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Endothelial cell-released CD93 contributes to podocyte injury in idiopathic nephrotic syndrome.

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Title: Endothelial cell-released CD93 contributes to podocyte injury in idiopathic nephrotic syndrome.
Authors: Bauer C; Department of Pediatrics, Section of Pediatric Nephrology, Children's Hospital Colorado, Aurora, CO 80045, USA., Piani F; Department of Pediatrics, Section of Pediatric Nephrology, Children's Hospital Colorado, Aurora, CO 80045, USA.; Department of Medicine, IRCCS Asiendo Ospedaliero-Universitaria di Bologna, Bologna 40138, Italy., Troost J; Michigan Institute for Clinical and Health Research, University of Michigan, Ann Arbor, MI 48109, USA., Da Sacco S; GOFARR Laboratory for Organ Regenerative Research and Cell Therapeutics in Urology, Saban Research Institute, Division of Urology, Children's Hospital Los Angeles (CHLA), Los Angeles, CA 90027, USA., Rojas-Sanchez G; BloodWorks Northwest, Seattle, WA 98104, USA.; Department of Pediatrics, University of Washington, Seattle, WA 98105, USA., Davizon-Castillo P; BloodWorks Northwest, Seattle, WA 98104, USA.; Department of Pediatrics, University of Washington, Seattle, WA 98105, USA., Perin L; GOFARR Laboratory for Organ Regenerative Research and Cell Therapeutics in Urology, Saban Research Institute, Division of Urology, Children's Hospital Los Angeles (CHLA), Los Angeles, CA 90027, USA., Daehn I; Department of Medicine, Division of Nephrology, Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA., Islam MI; Kidney and Urinary Tract Center, Abigail Wexner Research Institute at Nationwide Children's Hospital, Columbus, OH 43205, USA., Fetsko A; Kidney and Urinary Tract Center, Abigail Wexner Research Institute at Nationwide Children's Hospital, Columbus, OH 43205, USA., Carrera-Muñoz C; Department of Pediatrics, Section of Pediatric Nephrology, Children's Hospital Colorado, Aurora, CO 80045, USA., Rovin B; Division of Nephrology, Ohio State University, Columbus, OH 43210, USA., Zhang XL; Division of Nephrology, Ohio State University, Columbus, OH 43210, USA., Banks M; Rocky Mountain Pediatric Kidney Center, Rocky Mountain Hospital for Children, Denver, CO 80205, USA., de Lucas-Collantes C; Department of Pediatric Nephrology, Hospital Niño Jesus, Madrid 28009, Spain., Ordóñez-Álvarez FA; Department of Pediatric Nephrology, Hospital Universitario Central de Asturias, Oviedo 33011, Spain., Aparicio-López C; Department of Pediatric Nephrology, Hospital Niño Jesus, Madrid 28009, Spain., Lanaspa MA; Division of Endocrinology, Metabolism and Diabetes, University of Colorado Anschutz Medical Campus, Aurora, CO 80045, USA., Andres-Hernando A; Division of Endocrinology, Metabolism and Diabetes, University of Colorado Anschutz Medical Campus, Aurora, CO 80045, USA., Segarra A; Department of Nephrology, Hospital Universitario Arnau de Vilanova, Lleida 25198, Spain., Martinez C; Renal Physiopathology Group, Vall d'Hebron Research Institute (VHIR), Barcelona 08035, Spain., Bjornstad P; Division of Endocrinology, Metabolism, and Nutrition, University of Washington School of Medicine, Seattle, WA 98109, USA.; Department of Pediatrics, Section of Pediatric Endocrinology, Children's Hospital Colorado and University of Colorado Anschutz Medical Campus, Aurora, CO 80045, USA.; Department of Medicine, Division of Renal Diseases and Hypertension, University of Colorado Anschutz Medical Campus, Aurora, CO 80045, USA., Lucia MS; Department of Pathology, University of Colorado Anschutz Medical Campus, Aurora, CO 80045, USA., Schaefer F; Pediatric Nephrology Division, Heidelberg University Hospital, Heidelberg 69120, Germany., Yilmaz A; Istanbul Faculty of Medicine, Istanbul University, Istanbul 34093, Türkiye., Zurowska