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Human genetics guides the discovery of CARD9 inhibitors with anti-inflammatory activity.

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Title: Human genetics guides the discovery of CARD9 inhibitors with anti-inflammatory activity.
Authors: Rush JS; Center for the Development of Therapeutics, Broad Institute of MIT and Harvard, Cambridge, MA 02142, USA., Wertheimer JD; Johnson & Johnson Innovative Medicine, Spring House, PA 19477, USA., Goldberg SD; Johnson & Johnson Innovative Medicine, San Diego, CA 92121, USA., Raymond D; Center for the Development of Therapeutics, Broad Institute of MIT and Harvard, Cambridge, MA 02142, USA., Szuchnicki M; Center for the Development of Therapeutics, Broad Institute of MIT and Harvard, Cambridge, MA 02142, USA., Baltus AJ; Johnson & Johnson Innovative Medicine, Spring House, PA 19477, USA., Branson J; Johnson & Johnson Innovative Medicine, Spring House, PA 19477, USA., Stratton CF; Johnson & Johnson Innovative Medicine, Spring House, PA 19477, USA., Patrick AN; Johnson & Johnson Innovative Medicine, Spring House, PA 19477, USA., Steele R; Johnson & Johnson Innovative Medicine, Spring House, PA 19477, USA., Adhikary S; Johnson & Johnson Innovative Medicine, Spring House, PA 19477, USA., Del Rosario A; Johnson & Johnson Innovative Medicine, Spring House, PA 19477, USA., Liu A; Johnson & Johnson Innovative Medicine, Spring House, PA 19477, USA., Gomersall NJ; Johnson & Johnson Innovative Medicine, Spring House, PA 19477, USA., Chung M; Johnson & Johnson Innovative Medicine, San Diego, CA 92121, USA., Ranaghan MJ; Center for the Development of Therapeutics, Broad Institute of MIT and Harvard, Cambridge, MA 02142, USA., Gu X; Center for Computational and Integrative Biology, Massachusetts General Hospital and Harvard Medical School, Boston, MA 02114, USA; Department of Molecular Biology, Massachusetts General Hospital and Harvard Medical School, Boston, MA 02114, USA., Brandt M; Center for the Development of Therapeutics, Broad Institute of MIT and Harvard, Cambridge, MA 02142, USA; Center for Computational and Integrative Biology, Massachusetts General Hospital and Harvard Medical School, Boston, MA 02114, USA; Department of Molecular Biology, Massachusetts General Hospital and Harvard Medical School, Boston, MA 02114, USA., Cao Z; Center for the Development of Therapeutics, Broad Institute of MIT and Harvard, Cambridge, MA 02142, USA; Center for Computational and Integrative Biology, Massachusetts General Hospital and Harvard Medical School, Boston, MA 02114, USA; Department of Molecular Biology, Massachusetts General Hospital and Harvard Medical School, Boston, MA 02114, USA., Bebenek A; Center for the Development of Therapeutics, Broad Institute of MIT and Harvard, Cambridge, MA 02142, USA; Department of Chemistry and Chemical Biology, Harvard University, Cambridge, MA 02138, USA; Chemical Biology PhD Program, Harvard Medical School, Boston, MA 02115, USA., Oliver BA; Center for Computational and Integrative Biology, Massachusetts General Hospital and Harvard Medical School, Boston, MA 02114, USA; Department of Molecular Biology, Massachusetts General Hospital and Harvard Medical School, Boston, MA 02114, USA., Hoebe K; Johnson & Johnson Innovative Medicine, Spring House, PA 19477, USA., Szewczuk LM; Johnson & Johnson Innovative Medicine, Spring House, PA 19477, USA., Venable JD; Johnson & Johnson Innovative Medicine, San Diego, CA 92121, USA., Graham DB; Center for Computational and Integrative Biology, Massachusetts General Hospital and Harvard Medical School, Boston, MA 02114, USA; Department of Molecular Biology, Massachusetts General Hospital and Harvard Medical School, Boston, MA 02114, USA; Klarman Cell Observatory, Broad Institute of MIT and Harvard, Cambridge, MA 02142, USA., Towne J; Johnson & Johnson Innovative Medicine, San Diego, CA 92121, USA., Xavier RJ; Center for Computational and Integrative Biology, Massachusetts General Hospital and Harvard Medical School, Boston, MA 02114, USA; Department of Molecular Biology, Massachusetts General Hospital and Harvard Medical School, Boston, MA 02114, USA; Klarman Cell Observatory, Broad Institute of MIT and Harvard, Cambridge, MA 02142, USA. Electronic address: rxavier@broadinstitute.org.
