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CD47 destabilization via manipulating the SPOP-USP2 axis augments macrophage phagocytosis and cancer immunotherapy.

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Title: CD47 destabilization via manipulating the SPOP-USP2 axis augments macrophage phagocytosis and cancer immunotherapy.
Authors: Yan P; Department of Pathology, Beth Israel Deaconess Medical Center, Boston, Massachusetts, USA., Bu X; Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, Massachusetts, USA., Hou T; Department of Pathology, Beth Israel Deaconess Medical Center, Boston, Massachusetts, USA., Chen L; Department of Pathology, Beth Israel Deaconess Medical Center, Boston, Massachusetts, USA., Zhong G; Institute of Modern Biology, Nanjing University, Nanjing, Jiangsu, China., Huang D; Department of Pathology, Beth Israel Deaconess Medical Center, Boston, Massachusetts, USA., Wang J; Department of Pathology, Beth Israel Deaconess Medical Center, Boston, Massachusetts, USA., Qi Y; Department of Pathology, Beth Israel Deaconess Medical Center, Boston, Massachusetts, USA., Jiang W; Department of Pathology, Beth Israel Deaconess Medical Center, Boston, Massachusetts, USA., Li Z; Institute of Modern Biology, Nanjing University, Nanjing, Jiangsu, China., Xue X; Department of Neurology & F.M. Kirby Neurobiology Center, Boston Children's Hospital, Boston, Massachusetts, USA., Gao Y; Department of Urology, The First Affiliated Hospital of Xi'an Jiaotong University, Xi'an, Shaanxi, China., Liu J; Department of Urology, The First Affiliated Hospital of Xi'an Jiaotong University, Xi'an, Shaanxi, China., Inuzuka H; Department of Pathology, Beth Israel Deaconess Medical Center, Boston, Massachusetts, USA., Freeman GJ; Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, Massachusetts, USA wwei2@bidmc.harvard.edu xdai@nju.edu.cn gordon_freeman@dfci.harvard.edu., Wei W; Department of Pathology, Beth Israel Deaconess Medical Center, Boston, Massachusetts, USA wwei2@bidmc.harvard.edu xdai@nju.edu.cn gordon_freeman@dfci.harvard.edu., Dai X; Department of Pathology, Beth Israel Deaconess Medical Center, Boston, Massachusetts, USA wwei2@bidmc.harvard.edu xdai@nju.edu.cn gordon_freeman@dfci.harvard.edu.; Institute of Modern Biology, Nanjing University, Nanjing, Jiangsu, China.; Division of Hepatobiliary and Transplantation Surgery, Department of General Surgery, Nanjing Drum Tower Hospital, Nanjing University, Nanjing, Jiangsu, China.
Source: Journal for immunotherapy of cancer [J Immunother Cancer] 2026 Jan 14; Vol. 14 (1). Date of Electronic Publication: 2026 Jan 14.
Publication Type: Journal Article
Journal Info: Publisher: BMJ Publishing Group Ltd Country of Publication: England NLM ID: 101620585 Publication Model: Electronic Cited Medium: Internet ISSN: 2051-1426 (Electronic) Linking ISSN: 20511426 NLM ISO Abbreviation: J Immunother Cancer Subsets: MEDLINE
Database: MEDLINE Ultimate
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  Data: CD47 destabilization via manipulating the SPOP-USP2 axis augments macrophage phagocytosis and cancer immunotherapy.
