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A Series of Pyrazolo-Quinazoline Amines Inhibits the Cytochrome bd Oxidase in Mycobacterium tuberculosis.

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Title: A Series of Pyrazolo-Quinazoline Amines Inhibits the Cytochrome bd Oxidase in Mycobacterium tuberculosis.
Authors: Singh S; Nanyang Technological University, Lee Kong Chian School of Medicine, Singapore 636921, Singapore., Ng PS; Experimental Drug Development Centre, Agency for Science, Technology and Research, Singapore 138670, Singapore., Lakshmanan U; Experimental Drug Development Centre, Agency for Science, Technology and Research, Singapore 138670, Singapore., Mathiyazakan V; Nanyang Technological University, Lee Kong Chian School of Medicine, Singapore 636921, Singapore.; School of Biological Sciences, Nanyang Technological University, Singapore 637551, Singapore., Wiggins T; Department of Microbiology and Immunology, Albert Einstein College of Medicine, Bronx, New York 10461, United States., Lee BS; Nanyang Technological University, Lee Kong Chian School of Medicine, Singapore 636921, Singapore.; Department of Microbiology and Immunology, Albert Einstein College of Medicine, Bronx, New York 10461, United States., Ang SH; Experimental Drug Development Centre, Agency for Science, Technology and Research, Singapore 138670, Singapore., Lin Sim SW; Experimental Drug Development Centre, Agency for Science, Technology and Research, Singapore 138670, Singapore., Santos MD; Antimicrobial Resistance Interdisciplinary Research Group, Singapore-MIT Alliance for Research and Technology Centre, Singapore 138602, Singapore., Moraski G; Department of Chemistry and Biochemistry, Montana State University, 103 Chemistry and Biochemistry, Bozeman, Montana 59717, United States., Miller M; Department of Chemistry and Biochemistry, University of Notre Dame, Notre Dame, Indiana 46556, United States., Berney M; Department of Microbiology and Immunology, Albert Einstein College of Medicine, Bronx, New York 10461, United States.; Division of Pathogen Biology, Epidemiology, Biostatistics and Prevention Institute, University of Zurich, Hirschengraben 84, Zurich 8001, Switzerland., Grüber G; School of Biological Sciences, Nanyang Technological University, Singapore 637551, Singapore., Pethe K; Nanyang Technological University, Lee Kong Chian School of Medicine, Singapore 636921, Singapore.; Singapore Centre for Environmental Life Sciences Engineering, Nanyang Technological University, Singapore 637551, Singapore.; National Centre for Infectious Diseases, Singapore 308442, Singapore.; ASTAR Infectious Diseases Laboratories (ASTAR ID Laboratories), Agency for Science, Technology and Research (ASTAR), Singapore 138648, Singapore.
Source: Journal of medicinal chemistry [J Med Chem] 2026 Feb 12; Vol. 69 (3), pp. 2130-2144. Date of Electronic Publication: 2026 Jan 13.
Publication Type: Journal Article
Journal Info: Publisher: American Chemical Society Country of Publication: United States NLM ID: 9716531 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1520-4804 (Electronic) Linking ISSN: 00222623 NLM ISO Abbreviation: J Med Chem Subsets: MEDLINE
Database: MEDLINE Ultimate
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  Data: A Series of Pyrazolo-Quinazoline Amines Inhibits the Cytochrome bd Oxidase in Mycobacterium tuberculosis.
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        Value: 10.1021/acs.jmedchem.5c01616
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              Text: 2026 Feb 12
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