Source: Cell [Cell] 2026 Mar 05; Vol. 189 (5), pp. 1356-1370.e26. Date of Electronic Publication: 2026 Jan 16.
Publication Type: Journal Article
Journal Info: Publisher: Cell Press Country of Publication: United States NLM ID: 0413066 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1097-4172 (Electronic) Linking ISSN: 00928674 NLM ISO Abbreviation: Cell Subsets: MEDLINE
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  Data: <searchLink fieldCode="AU" term="%22Rush+JS%22">Rush JS</searchLink>; Center for the Development of Therapeutics, Broad Institute of MIT and Harvard, Cambridge, MA 02142, USA.<br /><searchLink fieldCode="AU" term="%22Wertheimer+JD%22">Wertheimer JD</searchLink>; Johnson & Johnson Innovative Medicine, Spring House, PA 19477, USA.<br /><searchLink fieldCode="AU" term="%22Goldberg+SD%22">Goldberg SD</searchLink>; Johnson & Johnson Innovative Medicine, San Diego, CA 92121, USA.<br /><searchLink fieldCode="AU" term="%22Raymond+D%22">Raymond D</searchLink>; Center for the Development of Therapeutics, Broad Institute of MIT and Harvard, Cambridge, MA 02142, USA.<br /><searchLink fieldCode="AU" term="%22Szuchnicki+M%22">Szuchnicki M</searchLink>; Center for the Development of Therapeutics, Broad Institute of MIT and Harvard, Cambridge, MA 02142, USA.<br /><searchLink fieldCode="AU" term="%22Baltus+AJ%22">Baltus AJ</searchLink>; Johnson & Johnson Innovative Medicine, Spring House, PA 19477, USA.<br /><searchLink fieldCode="AU" term="%22Branson+J%22">Branson J</searchLink>; Johnson & Johnson Innovative Medicine, Spring House, PA 19477, USA.<br /><searchLink fieldCode="AU" term="%22Stratton+CF%22">Stratton CF</searchLink>; Johnson & Johnson Innovative Medicine, Spring House, PA 19477, USA.<br /><searchLink fieldCode="AU" term="%22Patrick+AN%22">Patrick AN</searchLink>; Johnson & Johnson Innovative Medicine, Spring House, PA 19477, USA.<br /><searchLink fieldCode="AU" term="%22Steele+R%22">Steele R</searchLink>; Johnson & Johnson Innovative Medicine, Spring House, PA 19477, USA.<br /><searchLink fieldCode="AU" term="%22Adhikary+S%22">Adhikary S</searchLink>; Johnson & Johnson Innovative Medicine, Spring House, PA 19477, USA.<br /><searchLink fieldCode="AU" term="%22Del+Rosario+A%22">Del Rosario A</searchLink>; Johnson & Johnson Innovative Medicine, Spring House, PA 19477, USA.<br /><searchLink fieldCode="AU" term="%22Liu+A%22">Liu A</searchLink>; Johnson & Johnson Innovative Medicine, Spring House, PA 19477, USA.<br /><searchLink fieldCode="AU" term="%22Gomersall+NJ%22">Gomersall NJ</searchLink>; Johnson & Johnson Innovative Medicine, Spring House, PA 19477, USA.<br /><searchLink fieldCode="AU" term="%22Chung+M%22">Chung M</searchLink>; Johnson & Johnson Innovative Medicine, San Diego, CA 92121, USA.<br /><searchLink fieldCode="AU" term="%22Ranaghan+MJ%22">Ranaghan MJ</searchLink>; Center for the Development of Therapeutics, Broad Institute of MIT and Harvard, Cambridge, MA 02142, USA.