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Senolytic reduction of senescent cells mitigates atrial arrhythmia vulnerability in aging rabbits.

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Title: Senolytic reduction of senescent cells mitigates atrial arrhythmia vulnerability in aging rabbits.
Authors: Sengun E; The Warren Alpert Medical School of Brown University, Providence, Rhode Island; Cardiovascular Research Center, Rhode Island Hospital, Providence, Rhode Island; Department of Pharmacology, Institute of Graduate Studies in Health Sciences, Istanbul University, Istanbul, Türkiye., Zhou L; The Warren Alpert Medical School of Brown University, Providence, Rhode Island; Cardiovascular Research Center, Rhode Island Hospital, Providence, Rhode Island., Kelsey M; Department of Molecular Biology, Cell Biology and Biochemistry, Brown University, Providence, Rhode Island., Turan NN; The Warren Alpert Medical School of Brown University, Providence, Rhode Island; Cardiovascular Research Center, Rhode Island Hospital, Providence, Rhode Island; School of Nursing and Health Sciences, Providence College, Providence, Rhode Island., Lu Y; Cardiovascular Research Center, Rhode Island Hospital, Providence, Rhode Island., Kabakov AY; The Warren Alpert Medical School of Brown University, Providence, Rhode Island; Cardiovascular Research Center, Rhode Island Hospital, Providence, Rhode Island., Bronk P; The Warren Alpert Medical School of Brown University, Providence, Rhode Island; Cardiovascular Research Center, Rhode Island Hospital, Providence, Rhode Island., Mi E; The Warren Alpert Medical School of Brown University, Providence, Rhode Island; Cardiovascular Research Center, Rhode Island Hospital, Providence, Rhode Island., Kim TY; The Warren Alpert Medical School of Brown University, Providence, Rhode Island; Cardiovascular Research Center, Rhode Island Hospital, Providence, Rhode Island., Vijayakumar S; The Warren Alpert Medical School of Brown University, Providence, Rhode Island; Cardiovascular Research Center, Rhode Island Hospital, Providence, Rhode Island., Price D; The Warren Alpert Medical School of Brown University, Providence, Rhode Island; Cardiovascular Research Center, Rhode Island Hospital, Providence, Rhode Island., Nussbaum SS; The Warren Alpert Medical School of Brown University, Providence, Rhode Island; Cardiovascular Research Center, Rhode Island Hospital, Providence, Rhode Island., Song C; The Warren Alpert Medical School of Brown University, Providence, Rhode Island; Cardiovascular Research Center, Rhode Island Hospital, Providence, Rhode Island., Feng J; The Warren Alpert Medical School of Brown University, Providence, Rhode Island; Cardiovascular Research Center, Rhode Island Hospital, Providence, Rhode Island., Sellke FW; The Warren Alpert Medical School of Brown University, Providence, Rhode Island; Cardiovascular Research Center, Rhode Island Hospital, Providence, Rhode Island., Dubielecka-Szczerba P; The Warren Alpert Medical School of Brown University, Providence, Rhode Island; Department of Hematology & Oncology, Rhode Island Hospital, Providence, Rhode Island., Del Monte F; Medical University of South Carolina, Charleston, South Carolina., Nerbonne J; Department of Developmental Biology, Medical School of Washington University, St. Louis, Missouri., Uydes-Dogan BS; Department of Pharmacology, Faculty of Pharmacy, Istanbul University, Istanbul, Türkiye, and., Roder K; The Warren Alpert Medical School of Brown University, Providence, Rhode Island; Cardiovascular Research Center, Rhode Island Hospital, Providence, Rhode Island., Choi BR; The Warren Alpert Medical School of Brown University, Providence, Rhode Island; Cardiovascular Research Center, Rhode Island Hospital, Providence, Rhode Island., Van Wagoner DR; Department of Heart, Blood and Kidney Research, Cleveland Clinic, Cleveland, Ohio., Sedivy JM; Department of Molecular Biology, Cell Biology and Biochemistry, Brown University, Providence, Rhode Island., Koren G; The Warren Alpert Medical School of Brown University, Providence, Rhode Island; Cardiovascular Research Center, Rhode Island Hospital, Providence, Rhode Island. Electronic address: gideon_koren@brown.edu.
