ZIP8 loss impairs macrophage-mediated phagolysosomal removal of bacteria and is overcome by butyrate supplementation.

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Title: ZIP8 loss impairs macrophage-mediated phagolysosomal removal of bacteria and is overcome by butyrate supplementation.
Authors: Smith DR; Department of Pharmacy Practice and Science, College of Pharmacy, Omaha, NE, USA.; Department of Internal Medicine-Pulmonary Division, College of Medicine, Omaha, NE, USA., Haq S; Department of Pharmacy Practice and Science, College of Pharmacy, Omaha, NE, USA.; Department of Internal Medicine-Pulmonary Division, College of Medicine, Omaha, NE, USA., Niu M; Department of Neurological Sciences, Omaha, NE, USA., Malla S; University of Nebraska Medical Center, Omaha, NE, USA.; College of Engineering, University of Nebraska, Lincoln, NE, USA., Saha R; University of Nebraska Medical Center, Omaha, NE, USA.; College of Engineering, University of Nebraska, Lincoln, NE, USA., Peer A; Department of Internal Medicine-Pulmonary Division, College of Medicine, Omaha, NE, USA., Bianco P; Department of Pharmaceutical Science, Omaha, NE, USA., Romanova S; Department of Pharmaceutical Science, Omaha, NE, USA., Samuelson DR; Department of Internal Medicine-Pulmonary Division, College of Medicine, Omaha, NE, USA. derrick.samuelson@unmc.edu., Knoell DL; Department of Pharmacy Practice and Science, College of Pharmacy, Omaha, NE, USA. daren.knoell@unmc.edu.; Department of Internal Medicine-Pulmonary Division, College of Medicine, Omaha, NE, USA. daren.knoell@unmc.edu.
Source: Communications biology [Commun Biol] 2026 Jan 12; Vol. 9 (1), pp. 228. Date of Electronic Publication: 2026 Jan 12.
Publication Type: Journal Article
Journal Info: Publisher: Nature Publishing Group UK Country of Publication: England NLM ID: 101719179 Publication Model: Electronic Cited Medium: Internet ISSN: 2399-3642 (Electronic) Linking ISSN: 23993642 NLM ISO Abbreviation: Commun Biol Subsets: MEDLINE
Database: MEDLINE Ultimate
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ISSN:2399-3642
DOI:10.1038/s42003-025-09504-8