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  Data: <searchLink fieldCode="AU" term="%22Yan+P%22">Yan P</searchLink>; Department of Pathology, Beth Israel Deaconess Medical Center, Boston, Massachusetts, USA.<br /><searchLink fieldCode="AU" term="%22Bu+X%22">Bu X</searchLink>; Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, Massachusetts, USA.<br /><searchLink fieldCode="AU" term="%22Hou+T%22">Hou T</searchLink>; Department of Pathology, Beth Israel Deaconess Medical Center, Boston, Massachusetts, USA.<br /><searchLink fieldCode="AU" term="%22Chen+L%22">Chen L</searchLink>; Department of Pathology, Beth Israel Deaconess Medical Center, Boston, Massachusetts, USA.<br /><searchLink fieldCode="AU" term="%22Zhong+G%22">Zhong G</searchLink>; Institute of Modern Biology, Nanjing University, Nanjing, Jiangsu, China.<br /><searchLink fieldCode="AU" term="%22Huang+D%22">Huang D</searchLink>; Department of Pathology, Beth Israel Deaconess Medical Center, Boston, Massachusetts, USA.<br /><searchLink fieldCode="AU" term="%22Wang+J%22">Wang J</searchLink>; Department of Pathology, Beth Israel Deaconess Medical Center, Boston, Massachusetts, USA.<br /><searchLink fieldCode="AU" term="%22Qi+Y%22">Qi Y</searchLink>; Department of Pathology, Beth Israel Deaconess Medical Center, Boston, Massachusetts, USA.<br /><searchLink fieldCode="AU" term="%22Jiang+W%22">Jiang W</searchLink>; Department of Pathology, Beth Israel Deaconess Medical Center, Boston, Massachusetts, USA.<br /><searchLink fieldCode="AU" term="%22Li+Z%22">Li Z</searchLink>; Institute of Modern Biology, Nanjing University, Nanjing, Jiangsu, China.<br /><searchLink fieldCode="AU" term="%22Xue+X%22">Xue X</searchLink>; Department of Neurology & F.M. Kirby Neurobiology Center, Boston Children's Hospital, Boston, Massachusetts, USA.<br /><searchLink fieldCode="AU" term="%22Gao+Y%22">Gao Y</searchLink>; Department of Urology, The First Affiliated Hospital of Xi'an Jiaotong University, Xi'an, Shaanxi, China.<br /><searchLink fieldCode="AU" term="%22Liu+J%22">Liu J</searchLink>; Department of Urology, The First Affiliated Hospital of Xi'an Jiaotong University, Xi'an, Shaanxi, China.<br /><searchLink fieldCode="AU" term="%22Inuzuka+H%22">Inuzuka H</searchLink>; Department of Pathology, Beth Israel Deaconess Medical Center, Boston, Massachusetts, USA.<br /><searchLink fieldCode="AU" term="%22Freeman+GJ%22">Freeman GJ</searchLink>; Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, Massachusetts, USA wwei2@bidmc.harvard.edu xdai@nju.edu.cn gordon_freeman@dfci.harvard.edu.<br /><searchLink fieldCode="AU" term="%22Wei+W%22">Wei W</searchLink>; Department of Pathology, Beth Israel Deaconess Medical Center, Boston, Massachusetts, USA wwei2@bidmc.harvard.edu xdai@nju.edu.cn gordon_freeman@dfci.harvard.edu.<br /><searchLink fieldCode="AU" term="%22Dai+X%22">Dai X</searchLink>; Department of Pathology, Beth Israel Deaconess Medical Center, Boston, Massachusetts, USA wwei2@bidmc.harvard.edu xdai@nju.edu.cn gordon_freeman@dfci.harvard.edu.; Institute of Modern Biology, Nanjing University, Nanjing, Jiangsu, China.; Division of Hepatobiliary and Transplantation Surgery, Department of General Surgery, Nanjing Drum Tower Hospital, Nanjing University, Nanjing, Jiangsu, China.
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  Data: <searchLink fieldCode="JN" term="%22101620585%22">Journal for immunotherapy of cancer</searchLink> [J Immunother Cancer] 2026 Jan 14; Vol. 14 (1). <i>Date of Electronic Publication: </i>2026 Jan 14.
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  Data: <i>Publisher: </i><searchLink fieldCode="PB" term="%22BMJ+Publishing+Group+Ltd%22">BMJ Publishing Group Ltd </searchLink><i>Country of Publication: </i>England <i>NLM ID: </i>101620585 <i>Publication Model: </i>Electronic <i>Cited Medium: </i>Internet <i>ISSN: </i>2051-1426 (Electronic) <i>Linking ISSN: </i><searchLink fieldCode="IS" term="%2220511426%22">20511426 </searchLink><i>NLM ISO Abbreviation: </i>J Immunother Cancer <i>Subsets: </i>MEDLINE
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        Value: 10.1136/jitc-2025-013498
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      – TitleFull: CD47 destabilization via manipulating the SPOP-USP2 axis augments macrophage phagocytosis and cancer immunotherapy.
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