Protective effects of Prunella vulgaris polysaccharides against herpes simplex virus type 1 infection through the STING-TBK1-IRF3 pathway.

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Title: Protective effects of Prunella vulgaris polysaccharides against herpes simplex virus type 1 infection through the STING-TBK1-IRF3 pathway.
Authors: Zhang YB; School of Pharmacy, Shanghai University of Traditional Chinese Medicine, Shanghai 201203, China; Engineering Research Center, Shanghai Colleges for TCM New Drug Discovery, Shanghai 201203, China., Xu L; School of Pharmacy, Shanghai University of Traditional Chinese Medicine, Shanghai 201203, China; Engineering Research Center, Shanghai Colleges for TCM New Drug Discovery, Shanghai 201203, China., Yuan M; School of Pharmacy, Shanghai University of Traditional Chinese Medicine, Shanghai 201203, China; Engineering Research Center, Shanghai Colleges for TCM New Drug Discovery, Shanghai 201203, China., Liu MF; School of Pharmacy, Shanghai University of Traditional Chinese Medicine, Shanghai 201203, China; Engineering Research Center, Shanghai Colleges for TCM New Drug Discovery, Shanghai 201203, China., Li Y; School of Pharmacy, Shanghai University of Traditional Chinese Medicine, Shanghai 201203, China; Engineering Research Center, Shanghai Colleges for TCM New Drug Discovery, Shanghai 201203, China., Zhong XL; School of Pharmacy, Shanghai University of Traditional Chinese Medicine, Shanghai 201203, China; Engineering Research Center, Shanghai Colleges for TCM New Drug Discovery, Shanghai 201203, China., Lin ZX; School of Chinese Medicine, Faculty of Medicine, the Chinese University of Hong Kong, Hong Kong 999077, China., Xian YF; School of Chinese Medicine, Faculty of Medicine, the Chinese University of Hong Kong, Hong Kong 999077, China., Lu P; School of Pharmacy, Shanghai University of Traditional Chinese Medicine, Shanghai 201203, China; Engineering Research Center, Shanghai Colleges for TCM New Drug Discovery, Shanghai 201203, China., Xi ZC; School of Pharmacy, Shanghai University of Traditional Chinese Medicine, Shanghai 201203, China; Engineering Research Center, Shanghai Colleges for TCM New Drug Discovery, Shanghai 201203, China. Electronic address: xizhichaohaerbin@163.com., Xu HX; School of Pharmacy, Shanghai University of Traditional Chinese Medicine, Shanghai 201203, China; Engineering Research Center, Shanghai Colleges for TCM New Drug Discovery, Shanghai 201203, China. Electronic address: hxxu@shutcm.edu.cn.
Source: Journal of integrative medicine [J Integr Med] 2026 May; Vol. 24 (3), pp. 454-465. Date of Electronic Publication: 2025 Dec 29.
Publication Type: Journal Article
Journal Info: Publisher: Elsevier B.V Country of Publication: Netherlands NLM ID: 101603118 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 2095-4964 (Print) NLM ISO Abbreviation: J Integr Med Subsets: MEDLINE
Database: MEDLINE Ultimate
Description
ISSN:2095-4964
DOI:10.1016/j.joim.2025.12.008