Human genetics guides the discovery of CARD9 inhibitors with anti-inflammatory activity.

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Bibliographic Details
Title: Human genetics guides the discovery of CARD9 inhibitors with anti-inflammatory activity.
Authors: Rush JS; Center for the Development of Therapeutics, Broad Institute of MIT and Harvard, Cambridge, MA 02142, USA., Wertheimer JD; Johnson & Johnson Innovative Medicine, Spring House, PA 19477, USA., Goldberg SD; Johnson & Johnson Innovative Medicine, San Diego, CA 92121, USA., Raymond D; Center for the Development of Therapeutics, Broad Institute of MIT and Harvard, Cambridge, MA 02142, USA., Szuchnicki M; Center for the Development of Therapeutics, Broad Institute of MIT and Harvard, Cambridge, MA 02142, USA., Baltus AJ; Johnson & Johnson Innovative Medicine, Spring House, PA 19477, USA., Branson J; Johnson & Johnson Innovative Medicine, Spring House, PA 19477, USA., Stratton CF; Johnson & Johnson Innovative Medicine, Spring House, PA 19477, USA., Patrick AN; Johnson & Johnson Innovative Medicine, Spring House, PA 19477, USA., Steele R; Johnson & Johnson Innovative Medicine, Spring House, PA 19477, USA., Adhikary S; Johnson & Johnson Innovative Medicine, Spring House, PA 19477, USA., Del Rosario A; Johnson & Johnson Innovative Medicine, Spring House, PA 19477, USA., Liu A; Johnson & Johnson Innovative Medicine, Spring House, PA 19477, USA., Gomersall NJ; Johnson & Johnson Innovative Medicine, Spring House, PA 19477, USA., Chung M; Johnson & Johnson Innovative Medicine, San Diego, CA 92121, USA., Ranaghan MJ; Center for the Development of Therapeutics, Broad Institute of MIT and Harvard, Cambridge, MA 02142, USA., Gu X; Center for Computational and Integrative Biology, Massachusetts General Hospital and Harvard Medical School, Boston, MA 02114, USA; Department of Molecular Biology, Massachusetts General Hospital and Harvard Medical School, Boston, MA 02114, USA., Brandt M; Center for the Development of Therapeutics, Broad Institute of MIT and Harvard, Cambridge, MA 02142, USA; Center for Computational and Integrative Biology, Massachusetts General Hospital and Harvard Medical School, Boston, MA 02114, USA; Department of Molecular Biology, Massachusetts General Hospital and Harvard Medical School, Boston, MA 02114, USA., Cao Z; Center for the Development of Therapeutics, Broad Institute of MIT and Harvard, Cambridge, MA 02142, USA; Center for Computational and Integrative Biology, Massachusetts General Hospital and Harvard Medical School, Boston, MA 02114, USA; Department of Molecular Biology, Massachusetts General Hospital and Harvard Medical School, Boston, MA 02114, USA., Bebenek A; Center for the Development of Therapeutics, Broad Institute of MIT and Harvard, Cambridge, MA 02142, USA; Department of Chemistry and Chemical Biology, Harvard University, Cambridge, MA 02138, USA; Chemical Biology PhD Program, Harvard Medical School, Boston, MA 02115, USA., Oliver BA; Center for Computational and Integrative Biology, Massachusetts General Hospital and Harvard Medical School, Boston, MA 02114, USA; Department of Molecular Biology, Massachusetts General Hospital and Harvard Medical School, Boston, MA 02114, USA., Hoebe K; Johnson & Johnson Innovative Medicine, Spring House, PA 19477, USA., Szewczuk LM; Johnson & Johnson Innovative Medicine, Spring House, PA 19477, USA., Venable JD; Johnson & Johnson Innovative Medicine, San Diego, CA 92121, USA., Graham DB; Center for Computational and Integrative Biology, Massachusetts General Hospital and Harvard Medical School, Boston, MA 02114, USA; Department of Molecular Biology, Massachusetts General Hospital and Harvard Medical School, Boston, MA 02114, USA; Klarman Cell Observatory, Broad Institute of MIT and Harvard, Cambridge, MA 02142, USA., Towne J; Johnson & Johnson Innovative Medicine, San Diego, CA 92121, USA., Xavier RJ; Center for Computational and Integrative Biology, Massachusetts General Hospital and Harvard Medical School, Boston, MA 02114, USA; Department of Molecular Biology, Massachusetts General Hospital and Harvard Medical School, Boston, MA 02114, USA; Klarman Cell Observatory, Broad Institute of MIT and Harvard, Cambridge, MA 02142, USA. Electronic address: rxavier@broadinstitute.org.
Source: Cell [Cell] 2026 Mar 05; Vol. 189 (5), pp. 1356-1370.e26. Date of Electronic Publication: 2026 Jan 16.
Publication Type: Journal Article
Journal Info: Publisher: Cell Press Country of Publication: United States NLM ID: 0413066 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1097-4172 (Electronic) Linking ISSN: 00928674 NLM ISO Abbreviation: Cell Subsets: MEDLINE
Database: MEDLINE Ultimate
Description
ISSN:1097-4172
DOI:10.1016/j.cell.2025.12.013