Best hypnotic drug choice for rapid sequence induction in the operating room: study protocol for a 3-arm superiority open-labeled randomized controlled trial with blinded evaluation of the primary outcome (the HyPnotiKs study).
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| Title: | Best hypnotic drug choice for rapid sequence induction in the operating room: study protocol for a 3-arm superiority open-labeled randomized controlled trial with blinded evaluation of the primary outcome (the HyPnotiKs study). |
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| Authors: | Grillot N; Université de Nantes, CHU Nantes, Pôle Anesthésie-Réanimation, Service d'Anesthésie Réanimation Chirurgicale, Hôtel Dieu, Nantes, 44093, France. nicolas.grillot@chu-nantes.fr., Volteau C; Nantes Université, CHU Nantes, Direction de la Recherche et de l'innovation, Plateforme de méthodologie et biostatistique, Nantes, 44000, France., Quillet P; Department of Clinical Research, Nantes University Hospital, Nantes, France., Ambrosi X; Université de Nantes, CHU Nantes, Anesthesia and Intensive Care Unit, Hôpital Laennec, Saint-Herblain, France., Caillard A; Anesthesia and Intensive Care Unit, Brest Regional University Hospital, Brest, France., David JS; Anesthesia and Intensive Care Unit, Lyon Sud Regional University Hospital, Hospices Civils de Lyon, Lyon, France., Blet A; Anesthesia and Intensive Care Unit, Croix Rousse University Hospital, Hospices Civils de Lyon, Lyon, France., Bouzat P; Pôle d'Anesthésie-Réanimation, Hôpital Albert Michallon, BP 217, Grenoble, 38043, France., Blanchet L; Anesthesia and Intensive Care Unit, Le Mans Public Hospital, Le Mans, France., Bruneau N; Anesthesia and Intensive Care Unit, Lille Regional University Hospital, Lille, France., Chebbi N; Service Anesthésie et Réanimation, Centre Hospitalier Louis Pasteur, Le Coudray, France., Saint-Genis Q; Anesthesia and Intensive Care Unit, Poitiers University Hospital, Poitiers, France., Figueiredo S; Anesthesia and Intensive Care Unit, Kremlin-Bicêtre University Hospital, Assistance Publique - Hôpitaux de Paris University Hospital, Le Kremlin-Bicêtre, France., Guinot PG; Anesthesia and Intensive Care Unit, Dijon University Hospital, Dijon, France., Joosten A; Department of Anesthesiology and Perioperative Medicine, Ronald Reagan UCLA Medical Center, Los Angeles, USA., Le Guen M; Anesthesia and Intensive Care Unit, Hôpital Foch, Suresnes, France., Labaste F; Anesthesia and Intensive Care Unit, Toulouse University Hospital, Toulouse, France., Lasocki S; Département Anesthésie Réanimation, CHU d'Angers, Université d'Angers, Angers, 49933, France., Oudot M; Anesthesia Unit, Vendée District Hospital Center, La Roche-Sur-Yon, France., Pommier M; Anesthesia and Intensive Care Unit, Toulouse University Hospital, Toulouse, France., Rousseleau D; CHU de Lille, Pole Anesthésie Réanimation, Hôpital Claude Huriez, Lille, France., Verdonk F; Anesthesia and Intensive Care Unit, Saint-Antoine University Hospital, Assistance Publique - Hôpitaux de Paris University Hospital, Paris, France.; Anesthesia and Intensive Care Unit, Tenon University Hospital, Assistance Publique - Hôpitaux de Paris University Hospital, Paris, France., Tching-Sin M; Department of Pharmacy, Nantes University Hospital, Nantes, France., Faurel-Paul E; Department of Clinical Research, Nantes University Hospital, Nantes, France., Counille F; Université de Nantes, CHU