The computationally designed TRI2-2 miniprotein inhibitor protects against multiple SARS-CoV-2 Omicron variants.
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| Title: | The computationally designed TRI2-2 miniprotein inhibitor protects against multiple SARS-CoV-2 Omicron variants. |
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| Authors: | Lee J; Department of Biochemistry, University of Washington, Seattle, WA, USA., Case JB; Department of Medicine, Washington University School of Medicine, St. Louis, MO, USA., Park YJ; Department of Biochemistry, University of Washington, Seattle, WA, USA.; Howard Hughes Medical Institute, University of Washington, Seattle, WA, USA., Ravichandran R; Department of Biochemistry, University of Washington, Seattle, WA, USA.; Institute for Protein Design, University of Washington, Seattle, WA, USA., Asarnow D; Department of Biochemistry, University of Washington, Seattle, WA, USA., Tortorici MA; Department of Biochemistry, University of Washington, Seattle, WA, USA., Brown JT; Department of Biochemistry, University of Washington, Seattle, WA, USA., Sanapala S; Department of Medicine, Washington University School of Medicine, St. Louis, MO, USA., Carter L; Department of Biochemistry, University of Washington, Seattle, WA, USA.; Institute for Protein Design, University of Washington, Seattle, WA, USA., Baker D; Department of Biochemistry, University of Washington, Seattle, WA, USA.; Howard Hughes Medical Institute, University of Washington, Seattle, WA, USA.; Institute for Protein Design, University of Washington, Seattle, WA, USA., Diamond MS; Department of Medicine, Washington University School of Medicine, St. Louis, MO, USA. mdiamond@wustl.edu.; Department of Molecular Microbiology, Washington University School of Medicine, St. Louis, MO, USA. mdiamond@wustl.edu.; Department of Pathology and Immunology, Washington University School of Medicine, St. Louis, MO, USA. mdiamond@wustl.edu.; Andrew M. and Jane M. Bursky Center for Human Immunology and Immunotherapy Programs, Washington University School of Medicine, St. Louis, MO, USA. mdiamond@wustl.edu., Veesler D; Department of Biochemistry, University of Washington, Seattle, WA, USA. dveesler@uw.edu.; Howard Hughes Medical Institute, University of Washington, Seattle, WA, USA. dveesler@uw.edu. |
| Source: | Communications biology [Commun Biol] 2026 Jan 10; Vol. 9 (1), pp. 224. Date of Electronic Publication: 2026 Jan 10. |
| Publication Type: | Journal Article |
| Journal Info: | Publisher: Nature Publishing Group UK Country of Publication: England NLM ID: 101719179 Publication Model: Electronic Cited Medium: Internet ISSN: 2399-3642 (Electronic) Linking ISSN: 23993642 NLM ISO Abbreviation: Commun Biol Subsets: MEDLINE |
| Database: | MEDLINE Ultimate |
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