Source: Heart rhythm [Heart Rhythm] 2026 Apr; Vol. 23 (4), pp. e675-e691. Date of Electronic Publication: 2026 Jan 07.
Publication Type: Journal Article
Journal Info: Publisher: Elsevier Country of Publication: United States NLM ID: 101200317 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1556-3871 (Electronic) Linking ISSN: 15475271 NLM ISO Abbreviation: Heart Rhythm Subsets: MEDLINE
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  Data: Senolytic reduction of senescent cells mitigates atrial arrhythmia vulnerability in aging rabbits.
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  Data: <searchLink fieldCode="AU" term="%22Sengun+E%22">Sengun E</searchLink>; The Warren Alpert Medical School of Brown University, Providence, Rhode Island; Cardiovascular Research Center, Rhode Island Hospital, Providence, Rhode Island; Department of Pharmacology, Institute of Graduate Studies in Health Sciences, Istanbul University, Istanbul, Türkiye.<br /><searchLink fieldCode="AU" term="%22Zhou+L%22">Zhou L</searchLink>; The Warren Alpert Medical School of Brown University, Providence, Rhode Island; Cardiovascular Research Center, Rhode Island Hospital, Providence, Rhode Island.<br /><searchLink fieldCode="AU" term="%22Kelsey+M%22">Kelsey M</searchLink>; Department of Molecular Biology, Cell Biology and Biochemistry, Brown University, Providence, Rhode Island.<br /><searchLink fieldCode="AU" term="%22Turan+NN%22">Turan NN</searchLink>; The Warren Alpert Medical School of Brown University, Providence, Rhode Island; Cardiovascular Research Center, Rhode Island Hospital, Providence, Rhode Island; School of Nursing and Health Sciences, Providence College, Providence, Rhode Island.<br /><searchLink fieldCode="AU" term="%22Lu+Y%22">Lu Y</searchLink>; Cardiovascular Research Center, Rhode Island Hospital, Providence, Rhode Island.<br /><searchLink fieldCode="AU" term="%22Kabakov+AY%22">Kabakov AY</searchLink>; The Warren Alpert Medical School of Brown University, Providence, Rhode Island; Cardiovascular Research Center, Rhode Island Hospital, Providence, Rhode Island.<br /><searchLink fieldCode="AU" term="%22Bronk+P%22">Bronk P</searchLink>; The Warren Alpert Medical School of Brown University, Providence, Rhode Island; Cardiovascular Research Center, Rhode Island Hospital, Providence, Rhode Island.<br /><searchLink fieldCode="AU" term="%22Mi+E%22">Mi E</searchLink>; The Warren Alpert Medical School of Brown University, Providence, Rhode Island; Cardiovascular Research Center, Rhode Island Hospital, Providence, Rhode Island.<br /><searchLink fieldCode="AU" term="%22Kim+TY%22">Kim TY</searchLink>; The Warren Alpert Medical School of Brown University, Providence, Rhode Island; Cardiovascular Research Center, Rhode Island Hospital, Providence, Rhode Island.<br /><searchLink fieldCode="AU" term="%22Vijayakumar+S%22">Vijayakumar S</searchLink>; The Warren Alpert Medical School of Brown University, Providence, Rhode Island; Cardiovascular Research Center, Rhode Island Hospital, Providence, Rhode Island.<br /><searchLink fieldCode="AU" term="%22Price+D%22">Price D</searchLink>; The Warren Alpert Medical School of Brown University, Providence, Rhode Island; Cardiovascular Research Center, Rhode Island Hospital, Providence, Rhode Island.<br /><searchLink fieldCode="AU" term="%22Nussbaum+SS%22">Nussbaum SS</searchLink>; The Warren Alpert Medical School of Brown University, Providence, Rhode Island; Cardiovascular Research Center, Rhode Island Hospital, Providence, Rhode Island.