Protective effects of Prunella vulgaris polysaccharides against herpes simplex virus type 1 infection through the STING-TBK1-IRF3 pathway.

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Title: Protective effects of Prunella vulgaris polysaccharides against herpes simplex virus type 1 infection through the STING-TBK1-IRF3 pathway.
Authors: Zhang YB; School of Pharmacy, Shanghai University of Traditional Chinese Medicine, Shanghai 201203, China; Engineering Research Center, Shanghai Colleges for TCM New Drug Discovery, Shanghai 201203, China., Xu L; School of Pharmacy, Shanghai University of Traditional Chinese Medicine, Shanghai 201203, China; Engineering Research Center, Shanghai Colleges for TCM New Drug Discovery, Shanghai 201203, China., Yuan M; School of Pharmacy, Shanghai University of Traditional Chinese Medicine, Shanghai 201203, China; Engineering Research Center, Shanghai Colleges for TCM New Drug Discovery, Shanghai 201203, China., Liu MF; School of Pharmacy, Shanghai University of Traditional Chinese Medicine, Shanghai 201203, China; Engineering Research Center, Shanghai Colleges for TCM New Drug Discovery, Shanghai 201203, China., Li Y; School of Pharmacy, Shanghai University of Traditional Chinese Medicine, Shanghai 201203, China; Engineering Research Center, Shanghai Colleges for TCM New Drug Discovery, Shanghai 201203, China., Zhong XL; School of Pharmacy, Shanghai University of Traditional Chinese Medicine, Shanghai 201203, China; Engineering Research Center, Shanghai Colleges for TCM New Drug Discovery, Shanghai 201203, China., Lin ZX; School of Chinese Medicine, Faculty of Medicine, the Chinese University of Hong Kong, Hong Kong 999077, China., Xian YF; School of Chinese Medicine, Faculty of Medicine, the Chinese University of Hong Kong, Hong Kong 999077, China., Lu P; School of Pharmacy, Shanghai University of Traditional Chinese Medicine, Shanghai 201203, China; Engineering Research Center, Shanghai Colleges for TCM New Drug Discovery, Shanghai 201203, China., Xi ZC; School of Pharmacy, Shanghai University of Traditional Chinese Medicine, Shanghai 201203, China; Engineering Research Center, Shanghai Colleges for TCM New Drug Discovery, Shanghai 201203, China. Electronic address: xizhichaohaerbin@163.com., Xu HX; School of Pharmacy, Shanghai University of Traditional Chinese Medicine, Shanghai 201203, China; Engineering Research Center, Shanghai Colleges for TCM New Drug Discovery, Shanghai 201203, China. Electronic address: hxxu@shutcm.edu.cn.
Source: Journal of integrative medicine [J Integr Med] 2026 May; Vol. 24 (3), pp. 454-465. Date of Electronic Publication: 2025 Dec 29.
Publication Type: Journal Article
Journal Info: Publisher: Elsevier B.V Country of Publication: Netherlands NLM ID: 101603118 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 2095-4964 (Print) NLM ISO Abbreviation: J Integr Med Subsets: MEDLINE
Database: MEDLINE Ultimate
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  Data: Protective effects of Prunella vulgaris polysaccharides against herpes simplex virus type 1 infection through the STING-TBK1-IRF3 pathway.
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  Data: <searchLink fieldCode="AU" term="%22Zhang+YB%22">Zhang YB</searchLink>; School of Pharmacy, Shanghai University of Traditional Chinese Medicine, Shanghai 201203, China; Engineering Research Center, Shanghai Colleges for TCM New Drug Discovery, Shanghai 201203, China.<br /><searchLink fieldCode="AU" term="%22Xu+L%22">Xu L</searchLink>; School of Pharmacy, Shanghai University of Traditional Chinese Medicine, Shanghai 201203, China; Engineering Research Center, Shanghai Colleges for TCM New Drug Discovery, Shanghai 201203, China.<br /><searchLink fieldCode="AU" term="%22Yuan+M%22">Yuan M</searchLink>; School of Pharmacy, Shanghai University of Traditional Chinese Medicine, Shanghai 201203, China; Engineering Research Center, Shanghai Colleges for TCM New Drug Discovery, Shanghai 201203, China.<br /><searchLink fieldCode="AU" term="%22Liu+MF%22">Liu MF</searchLink>; School of Pharmacy, Shanghai University of Traditional Chinese Medicine, Shanghai 201203, China; Engineering Research Center, Shanghai Colleges for TCM New Drug Discovery, Shanghai 201203, China.<br /><searchLink fieldCode="AU" term="%22Li+Y%22">Li Y</searchLink>; School of Pharmacy, Shanghai University of Traditional Chinese Medicine, Shanghai 201203, China; Engineering Research Center, Shanghai Colleges for TCM New Drug Discovery, Shanghai 201203, China.<br /><searchLink fieldCode="AU" term="%22Zhong+XL%22">Zhong XL</searchLink>; School of Pharmacy, Shanghai University of Traditional Chinese Medicine, Shanghai 201203, China; Engineering Research Center, Shanghai Colleges for TCM New Drug Discovery, Shanghai 201203, China.<br /><searchLink fieldCode="AU" term="%22Lin+ZX%22">Lin ZX</searchLink>; School of Chinese Medicine, Faculty of Medicine, the Chinese University of Hong Kong, Hong Kong 999077, China.<br /><searchLink fieldCode="AU" term="%22Xian+YF%22">Xian YF</searchLink>; School of Chinese Medicine, Faculty of Medicine, the Chinese University of Hong Kong, Hong Kong 999077, China.<br /><searchLink fieldCode="AU" term="%22Lu+P%22">Lu P</searchLink>; School of Pharmacy, Shanghai University of Traditional Chinese Medicine, Shanghai 201203, China; Engineering Research Center, Shanghai Colleges for TCM New Drug Discovery, Shanghai 201203, China.<br /><searchLink fieldCode="AU" term="%22Xi+ZC%22">Xi ZC</searchLink>; School of Pharmacy, Shanghai University of Traditional Chinese Medicine, Shanghai 201203, China; Engineering Research Center, Shanghai Colleges for TCM New Drug Discovery, Shanghai 201203, China. Electronic address: xizhichaohaerbin@163.com.<br /><searchLink fieldCode="AU" term="%22Xu+HX%22">Xu HX</searchLink>; School of Pharmacy, Shanghai University of Traditional Chinese Medicine, Shanghai 201203, China; Engineering Research Center, Shanghai Colleges for TCM New Drug Discovery, Shanghai 201203, China. Electronic address: hxxu@shutcm.edu.cn.
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  Data: <searchLink fieldCode="JN" term="%22101603118%22">Journal of integrative medicine</searchLink> [J Integr Med] 2026 May; Vol. 24 (3), pp. 454-465. <i>Date of Electronic Publication: </i>2025 Dec 29.
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  Data: <i>Publisher: </i><searchLink fieldCode="PB" term="%22Elsevier+B%2EV%22">Elsevier B.V </searchLink><i>Country of Publication: </i>Netherlands <i>NLM ID: </i>101603118 <i>Publication Model: </i>Print-Electronic <i>Cited Medium: </i>Internet <i>ISSN: </i>2095-4964 (Print) <i>NLM ISO Abbreviation: </i>J Integr Med <i>Subsets: </i>MEDLINE
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        Value: 10.1016/j.joim.2025.12.008
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        Text: English
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      – TitleFull: Protective effects of Prunella vulgaris polysaccharides against herpes simplex virus type 1 infection through the STING-TBK1-IRF3 pathway.
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              Text: 2026 May
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