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Increased risk of type I errors for detecting heterogeneity of treatment effects in cluster-randomized trials using mixed-effect models.

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Title: Increased risk of type I errors for detecting heterogeneity of treatment effects in cluster-randomized trials using mixed-effect models.
Authors: Hyun N; Kaiser Permanente Washington Health Research Institute, 1730 Minor Ave., Ste 1360, Seattle, WA, 98101, USA. noorie.hyun@kp.org.; Department of Biostatistics, School of Public Health, University of Washington, Seattle, Washington, USA. noorie.hyun@kp.org., Idu AE; Kaiser Permanente Washington Health Research Institute, 1730 Minor Ave., Ste 1360, Seattle, WA, 98101, USA., Cook AJ; Kaiser Permanente Washington Health Research Institute, 1730 Minor Ave., Ste 1360, Seattle, WA, 98101, USA.; Department of Biostatistics, School of Public Health, University of Washington, Seattle, Washington, USA., Bobb JF; Kaiser Permanente Washington Health Research Institute, 1730 Minor Ave., Ste 1360, Seattle, WA, 98101, USA.; Department of Biostatistics, School of Public Health, University of Washington, Seattle, Washington, USA.
Source: BMC medical research methodology [BMC Med Res Methodol] 2026 Jan 12; Vol. 26 (1), pp. 30. Date of Electronic Publication: 2026 Jan 12.
Publication Type: Journal Article
Journal Info: Publisher: BioMed Central Country of Publication: England NLM ID: 100968545 Publication Model: Electronic Cited Medium: Internet ISSN: 1471-2288 (Electronic) Linking ISSN: 14712288 NLM ISO Abbreviation: BMC Med Res Methodol Subsets: MEDLINE
Database: MEDLINE Ultimate
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  Data: <searchLink fieldCode="AU" term="%22Hyun+N%22">Hyun N</searchLink>; Kaiser Permanente Washington Health Research Institute, 1730 Minor Ave., Ste 1360, Seattle, WA, 98101, USA. noorie.hyun@kp.org.; Department of Biostatistics, School of Public Health, University of Washington, Seattle, Washington, USA. noorie.hyun@kp.org.<br /><searchLink fieldCode="AU" term="%22Idu+AE%22">Idu AE</searchLink>; Kaiser Permanente Washington Health Research Institute, 1730 Minor Ave., Ste 1360, Seattle, WA, 98101, USA.<br /><searchLink fieldCode="AU" term="%22Cook+AJ%22">Cook AJ</searchLink>; Kaiser Permanente Washington Health Research Institute, 1730 Minor Ave., Ste 1360, Seattle, WA, 98101, USA.; Department of Biostatistics, School of Public Health, University of Washington, Seattle, Washington, USA.<br /><searchLink fieldCode="AU" term="%22Bobb+JF%22">Bobb JF</searchLink>; Kaiser Permanente Washington Health Research Institute, 1730 Minor Ave., Ste 1360, Seattle, WA, 98101, USA.; Department of Biostatistics, School of Public Health, University of Washington, Seattle, Washington, USA.
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  Data: <searchLink fieldCode="JN" term="%22100968545%22">BMC medical research methodology</searchLink> [BMC Med Res Methodol] 2026 Jan 12; Vol. 26 (1), pp. 30. <i>Date of Electronic Publication: </i>2026 Jan 12.
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  Data: <i>Publisher: </i><searchLink fieldCode="PB" term="%22BioMed+Central%22">BioMed Central </searchLink><i>Country of Publication: </i>England <i>NLM ID: </i>100968545 <i>Publication Model: </i>Electronic <i>Cited Medium: </i>Internet <i>ISSN: </i>1471-2288 (Electronic) <i>Linking ISSN: </i><searchLink fieldCode="IS" term="%2214712288%22">14712288 </searchLink><i>NLM ISO Abbreviation: </i>BMC Med Res Methodol <i>Subsets: </i>MEDLINE
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        Value: 10.1186/s12874-025-02744-6
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              Text: 2026 Jan 12
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