An Adcy3 coding mutation causes partial loss of enzymatic function, contributing to obesity in a rat model by reducing lipolysis.

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Title: An Adcy3 coding mutation causes partial loss of enzymatic function, contributing to obesity in a rat model by reducing lipolysis.
Authors: Fitzpatrick MK; Department of Internal Medicine, Section on Molecular Medicine, Wake Forest University School of Medicine, Winston-Salem NC, USA., Seshie O; Department of Internal Medicine, Section on Molecular Medicine, Wake Forest University School of Medicine, Winston-Salem NC, USA., Scott C; Department of Internal Medicine, Section on Molecular Medicine, Wake Forest University School of Medicine, Winston-Salem NC, USA., Vora A; Department of Internal Medicine, Section on Molecular Medicine, Wake Forest University School of Medicine, Winston-Salem NC, USA., Seramur ME; Department of Internal Medicine, Section on Molecular Medicine, Wake Forest University School of Medicine, Winston-Salem NC, USA., Beeson A; Department of Internal Medicine, Section on Molecular Medicine, Wake Forest University School of Medicine, Winston-Salem NC, USA., Adrian L; Department of Internal Medicine, Section on Molecular Medicine, Wake Forest University School of Medicine, Winston-Salem NC, USA., Grzybowski M; Department of Physiology, Medical College of Wisconsin, Milwaukee WI, USA., Klotz J; Department of Physiology, Medical College of Wisconsin, Milwaukee WI, USA., Geurts AM; Department of Physiology, Medical College of Wisconsin, Milwaukee WI, USA., Key CC; Department of Internal Medicine, Section on Molecular Medicine, Wake Forest University School of Medicine, Winston-Salem NC, USA.; Department of Internal Medicine, Section on Pulmonary, Critical Care, Allergy and Immunologic Diseases, Wake Forest University School of Medicine, Winston-Salem NC, USA., Woods LCS; Department of Internal Medicine, Section on Molecular Medicine, Wake Forest University School of Medicine, Winston-Salem NC, USA.
Source: Research square [Res Sq] 2026 Jan 09. Date of Electronic Publication: 2026 Jan 09.
Publication Type: Journal Article; Preprint
Journal Info: Country of Publication: United States NLM ID: 101768035 Publication Model: Electronic Cited Medium: Internet ISSN: 2693-5015 (Electronic) Linking ISSN: 26935015 NLM ISO Abbreviation: Res Sq Subsets: PubMed not MEDLINE
Database: MEDLINE Ultimate
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  Data: <searchLink fieldCode="AU" term="%22Fitzpatrick+MK%22">Fitzpatrick MK</searchLink>; Department of Internal Medicine, Section on Molecular Medicine, Wake Forest University School of Medicine, Winston-Salem NC, USA.<br /><searchLink fieldCode="AU" term="%22Seshie+O%22">Seshie O</searchLink>; Department of Internal Medicine, Section on Molecular Medicine, Wake Forest University School of Medicine, Winston-Salem NC, USA.<br /><searchLink fieldCode="AU" term="%22Scott+C%22">Scott C</searchLink>; Department of Internal Medicine, Section on Molecular Medicine, Wake Forest University School of Medicine, Winston-Salem NC, USA.<br /><searchLink fieldCode="AU" term="%22Vora+A%22">Vora A</searchLink>; Department of Internal Medicine, Section on Molecular Medicine, Wake Forest University School of Medicine, Winston-Salem NC, USA.<br /><searchLink fieldCode="AU" term="%22Seramur+ME%22">Seramur ME</searchLink>; Department of Internal Medicine, Section on Molecular Medicine, Wake Forest University School of Medicine, Winston-Salem NC, USA.<br /><searchLink fieldCode="AU" term="%22Beeson+A%22">Beeson A</searchLink>; Department of Internal Medicine, Section on Molecular Medicine, Wake Forest University School of Medicine, Winston-Salem NC, USA.<br /><searchLink fieldCode="AU" term="%22Adrian+L%22">Adrian L</searchLink>; Department of Internal Medicine, Section on Molecular Medicine, Wake Forest University School of Medicine, Winston-Salem NC, USA.<br /><searchLink fieldCode="AU" term="%22Grzybowski+M%22">Grzybowski M</searchLink>; Department of Physiology, Medical College of Wisconsin, Milwaukee WI, USA.<br /><searchLink fieldCode="AU" term="%22Klotz+J%22">Klotz J</searchLink>; Department of Physiology, Medical College of Wisconsin, Milwaukee WI, USA.<br /><searchLink fieldCode="AU" term="%22Geurts+AM%22">Geurts AM</searchLink>; Department of Physiology, Medical College of Wisconsin, Milwaukee WI, USA.<br /><searchLink fieldCode="AU" term="%22Key+CC%22">Key CC</searchLink>; Department of Internal Medicine, Section on Molecular Medicine, Wake Forest University School of Medicine, Winston-Salem NC, USA.; Department of Internal Medicine, Section on Pulmonary, Critical Care, Allergy and Immunologic Diseases, Wake Forest University School of Medicine, Winston-Salem NC, USA.<br /><searchLink fieldCode="AU" term="%22Woods+LCS%22">Woods LCS</searchLink>; Department of Internal Medicine, Section on Molecular Medicine, Wake Forest University School of Medicine, Winston-Salem NC, USA.
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              Text: 2026 Jan 09
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