguas D; Institute of biomedical research IdISSC, Hospital Clínico San Carlos, Madrid, Spain; CIBERSAM (Centro de Investigación Biomédica en Red de Salud Mental), Spain; Complutense University, School of Medicine (UCM), Madrid, Spain; Institute of Psychiatry and Mental Health, Hospital Clínico San Carlos, Madrid, Spain.
Source: Journal of affective disorders [J Affect Disord] 2026 May 01; Vol. 400, pp. 121128. Date of Electronic Publication: 2026 Jan 06.
Publication Type: Journal Article; Observational Study
Journal Info: Publisher: Elsevier/North-Holland Biomedical Press Country of Publication: Netherlands NLM ID: 7906073 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1573-2517 (Electronic) Linking ISSN: 01650327 NLM ISO Abbreviation: J Affect Disord Subsets: MEDLINE
Database: MEDLINE Ultimate
Description
ISSN:1573-2517
DOI:10.1016/j.jad.2025.121128