Nantes, Pôle Anesthésie-Réanimation, Service d'Anesthésie Réanimation Chirurgicale, Hôtel Dieu, Nantes, 44093, France., Cossé C; Université de Nantes, CHU Nantes, Pôle Anesthésie-Réanimation, Service d'Anesthésie Réanimation Chirurgicale, Hôtel Dieu, Nantes, 44093, France., Flattres Duchaussoy D; Université de Nantes, CHU Nantes, Pôle Anesthésie-Réanimation, Service d'Anesthésie Réanimation Chirurgicale, Hôtel Dieu, Nantes, 44093, France., Cinotti R; Université de Nantes, CHU Nantes, Pôle Anesthésie-Réanimation, Service d'Anesthésie Réanimation Chirurgicale, Hôtel Dieu, Nantes, 44093, France., Roquilly A; Université de Nantes, CHU Nantes, Pôle Anesthésie-Réanimation, Service d'Anesthésie Réanimation Chirurgicale, Hôtel Dieu, Nantes, 44093, France. |
| Source: | Trials [Trials] 2026 Jan 16; Vol. 27 (1), pp. 127. Date of Electronic Publication: 2026 Jan 16. |
| Publication Type: | Journal Article; Clinical Trial Protocol |
| Journal Info: | Publisher: BioMed Central Country of Publication: England NLM ID: 101263253 Publication Model: Electronic Cited Medium: Internet ISSN: 1745-6215 (Electronic) Linking ISSN: 17456215 NLM ISO Abbreviation: Trials Subsets: MEDLINE |
| Database: | MEDLINE Ultimate |
| FullText | Text: Availability: 0 |
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| Header | DbId: mdl DbLabel: MEDLINE Ultimate An: 41546091 AccessLevel: 2 PubType: Academic Journal PubTypeId: academicJournal PreciseRelevancyScore: 0 |
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| Items | – Name: Title Label: Title Group: Ti Data: Best hypnotic drug choice for rapid sequence induction in the operating room: study protocol for a 3-arm superiority open-labeled randomized controlled trial with blinded evaluation of the primary outcome (the HyPnotiKs study). – Name: Author Label: Authors Group: Au Data: <searchLink fieldCode="AU" term="%22Grillot+N%22">Grillot N</searchLink>; Université de Nantes, CHU Nantes, Pôle Anesthésie-Réanimation, Service d'Anesthésie Réanimation Chirurgicale, Hôtel Dieu, Nantes, 44093, France. nicolas.grillot@chu-nantes.fr.<br /><searchLink fieldCode="AU" term="%22Volteau+C%22">Volteau C</searchLink>; Nantes Université, CHU Nantes, Direction de la Recherche et de l'innovation, Plateforme de méthodologie et biostatistique, Nantes, 44000, France.<br /><searchLink fieldCode="AU" term="%22Quillet+P%22">Quillet P</searchLink>; Department of Clinical Research, Nantes University Hospital, Nantes, France.<br /><searchLink fieldCode="AU" term="%22Ambrosi+X%22">Ambrosi X</searchLink>; Université de Nantes, CHU Nantes, Anesthesia and Intensive Care Unit, Hôpital Laennec, Saint-Herblain, France.<br /><searchLink fieldCode="AU" term="%22Caillard+A%22">Caillard A</searchLink>; Anesthesia and Intensive Care Unit, Brest Regional University Hospital, Brest, France.<br /><searchLink fieldCode="AU" term="%22David+JS%22">David JS</searchLink>; Anesthesia and Intensive Care Unit, Lyon Sud Regional University Hospital, Hospices Civils de Lyon, Lyon, France.<br /><searchLink fieldCode="AU" term="%22Blet+A%22">Blet A</searchLink>; Anesthesia and Intensive Care Unit, Croix Rousse University Hospital, Hospices Civils de Lyon, Lyon, France.<br /><searchLink fieldCode="AU" term="%22Bouzat+P%22">Bouzat P</searchLink>; Pôle d'Anesthésie-Réanimation, Hôpital Albert Michallon, BP 217, Grenoble, 38043, France.<br /><searchLink fieldCode="AU" term="%22Blanchet+L%22">Blanchet L</searchLink>; Anesthesia and Intensive Care Unit, Le Mans Public Hospital, Le Mans, France.