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Increased risk of type I errors for detecting heterogeneity of treatment effects in cluster-randomized trials using mixed-effect models.

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Bibliographic Details
Title: Increased risk of type I errors for detecting heterogeneity of treatment effects in cluster-randomized trials using mixed-effect models.
Authors: Hyun N; Kaiser Permanente Washington Health Research Institute, 1730 Minor Ave., Ste 1360, Seattle, WA, 98101, USA. noorie.hyun@kp.org.; Department of Biostatistics, School of Public Health, University of Washington, Seattle, Washington, USA. noorie.hyun@kp.org., Idu AE; Kaiser Permanente Washington Health Research Institute, 1730 Minor Ave., Ste 1360, Seattle, WA, 98101, USA., Cook AJ; Kaiser Permanente Washington Health Research Institute, 1730 Minor Ave., Ste 1360, Seattle, WA, 98101, USA.; Department of Biostatistics, School of Public Health, University of Washington, Seattle, Washington, USA., Bobb JF; Kaiser Permanente Washington Health Research Institute, 1730 Minor Ave., Ste 1360, Seattle, WA, 98101, USA.; Department of Biostatistics, School of Public Health, University of Washington, Seattle, Washington, USA.
Source: BMC medical research methodology [BMC Med Res Methodol] 2026 Jan 12; Vol. 26 (1), pp. 30. Date of Electronic Publication: 2026 Jan 12.
Publication Type: Journal Article
Journal Info: Publisher: BioMed Central Country of Publication: England NLM ID: 100968545 Publication Model: Electronic Cited Medium: Internet ISSN: 1471-2288 (Electronic) Linking ISSN: 14712288 NLM ISO Abbreviation: BMC Med Res Methodol Subsets: MEDLINE
Database: MEDLINE Ultimate
Description
ISSN:1471-2288
DOI:10.1186/s12874-025-02744-6