<br /><searchLink fieldCode="AU" term="%22Song+C%22">Song C</searchLink>; The Warren Alpert Medical School of Brown University, Providence, Rhode Island; Cardiovascular Research Center, Rhode Island Hospital, Providence, Rhode Island.<br /><searchLink fieldCode="AU" term="%22Feng+J%22">Feng J</searchLink>; The Warren Alpert Medical School of Brown University, Providence, Rhode Island; Cardiovascular Research Center, Rhode Island Hospital, Providence, Rhode Island.<br /><searchLink fieldCode="AU" term="%22Sellke+FW%22">Sellke FW</searchLink>; The Warren Alpert Medical School of Brown University, Providence, Rhode Island; Cardiovascular Research Center, Rhode Island Hospital, Providence, Rhode Island.<br /><searchLink fieldCode="AU" term="%22Dubielecka-Szczerba+P%22">Dubielecka-Szczerba P</searchLink>; The Warren Alpert Medical School of Brown University, Providence, Rhode Island; Department of Hematology & Oncology, Rhode Island Hospital, Providence, Rhode Island.<br /><searchLink fieldCode="AU" term="%22Del+Monte+F%22">Del Monte F</searchLink>; Medical University of South Carolina, Charleston, South Carolina.<br /><searchLink fieldCode="AU" term="%22Nerbonne+J%22">Nerbonne J</searchLink>; Department of Developmental Biology, Medical School of Washington University, St. Louis, Missouri.<br /><searchLink fieldCode="AU" term="%22Uydes-Dogan+BS%22">Uydes-Dogan BS</searchLink>; Department of Pharmacology, Faculty of Pharmacy, Istanbul University, Istanbul, Türkiye, and.<br /><searchLink fieldCode="AU" term="%22Roder+K%22">Roder K</searchLink>; The Warren Alpert Medical School of Brown University, Providence, Rhode Island; Cardiovascular Research Center, Rhode Island Hospital, Providence, Rhode Island.<br /><searchLink fieldCode="AU" term="%22Choi+BR%22">Choi BR</searchLink>; The Warren Alpert Medical School of Brown University, Providence, Rhode Island; Cardiovascular Research Center, Rhode Island Hospital, Providence, Rhode Island.<br /><searchLink fieldCode="AU" term="%22Van+Wagoner+DR%22">Van Wagoner DR</searchLink>; Department of Heart, Blood and Kidney Research, Cleveland Clinic, Cleveland, Ohio.<br /><searchLink fieldCode="AU" term="%22Sedivy+JM%22">Sedivy JM</searchLink>; Department of Molecular Biology, Cell Biology and Biochemistry, Brown University, Providence, Rhode Island.<br /><searchLink fieldCode="AU" term="%22Koren+G%22">Koren G</searchLink>; The Warren Alpert Medical School of Brown University, Providence, Rhode Island; Cardiovascular Research Center, Rhode Island Hospital, Providence, Rhode Island. Electronic address: gideon_koren@brown.edu.
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  Data: <searchLink fieldCode="JN" term="%22101200317%22">Heart rhythm</searchLink> [Heart Rhythm] 2026 Apr; Vol. 23 (4), pp. e675-e691. <i>Date of Electronic Publication: </i>2026 Jan 07.
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  Data: <i>Publisher: </i><searchLink fieldCode="PB" term="%22Elsevier%22">Elsevier </searchLink><i>Country of Publication: </i>United States <i>NLM ID: </i>101200317 <i>Publication Model: </i>Print-Electronic <i>Cited Medium: </i>Internet <i>ISSN: </i>1556-3871 (Electronic) <i>Linking ISSN: </i><searchLink fieldCode="IS" term="%2215475271%22">15475271 </searchLink><i>NLM ISO Abbreviation: </i>Heart Rhythm <i>Subsets: </i>MEDLINE
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        Value: 10.1016/j.hrthm.2026.01.007
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