Dual CDK4/6-PI3K/mTOR inhibition reinforces cytostatic programs and tumor control in preclinical models of primary and metastatic osteosarcoma.

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Title: Dual CDK4/6-PI3K/mTOR inhibition reinforces cytostatic programs and tumor control in preclinical models of primary and metastatic osteosarcoma.
Authors: Barghi F; Department of Medical and Molecular Genetics, Indiana University School of Medicine (IUSM), Indianapolis, IN, USA; Herman B Wells Center for Pediatric Research, IUSM, Indianapolis, IN, USA., Saadatzadeh MR; Herman B Wells Center for Pediatric Research, IUSM, Indianapolis, IN, USA; Department of Pediatrics, Division of Pediatric Hematology/Oncology, IUSM, Indianapolis, IN, USA., Dobrota EA; Herman B Wells Center for Pediatric Research, IUSM, Indianapolis, IN, USA; Department of Pediatrics, Division of Pediatric Hematology/Oncology, IUSM, Indianapolis, IN, USA., Shannon HE; Herman B Wells Center for Pediatric Research, IUSM, Indianapolis, IN, USA; Department of Pediatrics, Division of Pediatric Hematology/Oncology, IUSM, Indianapolis, IN, USA., Bailey BJ; Herman B Wells Center for Pediatric Research, IUSM, Indianapolis, IN, USA; Department of Pediatrics, Division of Pediatric Hematology/Oncology, IUSM, Indianapolis, IN, USA., Young C; Herman B Wells Center for Pediatric Research, IUSM, Indianapolis, IN, USA; Department of Pediatrics, Division of Pediatric Hematology/Oncology, IUSM, Indianapolis, IN, USA., Malko R; Department of Medical and Molecular Genetics, Indiana University School of Medicine (IUSM), Indianapolis, IN, USA; Herman B Wells Center for Pediatric Research, IUSM, Indianapolis, IN, USA; Department of Pediatrics, Division of Pediatric Hematology/Oncology, IUSM, Indianapolis, IN, USA., Justice R; Herman B Wells Center for Pediatric Research, IUSM, Indianapolis, IN, USA; Department of Pediatrics, Division of Pediatric Hematology/Oncology, IUSM, Indianapolis, IN, USA., Riyahi N; Herman B Wells Center for Pediatric Research, IUSM, Indianapolis, IN, USA; Department of Pediatrics, Division of Pediatric Hematology/Oncology, IUSM, Indianapolis, IN, USA; Department of Biochemistry & Molecular Biology, and Pharmacology IUSM, Indianapolis, IN, USA., Davis C; Herman B Wells Center for Pediatric Research, IUSM, Indianapolis, IN, USA., Bijangi-Vishehsaraei K; Herman B Wells Center for Pediatric Research, IUSM, Indianapolis, IN, USA; Department of Pediatrics, Division of Pediatric Hematology/Oncology, IUSM, Indianapolis, IN, USA., Kreklau K; Herman B Wells Center for Pediatric Research, IUSM, Indianapolis, IN, USA; Department of Pediatrics, Division of Pediatric Hematology/Oncology, IUSM, Indianapolis, IN, USA., Stevens LK; Herman B Wells Center for Pediatric Research, IUSM, Indianapolis, IN, USA; Department of Pediatrics, Division of Pediatric Hematology/Oncology, IUSM, Indianapolis, IN, USA., Koenig J; Herman B Wells Center for Pediatric Research, IUSM, Indianapolis, IN, USA; Department of Pediatrics, Division of Pediatric Hematology/Oncology, IUSM, Indianapolis, IN, USA., Sulayman S; Department of Medical and Molecular Genetics, Indiana University School of Medicine (IUSM), Indianapolis, IN, USA; Department of BioHealth Informatics, School of Informatics and Computing, Indiana University Indianapolis, Indianapolis, IN, USA; Center for Computational Biology and Bioinformatics, IUSM, Indianapolis, IN, USA., Liu S; Department of Medical and Molecular Genetics, Indiana University School of Medicine (IUSM), Indianapolis, IN, USA; Department of BioHealth Informatics, School of Informatics and Computing, Indiana University Indianapolis, Indianapolis, IN, USA; Center for Computational Biology and Bioinformatics, IUSM, Indianapolis, IN, USA., Wan J; Department of Medical and Molecular Genetics, Indiana University School of Medicine (IUSM), Indianapolis, IN, USA; Department of BioHealth Informatics, School of Informatics and