Best hypnotic drug choice for rapid sequence induction in the operating room: study protocol for a 3-arm superiority open-labeled randomized controlled trial with blinded evaluation of the primary outcome (the HyPnotiKs study).

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Title: Best hypnotic drug choice for rapid sequence induction in the operating room: study protocol for a 3-arm superiority open-labeled randomized controlled trial with blinded evaluation of the primary outcome (the HyPnotiKs study).
Authors: Grillot N; Université de Nantes, CHU Nantes, Pôle Anesthésie-Réanimation, Service d'Anesthésie Réanimation Chirurgicale, Hôtel Dieu, Nantes, 44093, France. nicolas.grillot@chu-nantes.fr., Volteau C; Nantes Université, CHU Nantes, Direction de la Recherche et de l'innovation, Plateforme de méthodologie et biostatistique, Nantes, 44000, France., Quillet P; Department of Clinical Research, Nantes University Hospital, Nantes, France., Ambrosi X; Université de Nantes, CHU Nantes, Anesthesia and Intensive Care Unit, Hôpital Laennec, Saint-Herblain, France., Caillard A; Anesthesia and Intensive Care Unit, Brest Regional University Hospital, Brest, France., David JS; Anesthesia and Intensive Care Unit, Lyon Sud Regional University Hospital, Hospices Civils de Lyon, Lyon, France., Blet A; Anesthesia and Intensive Care Unit, Croix Rousse University Hospital, Hospices Civils de Lyon, Lyon, France., Bouzat P; Pôle d'Anesthésie-Réanimation, Hôpital Albert Michallon, BP 217, Grenoble, 38043, France., Blanchet L; Anesthesia and Intensive Care Unit, Le Mans Public Hospital, Le Mans, France., Bruneau N; Anesthesia and Intensive Care Unit, Lille Regional University Hospital, Lille, France., Chebbi N; Service Anesthésie et Réanimation, Centre Hospitalier Louis Pasteur, Le Coudray, France., Saint-Genis Q; Anesthesia and Intensive Care Unit, Poitiers University Hospital, Poitiers, France., Figueiredo S; Anesthesia and Intensive Care Unit, Kremlin-Bicêtre University Hospital, Assistance Publique - Hôpitaux de Paris University Hospital, Le Kremlin-Bicêtre, France., Guinot PG; Anesthesia and Intensive Care Unit, Dijon University Hospital, Dijon, France., Joosten A; Department of Anesthesiology and Perioperative Medicine, Ronald Reagan UCLA Medical Center, Los Angeles, USA., Le Guen M; Anesthesia and Intensive Care Unit, Hôpital Foch, Suresnes, France., Labaste F; Anesthesia and Intensive Care Unit, Toulouse University Hospital, Toulouse, France., Lasocki S; Département Anesthésie Réanimation, CHU d'Angers, Université d'Angers, Angers, 49933, France., Oudot M; Anesthesia Unit, Vendée District Hospital Center, La Roche-Sur-Yon, France., Pommier M; Anesthesia and Intensive Care Unit, Toulouse University Hospital, Toulouse, France., Rousseleau D; CHU de Lille, Pole Anesthésie Réanimation, Hôpital Claude Huriez, Lille, France., Verdonk F; Anesthesia and Intensive Care Unit, Saint-Antoine University Hospital, Assistance Publique - Hôpitaux de Paris University Hospital, Paris, France.; Anesthesia and Intensive Care Unit, Tenon University Hospital, Assistance Publique - Hôpitaux de Paris University Hospital, Paris, France., Tching-Sin M; Department of Pharmacy, Nantes University Hospital, Nantes, France., Faurel-Paul E; Department of Clinical Research, Nantes University Hospital, Nantes, France., Counille F; Université de Nantes, CHU Nantes, Pôle Anesthésie-Réanimation, Service d'Anesthésie Réanimation Chirurgicale, Hôtel Dieu, Nantes, 44093, France., Cossé C; Université de Nantes, CHU Nantes, Pôle Anesthésie-Réanimation, Service d'Anesthésie Réanimation Chirurgicale, Hôtel Dieu, Nantes, 44093, France., Flattres Duchaussoy D; Université de Nantes, CHU Nantes, Pôle Anesthésie-Réanimation, Service d'Anesthésie Réanimation Chirurgicale, Hôtel Dieu, Nantes, 44093, France., Cinotti R; Université de Nantes, CHU Nantes, Pôle Anesthésie-Réanimation, Service d'Anesthésie Réanimation Chirurgicale, Hôtel Dieu, Nantes, 44093, France., Roquilly A; Université de Nantes, CHU Nantes, Pôle Anesthésie-Réanimation, Service d'Anesthésie Réanimation Chirurgicale, Hôtel Dieu, Nantes, 44093, France.
Source: Trials [Trials] 2026 Jan 16; Vol. 27 (1), pp. 127. Date of Electronic Publication: 2026 Jan 16.
Publication Type: Journal Article; Clinical Trial Protocol
Journal Info: Publisher: BioMed Central Country of Publication: England NLM ID: 101263253 Publication Model: Electronic Cited Medium: Internet ISSN: 1745-6215 (Electronic) Linking ISSN: 17456215 NLM ISO Abbreviation: Trials Subsets: MEDLINE
Database: MEDLINE Ultimate
Description
ISSN:1745-6215
DOI:10.1186/s13063-026-09452-6