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A compartmentalized inflammatory landscape and macrophage plasticity regulate Tet2+/--mediated clonal hematopoiesis.

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Title: A compartmentalized inflammatory landscape and macrophage plasticity regulate Tet2+/--mediated clonal hematopoiesis.
Authors: Lee K; Department of Biomedical Engineering, University of Rochester, Rochester, NY.; Department of Orthopaedics, Center for Musculoskeletal Research, University of Rochester Medical Center, Rochester, NY., Hong CL; Department of Orthopaedics, Center for Musculoskeletal Research, University of Rochester Medical Center, Rochester, NY.; Department of Physiology and Pharmacology, University of Rochester Medical Center, Rochester, NY., Dissanayake W; Department of Orthopaedics, Center for Musculoskeletal Research, University of Rochester Medical Center, Rochester, NY.; Department of Biology, University of Rochester, Rochester, NY., Kulzhanova G; Department of Biomedical Engineering, University of Rochester, Rochester, NY.; Department of Orthopaedics, Center for Musculoskeletal Research, University of Rochester Medical Center, Rochester, NY., Pfeffer AN; Department of Physiology and Pharmacology, University of Rochester Medical Center, Rochester, NY., Li H; Department of Orthopaedics, Center for Musculoskeletal Research, University of Rochester Medical Center, Rochester, NY., Sivakumar S; Department of Biology, University of Rochester, Rochester, NY., Yin Z; Institute of Optics, University of Rochester, Rochester, NY., Quarato ER; Department of Toxicology, University of Rochester Medical Center, Rochester, NY.; Wilmot Cancer Institute, University of Rochester Medical Center, Rochester, NY., Benoodt L; Genomics Research Center, University of Rochester Medical Center, Rochester, NY., Bajaj J; Wilmot Cancer Institute, University of Rochester Medical Center, Rochester, NY.; Department of Biomedical Genetics, University of Rochester Medical Center, Rochester, NY., Cao C; Department of Orthopaedics, Center for Musculoskeletal Research, University of Rochester Medical Center, Rochester, NY.; Department of Physiology and Pharmacology, University of Rochester Medical Center, Rochester, NY., Wu CL; Department of Biomedical Engineering, University of Rochester, Rochester, NY.; Department of Orthopaedics, Center for Musculoskeletal Research, University of Rochester Medical Center, Rochester, NY., Calvi LM; Department of Orthopaedics, Center for Musculoskeletal Research, University of Rochester Medical Center, Rochester, NY.; Wilmot Cancer Institute, University of Rochester Medical Center, Rochester, NY.; Department of Medicine, University of Rochester Medical Center, Rochester, NY., Yeh SA; Department of Biomedical Engineering, University of Rochester, Rochester, NY.; Department of Orthopaedics, Center for Musculoskeletal Research, University of Rochester Medical Center, Rochester, NY.; Department of Physiology and Pharmacology, University of Rochester Medical Center, Rochester, NY.; Wilmot Cancer Institute, University of Rochester Medical Center, Rochester, NY.
Source: Blood [Blood] 2026 Apr 16; Vol. 147 (16), pp. 1828-1841.
Publication Type: Journal Article
Journal Info: Publisher: Elsevier Country of Publication: United States NLM ID: 7603509 Publication Model: Print Cited Medium: Internet ISSN: 1528-0020 (Electronic) Linking ISSN: 00064971 NLM ISO Abbreviation: Blood Subsets: MEDLINE
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  Data: A compartmentalized inflammatory landscape and macrophage plasticity regulate Tet2+/--mediated clonal hematopoiesis.