A; Department of Pediatric and Adolescent Nephrology, Medical University of Gdansk, Gdansk 80-210, Poland., Wang X; Kidney and Urinary Tract Center, Abigail Wexner Research Institute at Nationwide Children's Hospital, Columbus, OH 43205, USA., McCown PJ; Division of Nephrology, University of Michigan, Ann Arbor, MI 48109, USA., Eddy S; Division of Nephrology, University of Michigan, Ann Arbor, MI 48109, USA., Hartman J; Division of Nephrology, University of Michigan, Ann Arbor, MI 48109, USA., Mariani L; Division of Nephrology, University of Michigan, Ann Arbor, MI 48109, USA., Kretzler M; Division of Nephrology, University of Michigan, Ann Arbor, MI 48109, USA., Zhu Y; Department of Surgery, University of Colorado Anschutz Medical Campus, Aurora, CO 80045, USA., Bouts AHM; Department of Pediatric Nephrology, Emma Children's Hospital, Amsterdam University Medical Centers, University of Amsterdam, Amsterdam 1105, Netherlands., Levtchenko EN; Department of Pediatric Nephrology, Emma Children's Hospital, Amsterdam University Medical Centers, University of Amsterdam, Amsterdam 1105, Netherlands., Dougherty JA; Center for Clinical and Translational Research, Abigail Wexner Research Institute at Nationwide Children's Hospital, Columbus, OH 43205, USA., Smoyer WE; Center for Clinical and Translational Research, Abigail Wexner Research Institute at Nationwide Children's Hospital, Columbus, OH 43205, USA., Kerlin BA; Center for Clinical and Translational Research, Abigail Wexner Research Institute at Nationwide Children's Hospital, Columbus, OH 43205, USA., Kallash M; Division of Pediatric Nephrology, Nationwide Children's Hospital, Columbus, OH 43205, USA., Soranno DE; Department of Pediatrics, Section of Nephrology, Indiana University School of Medicine, Indianapolis, IN 46202, USA., Cabrera-Sevilla JE; Department of Pediatrics, Division of Pediatric Nephrology, Hospital Universitario Santa Lucia, Cartagena 30202, Spain., Gonzalez-Rodriguez JD; Department of Pediatrics, Division of Pediatric Nephrology, Hospital Universitario Santa Lucia, Cartagena 30202, Spain., Siegele BJ; Department of Pathology and Laboratory Medicine, Children's Hospital Colorado, Aurora, CO 80045, USA., Tsuji S; Department of Pediatrics, Kansai Medical University, Osaka 573-1191, Japan., Kaneko K; Department of Pediatrics, Kansai Medical University, Osaka 573-1191, Japan., Sethna CB; Division of Pediatric Nephrology, Cohen Children's Medical Center, New York, NY 11042, USA., Srivastava T; Pediatric Nephrology, Children's Mercy Hospital, Kansas City, MO 64108, USA., Bitzer M; Division of Nephrology, University of Michigan, Ann Arbor, MI 48109, USA., O'Connor CL; Division of Nephrology, University of Michigan, Ann Arbor, MI 48109, USA., Dimberg A; Department of Immunology, Genetics and Pathology, Science for Life Laboratory, Rudbeck Laboratory, Uppsala University, Uppsala 75185, Sweden., Zhao S; Department of Medicine, Division of Nephrology, Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA., Yu L; Department of Medicine, Division of Nephrology, Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA., Thurman JM; Department of Medicine, Division of Renal Diseases and Hypertension, University of Colorado Anschutz Medical Campus, Aurora, CO 80045, USA., Johnson RJ; Department of Medicine, Division of Renal Diseases and Hypertension, University of Colorado Anschutz Medical Campus, Aurora, CO 80045, USA., Cara-Fuentes G; Department of Pediatrics, Section of Pediatric Nephrology, Children's Hospital Colorado, Aurora, CO 80045, USA.; Kidney and Urinary Tract Center, Abigail Wexner Research Institute at Nationwide Children's Hospital, Columbus, OH 43205, USA.; Department of Medicine, Division of Renal Diseases and Hypertension, University of Colorado Anschutz Medical Campus, Aurora, CO 80045, USA.
