Integrative transcriptome-wide association analyses reveal PRKCG-linked GABAergic dysfunction in Fragile X-associated tremor/ataxia syndrome.

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Title: Integrative transcriptome-wide association analyses reveal PRKCG-linked GABAergic dysfunction in Fragile X-associated tremor/ataxia syndrome.
Authors: Jin Y; Department of Human Genetics, School of Medicine, Emory University, Atlanta, GA, USA., Cao Y; Department of Human Genetics, School of Medicine, Emory University, Atlanta, GA, USA.; Department of Neurology, Xiangya Hospital, Central South University, Changsha, Hunan, China., Ma W; Department of Biostatistics, School of Public Health, University of Michigan, Ann Arbor, MI, USA., Li R; Department of Human Genetics, School of Medicine, Emory University, Atlanta, GA, USA., Li Y; Department of Human Genetics, School of Medicine, Emory University, Atlanta, GA, USA., Kang Y; Department of Human Genetics, School of Medicine, Emory University, Atlanta, GA, USA., Huang J; Department of Human Genetics, School of Medicine, Emory University, Atlanta, GA, USA., Epstein MP; Department of Human Genetics, School of Medicine, Emory University, Atlanta, GA, USA., Guo X; Department of Human Genetics, School of Medicine, Emory University, Atlanta, GA, USA., Lim J; Department of Human Genetics, School of Medicine, Emory University, Atlanta, GA, USA., Rivera N; Department of Human Genetics, School of Medicine, Emory University, Atlanta, GA, USA., Zhou Y; Department of Psychiatry and Behavioral Sciences, School of Medicine, Emory University, Atlanta, GA, USA., Wen Z; Department of Human Genetics, School of Medicine, Emory University, Atlanta, GA, USA.; Department of Psychiatry and Behavioral Sciences, School of Medicine, Emory University, Atlanta, GA, USA.; Department of Cell Biology, School of Medicine, Emory University, Atlanta, GA, USA.; Department of Neurology, School of Medicine, Emory University, Atlanta, GA, USA., Allen EG; Department of Human Genetics, School of Medicine, Emory University, Atlanta, GA, USA., Jin P; Department of Human Genetics, School of Medicine, Emory University, Atlanta, GA, USA. peng.jin@emory.edu.
Source: Nature communications [Nat Commun] 2026 Jan 08; Vol. 17 (1), pp. 1418. Date of Electronic Publication: 2026 Jan 08.
Publication Type: Journal Article
Journal Info: Publisher: Nature Pub. Group Country of Publication: England NLM ID: 101528555 Publication Model: Electronic Cited Medium: Internet ISSN: 2041-1723 (Electronic) Linking ISSN: 20411723 NLM ISO Abbreviation: Nat Commun Subsets: MEDLINE
Database: MEDLINE Ultimate
Description
ISSN:2041-1723
DOI:10.1038/s41467-025-68163-9