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NSD2 upregulation is driven by high-risk HPV E6/E7 and disrupts epithelial differentiation in HPV-associated head and neck cancer.

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Title: NSD2 upregulation is driven by high-risk HPV E6/E7 and disrupts epithelial differentiation in HPV-associated head and neck cancer.
Authors: Ghiani L; Department of Experimental Oncology, IEO, European Institute of Oncology IRCCS, via Adamello 16, Milan, 20139, Italy., Citro S; Department of Experimental Oncology, IEO, European Institute of Oncology IRCCS, via Adamello 16, Milan, 20139, Italy., Medda A; Department of Experimental Oncology, IEO, European Institute of Oncology IRCCS, via Adamello 16, Milan, 20139, Italy., Doni M; Department of Experimental Oncology, IEO, European Institute of Oncology IRCCS, via Adamello 16, Milan, 20139, Italy., Ghoryani F; Department of Experimental Oncology, IEO, European Institute of Oncology IRCCS, via Adamello 16, Milan, 20139, Italy., Noberini R; Department of Experimental Oncology, IEO, European Institute of Oncology IRCCS, via Adamello 16, Milan, 20139, Italy., Croci O; Center for Genomic Science of IIT, CGS@SEMM (Istituto Italiano di Tecnologia at European School of Molecular Medicine), Fondazione Istituto Italiano di Tecnologia (IIT), Milan, Italy., Maffini F; Department of Surgical Pathology, European Institute of Oncology IRCCS, Milan, 20141, Italy., Miccolo C; Department of Experimental Oncology, IEO, European Institute of Oncology IRCCS, via Adamello 16, Milan, 20139, Italy., Monteleone L; Department of Experimental Oncology, IEO, European Institute of Oncology IRCCS, via Adamello 16, Milan, 20139, Italy., Tagliabue M; Department of Otorhinolaryngology and Head and Neck Surgery, European Institute of Oncology, IRCCS, Via Ripamonti 435, Milan, 20141, Italy., De Berardinis R; Department of Otorhinolaryngology and Head and Neck Surgery, European Institute of Oncology, IRCCS, Via Ripamonti 435, Milan, 20141, Italy., Campaner S; Center for Genomic Science of IIT, CGS@SEMM (Istituto Italiano di Tecnologia at European School of Molecular Medicine), Fondazione Istituto Italiano di Tecnologia (IIT), Milan, Italy.; Department of Molecular Medicine, University of Padua, Padua, Italy., Bonaldi T; Department of Experimental Oncology, IEO, European Institute of Oncology IRCCS, via Adamello 16, Milan, 20139, Italy.; Department of Oncology and Haemato-Oncology (DIPO), University of Milano, Via Santa Sofia 9/1, Milano, 20121, Italy., Ansarin M; Department of Otorhinolaryngology and Head and Neck Surgery, European Institute of Oncology, IRCCS, Via Ripamonti 435, Milan, 20141, Italy., Chiocca S; Department of Experimental Oncology, IEO, European Institute of Oncology IRCCS, via Adamello 16, Milan, 20139, Italy. susanna.chiocca@ieo.it.
Source: Journal of experimental & clinical cancer research : CR [J Exp Clin Cancer Res] 2026 Jan 08; Vol. 45 (1), pp. 40. Date of Electronic Publication: 2026 Jan 08.
Publication Type: Journal Article
Journal Info: Publisher: BioMed Central Country of Publication: England NLM ID: 8308647 Publication Model: Electronic Cited Medium: Internet ISSN: 1756-9966 (Electronic) Linking ISSN: 03929078 NLM ISO Abbreviation: J Exp Clin Cancer Res Subsets: MEDLINE
Database: MEDLINE Ultimate
Description
ISSN:1756-9966
DOI:10.1186/s13046-025-03631-0