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Hepatic loss of AATF attenuates MASH by suppressing AKT-mTORC1 signaling and reprogramming lipid metabolism.

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Title: Hepatic loss of AATF attenuates MASH by suppressing AKT-mTORC1 signaling and reprogramming lipid metabolism.
Authors: Srinivas AN; Department of Biochemistry, CEMR, JSS Medical College, JSS Academy of Higher Education and Research, Mysuru, Karnataka, India., Suresh D; Department of Biochemistry, CEMR, JSS Medical College, JSS Academy of Higher Education and Research, Mysuru, Karnataka, India., Anirvan P; Department of Translational Research, Kalinga Gastroenterology Foundation, Cuttack, Odisha, India., Moorthy M; TheraCUES Innovations Pvt. Ltd, Bangalore, India., Ramaswamy G; TheraCUES Innovations Pvt. Ltd, Bangalore, India., Nataraj SM; Department of Biochemistry, CEMR, JSS Medical College, JSS Academy of Higher Education and Research, Mysuru, Karnataka, India., Santhekadur PK; Department of Biochemistry, CEMR, JSS Medical College, JSS Academy of Higher Education and Research, Mysuru, Karnataka, India., Suvarna D; Department of Gastroenterology, JSS Medical College and Hospital, JSS Academy of Higher Education and Research, Mysuru, Karnataka, 570015, India., Singh SP; Department of Translational Research, Kalinga Gastroenterology Foundation, Cuttack, Odisha, India., Kumar DP; Department of Biochemistry, CEMR, JSS Medical College, JSS Academy of Higher Education and Research, Mysuru, Karnataka, India. divyapk243@gmail.com.
Source: Molecular medicine (Cambridge, Mass.) [Mol Med] 2026 Jan 13; Vol. 32 (1), pp. 19. Date of Electronic Publication: 2026 Jan 13.
Publication Type: Journal Article
Journal Info: Publisher: BioMed Central Country of Publication: England NLM ID: 9501023 Publication Model: Electronic Cited Medium: Internet ISSN: 1528-3658 (Electronic) Linking ISSN: 10761551 NLM ISO Abbreviation: Mol Med Subsets: MEDLINE
Database: MEDLINE Ultimate
Description
ISSN:1528-3658
DOI:10.1186/s10020-025-01417-w