Source: Science translational medicine [Sci Transl Med] 2026 Jan 14; Vol. 18 (832), pp. eadw2206. Date of Electronic Publication: 2026 Jan 14.
Publication Type: Journal Article
Journal Info: Publisher: American Association for the Advancement of Science Country of Publication: United States NLM ID: 101505086 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1946-6242 (Electronic) Linking ISSN: 19466234 NLM ISO Abbreviation: Sci Transl Med Subsets: MEDLINE
Database: MEDLINE Ultimate
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  Data: Endothelial cell-released CD93 contributes to podocyte injury in idiopathic nephrotic syndrome.
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  Data: <searchLink fieldCode="AU" term="%22Bauer+C%22">Bauer C</searchLink>; Department of Pediatrics, Section of Pediatric Nephrology, Children's Hospital Colorado, Aurora, CO 80045, USA.<br /><searchLink fieldCode="AU" term="%22Piani+F%22">Piani F</searchLink>; Department of Pediatrics, Section of Pediatric Nephrology, Children's Hospital Colorado, Aurora, CO 80045, USA.; Department of Medicine, IRCCS Asiendo Ospedaliero-Universitaria di Bologna, Bologna 40138, Italy.<br /><searchLink fieldCode="AU" term="%22Troost+J%22">Troost J</searchLink>; Michigan Institute for Clinical and Health Research, University of Michigan, Ann Arbor, MI 48109, USA.<br /><searchLink fieldCode="AU" term="%22Da+Sacco+S%22">Da Sacco S</searchLink>; GOFARR Laboratory for Organ Regenerative Research and Cell Therapeutics in Urology, Saban Research Institute, Division of Urology, Children's Hospital Los Angeles (CHLA), Los Angeles, CA 90027, USA.<br /><searchLink fieldCode="AU" term="%22Rojas-Sanchez+G%22">Rojas-Sanchez G</searchLink>; BloodWorks Northwest, Seattle, WA 98104, USA.; Department of Pediatrics, University of Washington, Seattle, WA 98105, USA.<br /><searchLink fieldCode="AU" term="%22Davizon-Castillo+P%22">Davizon-Castillo P</searchLink>; BloodWorks Northwest, Seattle, WA 98104, USA.; Department of Pediatrics, University of Washington, Seattle, WA 98105, USA.<br /><searchLink fieldCode="AU" term="%22Perin+L%22">Perin L</searchLink>; GOFARR Laboratory for Organ Regenerative Research and Cell Therapeutics in Urology, Saban Research Institute, Division of Urology, Children's Hospital Los Angeles (CHLA), Los Angeles, CA 90027, USA.<br /><searchLink fieldCode="AU" term="%22Daehn+I%22">Daehn I</searchLink>; Department of Medicine, Division of Nephrology, Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA.<br /><searchLink fieldCode="AU" term="%22Islam+MI%22">Islam MI</searchLink>; Kidney and Urinary Tract Center, Abigail Wexner Research Institute at Nationwide Children's Hospital, Columbus, OH 43205, USA.<br /><searchLink fieldCode="AU" term="%22Fetsko+A%22">Fetsko A</searchLink>; Kidney and Urinary Tract Center, Abigail Wexner Research Institute at Nationwide Children's Hospital, Columbus, OH 43205, USA.<br /><searchLink fieldCode="AU" term="%22Carrera-Muñoz+C%22">Carrera-Muñoz C</searchLink>; Department of Pediatrics, Section of Pediatric Nephrology, Children's Hospital Colorado, Aurora, CO 80045, USA.<br /><searchLink fieldCode="AU" term="%22Rovin+B%22">Rovin B</searchLink>; Division of Nephrology, Ohio State University, Columbus, OH 43210, USA.