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PLN-L31A/I40A for the treatment of inherited heart disease caused by PLN-R14del mutations.

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Title: PLN-L31A/I40A for the treatment of inherited heart disease caused by PLN-R14del mutations.
Authors: Chen ZY; State Key Laboratory of Drug Research, the National Center for Drug Screening, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, Shanghai, 201203, China.; School of Pharmacy, University of Chinese Academy of Sciences, Beijing, 100049, China., Guo R; State Key Laboratory of Drug Research, the National Center for Drug Screening, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, Shanghai, 201203, China., Wang M; State Key Laboratory of Drug Research, the National Center for Drug Screening, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, Shanghai, 201203, China., Ji SJ; State Key Laboratory of Drug Research, the National Center for Drug Screening, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, Shanghai, 201203, China.; School of Pharmacy, University of Chinese Academy of Sciences, Beijing, 100049, China.; School of Life Science and Technology, ShanghaiTech University, Shanghai, 200031, China., Zhang JW; State Key Laboratory of Drug Research, the National Center for Drug Screening, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, Shanghai, 201203, China.; School of Pharmacy, University of Chinese Academy of Sciences, Beijing, 100049, China.; School of Life Science and Technology, ShanghaiTech University, Shanghai, 200031, China., Zheng HX; State Key Laboratory of Drug Research, the National Center for Drug Screening, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, Shanghai, 201203, China.; School of Pharmacy, University of Chinese Academy of Sciences, Beijing, 100049, China.; School of Life Science and Technology, ShanghaiTech University, Shanghai, 200031, China., Wang ST; State Key Laboratory of Drug Research, the National Center for Drug Screening, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, Shanghai, 201203, China.; School of Pharmacy, University of Chinese Academy of Sciences, Beijing, 100049, China., Xie X; State Key Laboratory of Drug Research, the National Center for Drug Screening, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, Shanghai, 201203, China. xxie@simm.ac.cn.; School of Pharmacy, University of Chinese Academy of Sciences, Beijing, 100049, China. xxie@simm.ac.cn.; School of Life Science and Technology, ShanghaiTech University, Shanghai, 200031, China. xxie@simm.ac.cn.; Shandong Laboratory of Yantai Drug Discovery, Bohai Rim Advanced Research Institute for Drug Discovery, Yantai, 264119, China. xxie@simm.ac.cn.
Source: Acta pharmacologica Sinica [Acta Pharmacol Sin] 2026 May; Vol. 47 (5), pp. 1191-1203. Date of Electronic Publication: 2026 Jan 16.
Publication Type: Journal Article
Journal Info: Publisher: Nature Publishing Group Country of Publication: United States NLM ID: 100956087 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1745-7254 (Electronic) Linking ISSN: 16714083 NLM ISO Abbreviation: Acta Pharmacol Sin Subsets: MEDLINE
Database: MEDLINE Ultimate
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  Data: PLN-L31A/I40A for the treatment of inherited heart disease caused by PLN-R14del mutations.
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  Data: <searchLink fieldCode="AU" term="%22Chen+ZY%22">Chen ZY</searchLink>; State Key Laboratory of Drug Research, the National Center for Drug Screening, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, Shanghai, 201203, China.; School of Pharmacy, University of Chinese Academy of Sciences, Beijing, 100049, China.<br /><searchLink fieldCode="AU" term="%22Guo+R%22">Guo R</searchLink>; State Key Laboratory of Drug Research, the National Center for Drug Screening, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, Shanghai, 201203, China.<br /><searchLink fieldCode="AU" term="%22Wang+M%22">Wang M</searchLink>; State Key Laboratory of Drug Research, the National Center for Drug Screening, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, Shanghai, 201203, China.<br /><searchLink fieldCode="AU" term="%22Ji+SJ%22">Ji SJ</searchLink>; State Key Laboratory of Drug Research, the National Center for Drug Screening, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, Shanghai, 201203, China.; School of Pharmacy, University of Chinese Academy of Sciences, Beijing, 100049, China.; School of Life Science and Technology, ShanghaiTech University, Shanghai, 200031, China.<br /><searchLink fieldCode="AU" term="%22Zhang+JW%22">Zhang JW</searchLink>; State Key Laboratory of Drug Research, the National Center for Drug Screening, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, Shanghai, 201203, China.; School of Pharmacy, University of Chinese Academy of Sciences, Beijing, 100049, China.; School of Life Science and Technology, ShanghaiTech University, Shanghai, 200031, China.<br /><searchLink fieldCode="AU" term="%22Zheng+HX%22">Zheng HX</searchLink>; State Key Laboratory of Drug Research, the National Center for Drug Screening, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, Shanghai, 201203, China.; School of Pharmacy, University of Chinese Academy of Sciences, Beijing, 100049, China.; School of Life Science and Technology, ShanghaiTech University, Shanghai, 200031, China.<br /><searchLink fieldCode="AU" term="%22Wang+ST%22">Wang ST</searchLink>; State Key Laboratory of Drug Research, the National Center for Drug Screening, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, Shanghai, 201203, China.; School of Pharmacy, University of Chinese Academy of Sciences, Beijing, 100049, China.<br /><searchLink fieldCode="AU" term="%22Xie+X%22">Xie X</searchLink>; State Key Laboratory of Drug Research, the National Center for Drug Screening, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, Shanghai, 201203, China. xxie@simm.ac.cn.; School of Pharmacy, University of Chinese Academy of Sciences, Beijing, 100049, China. xxie@simm.ac.cn.; School of Life Science and Technology, ShanghaiTech University, Shanghai, 200031, China. xxie@simm.ac.cn.; Shandong Laboratory of Yantai Drug Discovery, Bohai Rim Advanced Research Institute for Drug Discovery, Yantai, 264119, China. xxie@simm.ac.cn.
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  Data: <searchLink fieldCode="JN" term="%22100956087%22">Acta pharmacologica Sinica</searchLink> [Acta Pharmacol Sin] 2026 May; Vol. 47 (5), pp. 1191-1203. <i>Date of Electronic Publication: </i>2026 Jan 16.
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  Data: <i>Publisher: </i><searchLink fieldCode="PB" term="%22Nature+Publishing+Group%22">Nature Publishing Group </searchLink><i>Country of Publication: </i>United States <i>NLM ID: </i>100956087 <i>Publication Model: </i>Print-Electronic <i>Cited Medium: </i>Internet <i>ISSN: </i>1745-7254 (Electronic) <i>Linking ISSN: </i><searchLink fieldCode="IS" term="%2216714083%22">16714083 </searchLink><i>NLM ISO Abbreviation: </i>Acta Pharmacol Sin <i>Subsets: </i>MEDLINE
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        Value: 10.1038/s41401-025-01711-7
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              Text: 2026 May
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              Y: 2026
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