<br /><searchLink fieldCode="AU" term="%22Bruneau+N%22">Bruneau N</searchLink>; Anesthesia and Intensive Care Unit, Lille Regional University Hospital, Lille, France.<br /><searchLink fieldCode="AU" term="%22Chebbi+N%22">Chebbi N</searchLink>; Service Anesthésie et Réanimation, Centre Hospitalier Louis Pasteur, Le Coudray, France.<br /><searchLink fieldCode="AU" term="%22Saint-Genis+Q%22">Saint-Genis Q</searchLink>; Anesthesia and Intensive Care Unit, Poitiers University Hospital, Poitiers, France.<br /><searchLink fieldCode="AU" term="%22Figueiredo+S%22">Figueiredo S</searchLink>; Anesthesia and Intensive Care Unit, Kremlin-Bicêtre University Hospital, Assistance Publique - Hôpitaux de Paris University Hospital, Le Kremlin-Bicêtre, France.<br /><searchLink fieldCode="AU" term="%22Guinot+PG%22">Guinot PG</searchLink>; Anesthesia and Intensive Care Unit, Dijon University Hospital, Dijon, France.<br /><searchLink fieldCode="AU" term="%22Joosten+A%22">Joosten A</searchLink>; Department of Anesthesiology and Perioperative Medicine, Ronald Reagan UCLA Medical Center, Los Angeles, USA.<br /><searchLink fieldCode="AU" term="%22Le+Guen+M%22">Le Guen M</searchLink>; Anesthesia and Intensive Care Unit, Hôpital Foch, Suresnes, France.<br /><searchLink fieldCode="AU" term="%22Labaste+F%22">Labaste F</searchLink>; Anesthesia and Intensive Care Unit, Toulouse University Hospital, Toulouse, France.<br /><searchLink fieldCode="AU" term="%22Lasocki+S%22">Lasocki S</searchLink>; Département Anesthésie Réanimation, CHU d'Angers, Université d'Angers, Angers, 49933, France.<br /><searchLink fieldCode="AU" term="%22Oudot+M%22">Oudot M</searchLink>; Anesthesia Unit, Vendée District Hospital Center, La Roche-Sur-Yon, France.<br /><searchLink fieldCode="AU" term="%22Pommier+M%22">Pommier M</searchLink>; Anesthesia and Intensive Care Unit, Toulouse University Hospital, Toulouse, France.<br /><searchLink fieldCode="AU" term="%22Rousseleau+D%22">Rousseleau D</searchLink>; CHU de Lille, Pole Anesthésie Réanimation, Hôpital Claude Huriez, Lille, France.<br /><searchLink fieldCode="AU" term="%22Verdonk+F%22">Verdonk F</searchLink>; Anesthesia and Intensive Care Unit, Saint-Antoine University Hospital, Assistance Publique - Hôpitaux de Paris University Hospital, Paris, France.; Anesthesia and Intensive Care Unit, Tenon University Hospital, Assistance Publique - Hôpitaux de Paris University Hospital, Paris, France.<br /><searchLink fieldCode="AU" term="%22Tching-Sin+M%22">Tching-Sin M</searchLink>; Department of Pharmacy, Nantes University Hospital, Nantes, France.<br /><searchLink fieldCode="AU" term="%22Faurel-Paul+E%22">Faurel-Paul E</searchLink>; Department of Clinical Research, Nantes University Hospital, Nantes, France.<br /><searchLink fieldCode="AU" term="%22Counille+F%22">Counille F</searchLink>; Université de Nantes, CHU Nantes, Pôle Anesthésie-Réanimation, Service d'Anesthésie Réanimation Chirurgicale, Hôtel Dieu, Nantes, 44093, France.<br /><searchLink fieldCode="AU" term="%22Cossé+C%22">Cossé C</searchLink>; Université de Nantes, CHU Nantes, Pôle Anesthésie-Réanimation, Service d'Anesthésie Réanimation Chirurgicale, Hôtel Dieu, Nantes, 44093, France.<br /><searchLink fieldCode="AU" term="%22Flattres+Duchaussoy+D%22">Flattres Duchaussoy D</searchLink>; Université de Nantes, CHU Nantes, Pôle Anesthésie-Réanimation, Service d'Anesthésie Réanimation Chirurgicale, Hôtel Dieu, Nantes, 44093, France.