Computing, Indiana University Indianapolis, Indianapolis, IN, USA; Center for Computational Biology and Bioinformatics, IUSM, Indianapolis, IN, USA., Trowbridge MA; Preclinical Modeling and Therapeutics Core, Indiana University Melvin and Bren Simon Comprehensive Cancer Center (IUSCCC), IUSM, Indianapolis, IN, USA., Coy K; Preclinical Modeling and Therapeutics Core, Indiana University Melvin and Bren Simon Comprehensive Cancer Center (IUSCCC), IUSM, Indianapolis, IN, USA., Kennedy FM; Preclinical Modeling and Therapeutics Core, Indiana University Melvin and Bren Simon Comprehensive Cancer Center (IUSCCC), IUSM, Indianapolis, IN, USA., Sinn AL; Preclinical Modeling and Therapeutics Core, Indiana University Melvin and Bren Simon Comprehensive Cancer Center (IUSCCC), IUSM, Indianapolis, IN, USA., Just M; Department of Pediatrics, Division of Pediatric Hematology/Oncology, IUSM, Indianapolis, IN, USA., Jackson KW; Department of Pediatrics, Division of Pediatric Hematology/Oncology, IUSM, Indianapolis, IN, USA., Sandusky G; Department of Pathology and Laboratory Medicine, IUSM, Indianapolis, IN, USA., Wurtz LD; Department of Orthopedic Surgery, IUSM, Indianapolis, IN, USA., Collier CD; Department of Orthopedic Surgery, IUSM, Indianapolis, IN, USA., Mitchell D; Herman B Wells Center for Pediatric Research, IUSM, Indianapolis, IN, USA; Department of Pediatrics, Division of Pediatric Hematology/Oncology, IUSM, Indianapolis, IN, USA., Seiden EE; Department of Anatomy, Cell Biology and Physiology, IUSM, Indianapolis, IN, USA., Greenfield EM; Department of Orthopedic Surgery, IUSM, Indianapolis, IN, USA; Department of Anatomy, Cell Biology and Physiology, IUSM, Indianapolis, IN, USA., Doud E; Department of Biochemistry & Molecular Biology, and Pharmacology IUSM, Indianapolis, IN, USA; Center for Proteome Analysis, IUSCCC, IUSM, Indianapolis, IN, USA., Mosley A; Department of Medical and Molecular Genetics, Indiana University School of Medicine (IUSM), Indianapolis, IN, USA; Department of Biochemistry & Molecular Biology, and Pharmacology IUSM, Indianapolis, IN, USA; Center for Proteome Analysis, IUSCCC, IUSM, Indianapolis, IN, USA., Angus SP; Herman B Wells Center for Pediatric Research, IUSM, Indianapolis, IN, USA; Department of Pediatrics, Division of Pediatric Hematology/Oncology, IUSM, Indianapolis, IN, USA; Department of Biochemistry & Molecular Biology, and Pharmacology IUSM, Indianapolis, IN, USA., Ferguson MJ; Department of Pediatrics, Division of Pediatric Hematology/Oncology, University of Louisville, KY, USA., Pandya PH; Department of Medical and Molecular Genetics, Indiana University School of Medicine (IUSM), Indianapolis, IN, USA; Herman B Wells Center for Pediatric Research, IUSM, Indianapolis, IN, USA; Department of Pediatrics, Division of Pediatric Hematology/Oncology, IUSM, Indianapolis, IN, USA. Electronic address: phpandya@iu.edu., Pollok KE; Department of Medical and Molecular Genetics, Indiana University School of Medicine (IUSM), Indianapolis, IN, USA; Herman B Wells Center for Pediatric Research, IUSM, Indianapolis, IN, USA; Department of Pediatrics, Division of Pediatric Hematology/Oncology, IUSM, Indianapolis, IN, USA; Department of Biochemistry & Molecular Biology, and Pharmacology IUSM, Indianapolis, IN, USA; Preclinical Modeling and Therapeutics Core, Indiana University Melvin and Bren Simon Comprehensive Cancer Center (IUSCCC), IUSM, Indianapolis, IN, USA. Electronic address: kpollok@iu.edu.
Source: Neoplasia (New York, N.Y.) [Neoplasia] 2026 Feb; Vol. 72, pp. 101266. Date of Electronic Publication: 2026 Jan 15.
Publication Type: Journal Article
Journal Info: Publisher: Elsevier Country of Publication: United States NLM ID: 100886622 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1476-5586 (Electronic) Linking ISSN: 14765586 NLM ISO Abbreviation: Neoplasia Subsets: MEDLINE
Database: MEDLINE Ultimate
Description
ISSN:1476-5586
DOI:10.1016/j.neo.2025.101266