<br /><searchLink fieldCode="AU" term="%22Zhang+XL%22">Zhang XL</searchLink>; Division of Nephrology, Ohio State University, Columbus, OH 43210, USA.<br /><searchLink fieldCode="AU" term="%22Banks+M%22">Banks M</searchLink>; Rocky Mountain Pediatric Kidney Center, Rocky Mountain Hospital for Children, Denver, CO 80205, USA.<br /><searchLink fieldCode="AU" term="%22de+Lucas-Collantes+C%22">de Lucas-Collantes C</searchLink>; Department of Pediatric Nephrology, Hospital Niño Jesus, Madrid 28009, Spain.<br /><searchLink fieldCode="AU" term="%22Ordóñez-Álvarez+FA%22">Ordóñez-Álvarez FA</searchLink>; Department of Pediatric Nephrology, Hospital Universitario Central de Asturias, Oviedo 33011, Spain.<br /><searchLink fieldCode="AU" term="%22Aparicio-López+C%22">Aparicio-López C</searchLink>; Department of Pediatric Nephrology, Hospital Niño Jesus, Madrid 28009, Spain.<br /><searchLink fieldCode="AU" term="%22Lanaspa+MA%22">Lanaspa MA</searchLink>; Division of Endocrinology, Metabolism and Diabetes, University of Colorado Anschutz Medical Campus, Aurora, CO 80045, USA.<br /><searchLink fieldCode="AU" term="%22Andres-Hernando+A%22">Andres-Hernando A</searchLink>; Division of Endocrinology, Metabolism and Diabetes, University of Colorado Anschutz Medical Campus, Aurora, CO 80045, USA.<br /><searchLink fieldCode="AU" term="%22Segarra+A%22">Segarra A</searchLink>; Department of Nephrology, Hospital Universitario Arnau de Vilanova, Lleida 25198, Spain.<br /><searchLink fieldCode="AU" term="%22Martinez+C%22">Martinez C</searchLink>; Renal Physiopathology Group, Vall d'Hebron Research Institute (VHIR), Barcelona 08035, Spain.<br /><searchLink fieldCode="AU" term="%22Bjornstad+P%22">Bjornstad P</searchLink>; Division of Endocrinology, Metabolism, and Nutrition, University of Washington School of Medicine, Seattle, WA 98109, USA.; Department of Pediatrics, Section of Pediatric Endocrinology, Children's Hospital Colorado and University of Colorado Anschutz Medical Campus, Aurora, CO 80045, USA.; Department of Medicine, Division of Renal Diseases and Hypertension, University of Colorado Anschutz Medical Campus, Aurora, CO 80045, USA.<br /><searchLink fieldCode="AU" term="%22Lucia+MS%22">Lucia MS</searchLink>; Department of Pathology, University of Colorado Anschutz Medical Campus, Aurora, CO 80045, USA.<br /><searchLink fieldCode="AU" term="%22Schaefer+F%22">Schaefer F</searchLink>; Pediatric Nephrology Division, Heidelberg University Hospital, Heidelberg 69120, Germany.<br /><searchLink fieldCode="AU" term="%22Yilmaz+A%22">Yilmaz A</searchLink>; Istanbul Faculty of Medicine, Istanbul University, Istanbul 34093, Türkiye.<br /><searchLink fieldCode="AU" term="%22Zurowska+A%22">Zurowska A</searchLink>; Department of Pediatric and Adolescent Nephrology, Medical University of Gdansk, Gdansk 80-210, Poland.<br /><searchLink fieldCode="AU" term="%22Wang+X%22">Wang X</searchLink>; Kidney and Urinary Tract Center, Abigail Wexner Research Institute at Nationwide Children's Hospital, Columbus, OH 43205, USA.<br /><searchLink fieldCode="AU" term="%22McCown+PJ%22">McCown PJ</searchLink>; Division of Nephrology, University of Michigan, Ann Arbor, MI 48109, USA.<br /><searchLink fieldCode="AU" term="%22Eddy+S%22">Eddy S</searchLink>; Division of Nephrology, University of Michigan, Ann Arbor, MI 48109, USA.