<br /><searchLink fieldCode="AU" term="%22Cinotti+R%22">Cinotti R</searchLink>; Université de Nantes, CHU Nantes, Pôle Anesthésie-Réanimation, Service d'Anesthésie Réanimation Chirurgicale, Hôtel Dieu, Nantes, 44093, France.<br /><searchLink fieldCode="AU" term="%22Roquilly+A%22">Roquilly A</searchLink>; Université de Nantes, CHU Nantes, Pôle Anesthésie-Réanimation, Service d'Anesthésie Réanimation Chirurgicale, Hôtel Dieu, Nantes, 44093, France. – Name: TitleSource Label: Source Group: Src Data: <searchLink fieldCode="JN" term="%22101263253%22">Trials</searchLink> [Trials] 2026 Jan 16; Vol. 27 (1), pp. 127. <i>Date of Electronic Publication: </i>2026 Jan 16. – Name: TypePub Label: Publication Type Group: TypPub Data: Journal Article; Clinical Trial Protocol – Name: TitleSource Label: Journal Info Group: Src Data: <i>Publisher: </i><searchLink fieldCode="PB" term="%22BioMed+Central%22">BioMed Central </searchLink><i>Country of Publication: </i>England <i>NLM ID: </i>101263253 <i>Publication Model: </i>Electronic <i>Cited Medium: </i>Internet <i>ISSN: </i>1745-6215 (Electronic) <i>Linking ISSN: </i><searchLink fieldCode="IS" term="%2217456215%22">17456215 </searchLink><i>NLM ISO Abbreviation: </i>Trials <i>Subsets: </i>MEDLINE |
| PLink | https://search.ebscohost.com/login.aspx?direct=true&site=eds-live&db=mdl&AN=41546091 |
| RecordInfo | BibRecord: BibEntity: Identifiers: – Type: doi Value: 10.1186/s13063-026-09452-6 Languages: – Code: eng Text: English PhysicalDescription: Pagination: StartPage: 127 Titles: – TitleFull: Best hypnotic drug choice for rapid sequence induction in the operating room: study protocol for a 3-arm superiority open-labeled randomized controlled trial with blinded evaluation of the primary outcome (the HyPnotiKs study). Type: main BibRelationships: HasContributorRelationships: – PersonEntity: Name: NameFull: Grillot N – PersonEntity: Name: NameFull: Volteau C – PersonEntity: Name: NameFull: Quillet P – PersonEntity: Name: NameFull: Ambrosi X – PersonEntity: Name: NameFull: Caillard A – PersonEntity: Name: NameFull: David JS – PersonEntity: Name: NameFull: Blet A – PersonEntity: Name: NameFull: Bouzat P – PersonEntity: Name: NameFull: Blanchet L – PersonEntity: Name: NameFull: Bruneau N – PersonEntity: Name: NameFull: Chebbi N – PersonEntity: Name: NameFull: Saint-Genis Q – PersonEntity: Name: NameFull: Figueiredo S – PersonEntity: Name: NameFull: Guinot PG – PersonEntity: Name: NameFull: Joosten A – PersonEntity: Name: NameFull: Le Guen M – PersonEntity: Name: NameFull: Labaste F – PersonEntity: Name: NameFull: Lasocki S – PersonEntity: Name: NameFull: Oudot M – PersonEntity: Name: NameFull: Pommier M – PersonEntity: Name: NameFull: Rousseleau D – PersonEntity: Name: NameFull: Verdonk F – PersonEntity: Name: NameFull: Tching-Sin M – PersonEntity: Name: NameFull: Faurel-Paul E – PersonEntity: Name: NameFull: Counille F – PersonEntity: Name: NameFull: Cossé C – PersonEntity: Name: NameFull: Flattres Duchaussoy D – PersonEntity: Name: NameFull: Cinotti R – PersonEntity: Name: NameFull: Roquilly A IsPartOfRelationships: – BibEntity: Dates: – D: 16 M: 01 Text: 2026 Jan 16 Type: published Y: 2026 Identifiers: – Type: issn-electronic Value: 1745-6215 Numbering: – Type: volume Value: 27 – Type: issue Value: 1 Titles: – TitleFull: Trials Type: main |
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