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First human whole-body biodistribution and dosimetry analysis of [18F]LW223, a novel TSPO PET radiotracer.

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Title: First human whole-body biodistribution and dosimetry analysis of [18F]LW223, a novel TSPO PET radiotracer.
Authors: Khaing PH; Institute for Neuroscience and Cardiovascular Research, University of Edinburgh, Edinburgh, UK., MacAskill MG; Institute for Neuroscience and Cardiovascular Research, University of Edinburgh, Edinburgh, UK.; Edinburgh Imaging, University of Edinburgh, Edinburgh, UK., Xiao J; Department of Nuclear Medicine & PET Center, Huashan Hospital, Fudan University, Shanghai, China., Liu S; XingImaging LLC, New Haven, CT, USA., Gu Z; XingImaging LLC, New Haven, CT, USA., Sun X; XingImaging LLC, New Haven, CT, USA., Xu T; XingImaging LLC, New Haven, CT, USA., Koglin N; Life Molecular Imaging GmbH, Berlin, Germany., Stephens AW; Life Molecular Imaging GmbH, Berlin, Germany., Newby DE; Institute for Neuroscience and Cardiovascular Research, University of Edinburgh, Edinburgh, UK.; Edinburgh Imaging, University of Edinburgh, Edinburgh, UK., Guan Y; Department of Nuclear Medicine & PET Center, Huashan Hospital, Fudan University, Shanghai, China., McErlain H; School of Chemistry, University of Glasgow, Glasgow, UK., Sutherland A; School of Chemistry, University of Glasgow, Glasgow, UK., Tamagnan GD; XingImaging LLC, New Haven, CT, USA., Xie F; Department of Nuclear Medicine & PET Center, Huashan Hospital, Fudan University, Shanghai, China. fangxie@fudan.edu.cn., Tavares AAS; Institute for Neuroscience and Cardiovascular Research, University of Edinburgh, Edinburgh, UK. adriana.tavares@ed.ac.uk.; Edinburgh Imaging, University of Edinburgh, Edinburgh, UK. adriana.tavares@ed.ac.uk.; Institute for Neuroscience and Cardiovascular Research, Queen's Medical Research Institute, 47 Little France Crescent, Edinburgh, EH16 4TJ, UK. adriana.tavares@ed.ac.uk.
Source: European journal of nuclear medicine and molecular imaging [Eur J Nucl Med Mol Imaging] 2026 May; Vol. 53 (6), pp. 3951-3959. Date of Electronic Publication: 2026 Jan 10.
Publication Type: Journal Article
Journal Info: Publisher: Springer-Verlag Berlin Country of Publication: Germany NLM ID: 101140988 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1619-7089 (Electronic) Linking ISSN: 16197070 NLM ISO Abbreviation: Eur J Nucl Med Mol Imaging Subsets: MEDLINE
Database: MEDLINE Ultimate
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  Data: First human whole-body biodistribution and dosimetry analysis of [<superscript>18</superscript>F]LW223, a novel TSPO PET radiotracer.
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              Text: 2026 May
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