Design and rationale of the GUARD-OAC: A randomized controlled trial evaluating proton pump inhibitor cotherapy for gastrointestinal protection in patients requiring direct oral anticoagulants.
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| Title: | Design and rationale of the GUARD-OAC: A randomized controlled trial evaluating proton pump inhibitor cotherapy for gastrointestinal protection in patients requiring direct oral anticoagulants. |
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| Authors: | Ahn HJ; Department of Internal Medicine, Seoul National University Hospital, Seoul, Republic of Korea., Lee SR; Department of Internal Medicine, Seoul National University Hospital, Seoul, Republic of Korea; Department of Internal Medicine, Seoul National University College of Medicine, Seoul, Republic of Korea., Kwon S; Department of Internal Medicine, Seoul Metropolitan Government Seoul National University Boramae Medical Center, Seoul, Republic of Korea., Rhee TM; Department of Internal Medicine, Seoul National University Hospital Healthcare System Gangnam Center, Seoul, Republic of Korea., Lee YS; Department of Cardiology, Daegu Catholic University Medical Center, Daegu, Republic of Korea., Han SJ; Department of Internal Medicine, College of Medicine, Hallym University, Anyang, Republic of Korea., Kang KW; Department of Internal Medicine, Division of Cardiology, Chung-Ang University Hospital, College of Medicine, Seoul, Republic of Korea., Shim J; Department of Internal Medicine, Division of Cardiology, Korea University College of Medicine and Korea University Anam Hospital, Seoul, Republic of Korea., Yu HT; Department of Internal Medicine, Division of Cardiology, Yonsei University College of Medicine, Yonsei University Health System, Seoul, Republic of Korea., Oh IY; Department of Internal Medicine, Seoul National University College of Medicine, Seoul, Republic of Korea; Department of Cardiology, Cardiovascular Centre, Seoul National University Bundang Hospital, Seongnam, Republic of Korea., Park HS; Department of Internal Medicine, Division of Cardiology, Keimyung University Dongsan Hospital, Daegu, Republic of Korea., Park JK; Department of Internal Medicine, Division of Cardiology, Hanyang University Seoul Hospital, Seoul, Republic of Korea., Jang SW; Department of Internal Medicine, Eunpyeong St. Mary's Hospital, College of Medicine, Division of Cardiology, The Catholic University of Korea, Seoul, Republic of Korea., Lee SH; Department of Internal Medicine, Kangbuk Samsung Hospital, Division of Cardiology, Sungkyunkwan University School of Medicine, Seoul, Republic of Korea., Roh SY; Department of Internal Medicine, Division of Cardiology, Korea University Medicine Guro hospital, Seoul, Republic of Korea., Chun KJ; Department of Internal Medicine, Division of Cardiology, Kangwon National University Hospital, Kangwon National University School of Medicine, Chuncheon, Republic of Korea., Park HW; Department of Cardiovascular Medicine, Chonnam National University Hospital, Gwangju, Republic of Korea., Lee KY; Department of Internal Medicine, Seoul National University College of Medicine, Seoul, Republic of Korea; Department of Internal Medicine, Division of Cardiology, Korea University Medicine Guro hospital, Seoul, Republic of Korea., Oh S; Department of Internal Medicine, Seoul National University Hospital, Seoul, Republic of Korea; Department of Internal Medicine, Seoul National University College of Medicine, Seoul, Republic of Korea., Choi EK; Department of Internal Medicine, Seoul National University Hospital, Seoul, Republic of Korea; Department of Internal Medicine, Seoul National University College of Medicine, Seoul, Republic of Korea. Electronic address: choiek17@snu.ac.kr. |
| Corporate Authors: | GUARD-OAC Trial Investigators |
| Source: | American heart journal [Am Heart J] 2026 May; Vol. 295, pp. 107341. Date of Electronic Publication: 2026 Jan 06. |
| Publication Type: | Journal Article; Clinical Trial Protocol |
| Journal Info: | Publisher: Mosby Country of Publication: United States NLM ID: 0370465 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1097-6744 (Electronic) Linking ISSN: 00028703 NLM ISO Abbreviation: Am Heart J Subsets: MEDLINE |
| Database: | MEDLINE Ultimate |
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