MOTS-c improves intrinsic muscle mitochondrial bioenergetic health and efficiency in a PGC-1α/AMPK-dependent manner.

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Title: MOTS-c improves intrinsic muscle mitochondrial bioenergetic health and efficiency in a PGC-1α/AMPK-dependent manner.
Authors: Gudiksen A; Section for Cell Biology and Physiology, Department of Biology, University of Copenhagen, Copenhagen, Denmark. Electronic address: anders.gudiksen@bio.ku.dk., Hansen CC; The August Krogh Section for Human and Molecular Physiology, Department of Nutrition, Exercise and Sports, University of Copenhagen, Copenhagen, Denmark., van der Stede T; The August Krogh Section for Human and Molecular Physiology, Department of Nutrition, Exercise and Sports, University of Copenhagen, Copenhagen, Denmark; Department of Movement and Sports Sciences, Ghent University, Ghent, Belgium., Daugaard AH; Section for Cell Biology and Physiology, Department of Biology, University of Copenhagen, Copenhagen, Denmark., Schmidt JH; Section for Cell Biology and Physiology, Department of Biology, University of Copenhagen, Copenhagen, Denmark., Ringholm S; Section for Cell Biology and Physiology, Department of Biology, University of Copenhagen, Copenhagen, Denmark., Merimi M; Section for Cell Biology and Physiology, Department of Biology, University of Copenhagen, Copenhagen, Denmark., Al-Obaidi FR; Section for Cell Biology and Physiology, Department of Biology, University of Copenhagen, Copenhagen, Denmark., Kristoffersen AT; Section for Cell Biology and Physiology, Department of Biology, University of Copenhagen, Copenhagen, Denmark., Zole E; Section for Ecology and Evolution, Department of Biology, University of Copenhagen, Denmark., Regenberg B; Section for Ecology and Evolution, Department of Biology, University of Copenhagen, Denmark., Kjøbsted R; The August Krogh Section for Human and Molecular Physiology, Department of Nutrition, Exercise and Sports, University of Copenhagen, Copenhagen, Denmark., Wojtaszewski J; The August Krogh Section for Human and Molecular Physiology, Department of Nutrition, Exercise and Sports, University of Copenhagen, Copenhagen, Denmark., Hellsten Y; The August Krogh Section for Human and Molecular Physiology, Department of Nutrition, Exercise and Sports, University of Copenhagen, Copenhagen, Denmark., Pilegaard H; Section for Cell Biology and Physiology, Department of Biology, University of Copenhagen, Copenhagen, Denmark. Electronic address: hpilegaard@bio.ku.dk.
Source: Free radical biology & medicine [Free Radic Biol Med] 2026 Mar 16; Vol. 246, pp. 682-696. Date of Electronic Publication: 2026 Jan 09.
Publication Type: Journal Article
Journal Info: Publisher: Elsevier Science Country of Publication: United States NLM ID: 8709159 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1873-4596 (Electronic) Linking ISSN: 08915849 NLM ISO Abbreviation: Free Radic Biol Med Subsets: MEDLINE
Database: MEDLINE Ultimate
Description
ISSN:1873-4596
DOI:10.1016/j.freeradbiomed.2026.01.002