Vertical RAS pathway inhibition in pancreatic cancer drives therapeutically exploitable mitochondrial alterations.

Saved in:
Bibliographic Details
Title: Vertical RAS pathway inhibition in pancreatic cancer drives therapeutically exploitable mitochondrial alterations.
Authors: Hafner P; Department of General and Visceral Surgery, Center for Surgery, Faculty of Medicine, Medical Center - University of Freiburg, Freiburg, Germany.; Faculty of Biology, University of Freiburg, Freiburg, Germany., Keller SJ; Department of General and Visceral Surgery, Center for Surgery, Faculty of Medicine, Medical Center - University of Freiburg, Freiburg, Germany.; Faculty of Biology, University of Freiburg, Freiburg, Germany., Chen X; Department of General and Visceral Surgery, Center for Surgery, Faculty of Medicine, Medical Center - University of Freiburg, Freiburg, Germany.; Department of Hepatobiliary and Pancreatic Surgery, The Affiliated Cancer Hospital of Zhengzhou University & Henan Cancer Hospital, Zhengzhou, China., Alrawashdeh A; Department of General and Visceral Surgery, Center for Surgery, Faculty of Medicine, Medical Center - University of Freiburg, Freiburg, Germany.; Faculty of Biology, University of Freiburg, Freiburg, Germany., Jumaa H; Department of General and Visceral Surgery, Center for Surgery, Faculty of Medicine, Medical Center - University of Freiburg, Freiburg, Germany., Nollmann FI; Department of General and Visceral Surgery, Center for Surgery, Faculty of Medicine, Medical Center - University of Freiburg, Freiburg, Germany., Besson S; Department of General and Visceral Surgery, Center for Surgery, Faculty of Medicine, Medical Center - University of Freiburg, Freiburg, Germany., Kemming J; Department of General and Visceral Surgery, Center for Surgery, Faculty of Medicine, Medical Center - University of Freiburg, Freiburg, Germany.; Faculty of Biology, University of Freiburg, Freiburg, Germany., Gorka O; Institute of Neuropathology, Faculty of Medicine, Medical Center - University of Freiburg, Freiburg, Germany., Das T; Institute of Medical Bioinformatics and Systems Medicine, Faculty of Medicine, Medical Center - University of Freiburg, Freiburg, Germany., Appiah B; Institute of Medical Bioinformatics and Systems Medicine, Faculty of Medicine, Medical Center - University of Freiburg, Freiburg, Germany., Lehmann A; Faculty of Biology, University of Freiburg, Freiburg, Germany.; Institute of Medical Bioinformatics and Systems Medicine, Faculty of Medicine, Medical Center - University of Freiburg, Freiburg, Germany., Li M; Institute of Surgical Pathology, Faculty of Medicine, Medical Center - University of Freiburg, Freiburg, Germany., Apostolova P; Division of Hematology, University Hospital Basel, Basel, Switzerland., Bengsch B; Department of Internal Medicine II, Medical Center - University of Freiburg, Freiburg, Germany.; CIBSS - Centre for Integrative Biological Signalling Studies, University of Freiburg, Freiburg, Germany.; German Cancer Consortium (DKTK), Partner site Freiburg, a partnership between DKFZ and Medical Center - University of Freiburg, Freiburg, Germany., Zeiser R; CIBSS - Centre for Integrative Biological Signalling Studies, University of Freiburg, Freiburg, Germany.; German Cancer Consortium (DKTK), Partner site Freiburg, a partnership between DKFZ and Medical Center - University of Freiburg, Freiburg, Germany.; Department of Medicine I, Faculty of Medicine, Medical Center - University of Freiburg, Freiburg, Germany., Tholen S; Institute of Surgical Pathology, Faculty of Medicine, Medical Center - University of Freiburg, Freiburg, Germany., Schilling O; Institute of Surgical Pathology, Faculty of Medicine, Medical Center - University of Freiburg, Freiburg, Germany., Groß O; Institute of Neuropathology, Faculty of Medicine, Medical Center - University of Freiburg, Freiburg, Germany.; CIBSS - Centre for Integrative Biological Signalling Studies, University of Freiburg, Freiburg, Germany., Vlachos A; Faculty of Medicine, Department of Neuroanatomy - University of Freiburg, Freiburg, Germany., Wittel UA; Department of General and Visceral Surgery, Center for Surgery, Faculty of Medicine, Medical Center - University of Freiburg, Freiburg, Germany., von Elverfeldt D; Division of Medical Physics, Department of Diagnostic and Interventional Radiology, Faculty of Medicine, University Medical Center Freiburg, University of Freiburg, Freiburg, Germany., Reichardt W; Division of Medical Physics, Department of Diagnostic and Interventional Radiology, Faculty of Medicine, University Medical Center Freiburg, University of Freiburg, Freiburg, Germany., Boerries M; Institute of Medical Bioinformatics and Systems Medicine, Faculty of Medicine, Medical Center - University of Freiburg, Freiburg, Germany.; German Cancer Consortium (DKTK), Partner site Freiburg, a partnership between DKFZ and Medical Center - University of Freiburg, Freiburg, Germany., Andrieux G; Institute of Medical Bioinformatics and Systems Medicine, Faculty of Medicine, Medical Center - University of Freiburg, Freiburg, Germany., Heynen GJ; Berlin Center for Advanced Therapies (BeCAT), Charité - Universitätsmedizin Berlin, Berlin, Germany., Fichtner-Feigl S; Department of General and Visceral Surgery, Center for Surgery, Faculty of Medicine, Medical Center - University of Freiburg, Freiburg, Germany., Hannibal L; CIBSS - Centre for Integrative Biological Signalling Studies, University of Freiburg, Freiburg, Germany.; Department of Pediatrics, Faculty of Medicine, Medical Center - University of Freiburg, Freiburg, Germany., Ruess DA; Department of General and Visceral Surgery, Center for Surgery, Faculty of Medicine, Medical Center - University of Freiburg, Freiburg, Germany. dietrich.ruess@uniklinik-freiburg.de.; German Cancer Consortium (DKTK), Partner site Freiburg, a partnership between DKFZ and Medical Center - University of Freiburg, Freiburg, Germany. dietrich.ruess@uniklinik-freiburg.de.
Source: Signal transduction and targeted therapy [Signal Transduct Target Ther] 2026 Jan 16; Vol. 11 (1), pp. 33. Date of Electronic Publication: 2026 Jan 16.
Publication Type: Journal Article
Journal Info: Publisher: Nature Publishing Group Country of Publication: England NLM ID: 101676423 Publication Model: Electronic Cited Medium: Internet ISSN: 2059-3635 (Electronic) Linking ISSN: 20593635 NLM ISO Abbreviation: Signal Transduct Target Ther Subsets: MEDLINE
Database: MEDLINE Ultimate
Description
ISSN:2059-3635
DOI:10.1038/s41392-025-02563-7