PLN-L31A/I40A for the treatment of inherited heart disease caused by PLN-R14del mutations.

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Title: PLN-L31A/I40A for the treatment of inherited heart disease caused by PLN-R14del mutations.
Authors: Chen ZY; State Key Laboratory of Drug Research, the National Center for Drug Screening, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, Shanghai, 201203, China.; School of Pharmacy, University of Chinese Academy of Sciences, Beijing, 100049, China., Guo R; State Key Laboratory of Drug Research, the National Center for Drug Screening, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, Shanghai, 201203, China., Wang M; State Key Laboratory of Drug Research, the National Center for Drug Screening, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, Shanghai, 201203, China., Ji SJ; State Key Laboratory of Drug Research, the National Center for Drug Screening, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, Shanghai, 201203, China.; School of Pharmacy, University of Chinese Academy of Sciences, Beijing, 100049, China.; School of Life Science and Technology, ShanghaiTech University, Shanghai, 200031, China., Zhang JW; State Key Laboratory of Drug Research, the National Center for Drug Screening, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, Shanghai, 201203, China.; School of Pharmacy, University of Chinese Academy of Sciences, Beijing, 100049, China.; School of Life Science and Technology, ShanghaiTech University, Shanghai, 200031, China., Zheng HX; State Key Laboratory of Drug Research, the National Center for Drug Screening, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, Shanghai, 201203, China.; School of Pharmacy, University of Chinese Academy of Sciences, Beijing, 100049, China.; School of Life Science and Technology, ShanghaiTech University, Shanghai, 200031, China., Wang ST; State Key Laboratory of Drug Research, the National Center for Drug Screening, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, Shanghai, 201203, China.; School of Pharmacy, University of Chinese Academy of Sciences, Beijing, 100049, China., Xie X; State Key Laboratory of Drug Research, the National Center for Drug Screening, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, Shanghai, 201203, China. xxie@simm.ac.cn.; School of Pharmacy, University of Chinese Academy of Sciences, Beijing, 100049, China. xxie@simm.ac.cn.; School of Life Science and Technology, ShanghaiTech University, Shanghai, 200031, China. xxie@simm.ac.cn.; Shandong Laboratory of Yantai Drug Discovery, Bohai Rim Advanced Research Institute for Drug Discovery, Yantai, 264119, China. xxie@simm.ac.cn.
Source: Acta pharmacologica Sinica [Acta Pharmacol Sin] 2026 May; Vol. 47 (5), pp. 1191-1203. Date of Electronic Publication: 2026 Jan 16.
Publication Type: Journal Article
Journal Info: Publisher: Nature Publishing Group Country of Publication: United States NLM ID: 100956087 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1745-7254 (Electronic) Linking ISSN: 16714083 NLM ISO Abbreviation: Acta Pharmacol Sin Subsets: MEDLINE
Database: MEDLINE Ultimate
Description
ISSN:1745-7254
DOI:10.1038/s41401-025-01711-7