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  Data: <searchLink fieldCode="AU" term="%22Lee+K%22">Lee K</searchLink>; Department of Biomedical Engineering, University of Rochester, Rochester, NY.; Department of Orthopaedics, Center for Musculoskeletal Research, University of Rochester Medical Center, Rochester, NY.<br /><searchLink fieldCode="AU" term="%22Hong+CL%22">Hong CL</searchLink>; Department of Orthopaedics, Center for Musculoskeletal Research, University of Rochester Medical Center, Rochester, NY.; Department of Physiology and Pharmacology, University of Rochester Medical Center, Rochester, NY.<br /><searchLink fieldCode="AU" term="%22Dissanayake+W%22">Dissanayake W</searchLink>; Department of Orthopaedics, Center for Musculoskeletal Research, University of Rochester Medical Center, Rochester, NY.; Department of Biology, University of Rochester, Rochester, NY.<br /><searchLink fieldCode="AU" term="%22Kulzhanova+G%22">Kulzhanova G</searchLink>; Department of Biomedical Engineering, University of Rochester, Rochester, NY.; Department of Orthopaedics, Center for Musculoskeletal Research, University of Rochester Medical Center, Rochester, NY.<br /><searchLink fieldCode="AU" term="%22Pfeffer+AN%22">Pfeffer AN</searchLink>; Department of Physiology and Pharmacology, University of Rochester Medical Center, Rochester, NY.<br /><searchLink fieldCode="AU" term="%22Li+H%22">Li H</searchLink>; Department of Orthopaedics, Center for Musculoskeletal Research, University of Rochester Medical Center, Rochester, NY.<br /><searchLink fieldCode="AU" term="%22Sivakumar+S%22">Sivakumar S</searchLink>; Department of Biology, University of Rochester, Rochester, NY.<br /><searchLink fieldCode="AU" term="%22Yin+Z%22">Yin Z</searchLink>; Institute of Optics, University of Rochester, Rochester, NY.<br /><searchLink fieldCode="AU" term="%22Quarato+ER%22">Quarato ER</searchLink>; Department of Toxicology, University of Rochester Medical Center, Rochester, NY.; Wilmot Cancer Institute, University of Rochester Medical Center, Rochester, NY.<br /><searchLink fieldCode="AU" term="%22Benoodt+L%22">Benoodt L</searchLink>; Genomics Research Center, University of Rochester Medical Center, Rochester, NY.<br /><searchLink fieldCode="AU" term="%22Bajaj+J%22">Bajaj J</searchLink>; Wilmot Cancer Institute, University of Rochester Medical Center, Rochester, NY.; Department of Biomedical Genetics, University of Rochester Medical Center, Rochester, NY.<br /><searchLink fieldCode="AU" term="%22Cao+C%22">Cao C</searchLink>; Department of Orthopaedics, Center for Musculoskeletal Research, University of Rochester Medical Center, Rochester, NY.; Department of Physiology and Pharmacology, University of Rochester Medical Center, Rochester, NY.<br /><searchLink fieldCode="AU" term="%22Wu+CL%22">Wu CL</searchLink>; Department of Biomedical Engineering, University of Rochester, Rochester, NY.; Department of Orthopaedics, Center for Musculoskeletal Research, University of Rochester Medical Center, Rochester, NY.<br /><searchLink fieldCode="AU" term="%22Calvi+LM%22">Calvi LM</searchLink>; Department of Orthopaedics, Center for Musculoskeletal Research, University of Rochester Medical Center, Rochester, NY.; Wilmot Cancer Institute, University of Rochester Medical Center, Rochester, NY.; Department of Medicine, University of Rochester Medical Center, Rochester, NY.<br /><searchLink fieldCode="AU" term="%22Yeh+SA%22">Yeh SA</searchLink>; Department of Biomedical Engineering, University of Rochester, Rochester, NY.; Department of Orthopaedics, Center for Musculoskeletal Research, University of Rochester Medical Center, Rochester, NY.; Department of Physiology and Pharmacology, University of Rochester Medical Center, Rochester, NY.; Wilmot Cancer Institute, University of Rochester Medical Center, Rochester, NY.
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        Value: 10.1182/blood.2024028031
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              Text: 2026 Apr 16
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