<br /><searchLink fieldCode="AU" term="%22Hartman+J%22">Hartman J</searchLink>; Division of Nephrology, University of Michigan, Ann Arbor, MI 48109, USA.<br /><searchLink fieldCode="AU" term="%22Mariani+L%22">Mariani L</searchLink>; Division of Nephrology, University of Michigan, Ann Arbor, MI 48109, USA.<br /><searchLink fieldCode="AU" term="%22Kretzler+M%22">Kretzler M</searchLink>; Division of Nephrology, University of Michigan, Ann Arbor, MI 48109, USA.<br /><searchLink fieldCode="AU" term="%22Zhu+Y%22">Zhu Y</searchLink>; Department of Surgery, University of Colorado Anschutz Medical Campus, Aurora, CO 80045, USA.<br /><searchLink fieldCode="AU" term="%22Bouts+AHM%22">Bouts AHM</searchLink>; Department of Pediatric Nephrology, Emma Children's Hospital, Amsterdam University Medical Centers, University of Amsterdam, Amsterdam 1105, Netherlands.<br /><searchLink fieldCode="AU" term="%22Levtchenko+EN%22">Levtchenko EN</searchLink>; Department of Pediatric Nephrology, Emma Children's Hospital, Amsterdam University Medical Centers, University of Amsterdam, Amsterdam 1105, Netherlands.<br /><searchLink fieldCode="AU" term="%22Dougherty+JA%22">Dougherty JA</searchLink>; Center for Clinical and Translational Research, Abigail Wexner Research Institute at Nationwide Children's Hospital, Columbus, OH 43205, USA.<br /><searchLink fieldCode="AU" term="%22Smoyer+WE%22">Smoyer WE</searchLink>; Center for Clinical and Translational Research, Abigail Wexner Research Institute at Nationwide Children's Hospital, Columbus, OH 43205, USA.<br /><searchLink fieldCode="AU" term="%22Kerlin+BA%22">Kerlin BA</searchLink>; Center for Clinical and Translational Research, Abigail Wexner Research Institute at Nationwide Children's Hospital, Columbus, OH 43205, USA.<br /><searchLink fieldCode="AU" term="%22Kallash+M%22">Kallash M</searchLink>; Division of Pediatric Nephrology, Nationwide Children's Hospital, Columbus, OH 43205, USA.<br /><searchLink fieldCode="AU" term="%22Soranno+DE%22">Soranno DE</searchLink>; Department of Pediatrics, Section of Nephrology, Indiana University School of Medicine, Indianapolis, IN 46202, USA.<br /><searchLink fieldCode="AU" term="%22Cabrera-Sevilla+JE%22">Cabrera-Sevilla JE</searchLink>; Department of Pediatrics, Division of Pediatric Nephrology, Hospital Universitario Santa Lucia, Cartagena 30202, Spain.<br /><searchLink fieldCode="AU" term="%22Gonzalez-Rodriguez+JD%22">Gonzalez-Rodriguez JD</searchLink>; Department of Pediatrics, Division of Pediatric Nephrology, Hospital Universitario Santa Lucia, Cartagena 30202, Spain.<br /><searchLink fieldCode="AU" term="%22Siegele+BJ%22">Siegele BJ</searchLink>; Department of Pathology and Laboratory Medicine, Children's Hospital Colorado, Aurora, CO 80045, USA.<br /><searchLink fieldCode="AU" term="%22Tsuji+S%22">Tsuji S</searchLink>; Department of Pediatrics, Kansai Medical University, Osaka 573-1191, Japan.<br /><searchLink fieldCode="AU" term="%22Kaneko+K%22">Kaneko K</searchLink>; Department of Pediatrics, Kansai Medical University, Osaka 573-1191, Japan.<br /><searchLink fieldCode="AU" term="%22Sethna+CB%22">Sethna CB</searchLink>; Division of Pediatric Nephrology, Cohen Children's Medical Center, New York, NY 11042, USA.<br /><searchLink fieldCode="AU" term="%22Srivastava+T%22">Srivastava T</searchLink>; Pediatric Nephrology, Children's Mercy Hospital, Kansas City, MO 64108, USA.<br /><searchLink fieldCode="AU" term="%22Bitzer+M%22">Bitzer M</searchLink>; Division of Nephrology, University of Michigan, Ann Arbor, MI 48109, USA.<br /><searchLink fieldCode="AU" term="%22O'Connor+CL%22">O'Connor CL</searchLink>; Division of Nephrology, University of Michigan, Ann Arbor, MI 48109, USA.<br /><searchLink fieldCode="AU" term="%22Dimberg+A%22">Dimberg A</searchLink>; Department of Immunology, Genetics and Pathology, Science for Life Laboratory, Rudbeck Laboratory, Uppsala University, Uppsala 75185, Sweden.<br /><searchLink fieldCode="AU" term="%22Zhao+S%22">Zhao S</searchLink>; Department of Medicine, Division of Nephrology, Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA.<br /><searchLink fieldCode="AU" term="%22Yu+L%22">Yu L</searchLink>; Department of Medicine, Division of Nephrology, Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA.<br /><searchLink fieldCode="AU" term="%22Thurman+JM%22">Thurman JM</searchLink>; Department of Medicine, Division of Renal Diseases and Hypertension, University of Colorado Anschutz Medical Campus, Aurora, CO 80045, USA.<br /><searchLink fieldCode="AU" term="%22Johnson+RJ%22">Johnson RJ</searchLink>; Department of Medicine, Division of Renal Diseases and Hypertension, University of Colorado Anschutz Medical Campus, Aurora, CO 80045, USA.<br /><searchLink fieldCode="AU" term="%22Cara-Fuentes+G%22">Cara-Fuentes G</searchLink>; Department of Pediatrics, Section of Pediatric Nephrology, Children's Hospital Colorado, Aurora, CO 80045, USA.; Kidney and Urinary Tract Center, Abigail Wexner Research Institute at Nationwide Children's Hospital, Columbus, OH 43205, USA.; Department of Medicine, Division of Renal Diseases and Hypertension, University of Colorado Anschutz Medical Campus, Aurora, CO 80045, USA.
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            NameFull: Kaneko K
      – PersonEntity:
          Name:
            NameFull: Sethna CB
      – PersonEntity:
          Name:
            NameFull: Srivastava T
      – PersonEntity:
          Name:
            NameFull: Bitzer M
      – PersonEntity:
          Name:
            NameFull: O'Connor CL
      – PersonEntity:
          Name:
            NameFull: Dimberg A
      – PersonEntity:
          Name:
            NameFull: Zhao S
      – PersonEntity:
          Name:
            NameFull: Yu L
      – PersonEntity:
          Name:
            NameFull: Thurman JM
      – PersonEntity:
          Name:
            NameFull: Johnson RJ
      – PersonEntity:
          Name:
            NameFull: Cara-Fuentes G
    IsPartOfRelationships:
      – BibEntity:
          Dates:
            – D: 14
              M: 01
              Text: 2026 Jan 14
              Type: published
              Y: 2026
          Identifiers:
            – Type: issn-electronic
              Value: 1946-6242
          Numbering:
            – Type: volume
              Value: 18
            – Type: issue
              Value: 832
          Titles:
            – TitleFull: Science translational medicine
              Type: main
ResultId 1