<br /><searchLink fieldCode="AU" term="%22Gu+X%22">Gu X</searchLink>; Center for Computational and Integrative Biology, Massachusetts General Hospital and Harvard Medical School, Boston, MA 02114, USA; Department of Molecular Biology, Massachusetts General Hospital and Harvard Medical School, Boston, MA 02114, USA.<br /><searchLink fieldCode="AU" term="%22Brandt+M%22">Brandt M</searchLink>; Center for the Development of Therapeutics, Broad Institute of MIT and Harvard, Cambridge, MA 02142, USA; Center for Computational and Integrative Biology, Massachusetts General Hospital and Harvard Medical School, Boston, MA 02114, USA; Department of Molecular Biology, Massachusetts General Hospital and Harvard Medical School, Boston, MA 02114, USA.<br /><searchLink fieldCode="AU" term="%22Cao+Z%22">Cao Z</searchLink>; Center for the Development of Therapeutics, Broad Institute of MIT and Harvard, Cambridge, MA 02142, USA; Center for Computational and Integrative Biology, Massachusetts General Hospital and Harvard Medical School, Boston, MA 02114, USA; Department of Molecular Biology, Massachusetts General Hospital and Harvard Medical School, Boston, MA 02114, USA.<br /><searchLink fieldCode="AU" term="%22Bebenek+A%22">Bebenek A</searchLink>; Center for the Development of Therapeutics, Broad Institute of MIT and Harvard, Cambridge, MA 02142, USA; Department of Chemistry and Chemical Biology, Harvard University, Cambridge, MA 02138, USA; Chemical Biology PhD Program, Harvard Medical School, Boston, MA 02115, USA.<br /><searchLink fieldCode="AU" term="%22Oliver+BA%22">Oliver BA</searchLink>; Center for Computational and Integrative Biology, Massachusetts General Hospital and Harvard Medical School, Boston, MA 02114, USA; Department of Molecular Biology, Massachusetts General Hospital and Harvard Medical School, Boston, MA 02114, USA.<br /><searchLink fieldCode="AU" term="%22Hoebe+K%22">Hoebe K</searchLink>; Johnson & Johnson Innovative Medicine, Spring House, PA 19477, USA.<br /><searchLink fieldCode="AU" term="%22Szewczuk+LM%22">Szewczuk LM</searchLink>; Johnson & Johnson Innovative Medicine, Spring House, PA 19477, USA.<br /><searchLink fieldCode="AU" term="%22Venable+JD%22">Venable JD</searchLink>; Johnson & Johnson Innovative Medicine, San Diego, CA 92121, USA.<br /><searchLink fieldCode="AU" term="%22Graham+DB%22">Graham DB</searchLink>; Center for Computational and Integrative Biology, Massachusetts General Hospital and Harvard Medical School, Boston, MA 02114, USA; Department of Molecular Biology, Massachusetts General Hospital and Harvard Medical School, Boston, MA 02114, USA; Klarman Cell Observatory, Broad Institute of MIT and Harvard, Cambridge, MA 02142, USA.<br /><searchLink fieldCode="AU" term="%22Towne+J%22">Towne J</searchLink>; Johnson & Johnson Innovative Medicine, San Diego, CA 92121, USA.<br /><searchLink fieldCode="AU" term="%22Xavier+RJ%22">Xavier RJ</searchLink>; Center for Computational and Integrative Biology, Massachusetts General Hospital and Harvard Medical School, Boston, MA 02114, USA; Department of Molecular Biology, Massachusetts General Hospital and Harvard Medical School, Boston, MA 02114, USA; Klarman Cell Observatory, Broad Institute of MIT and Harvard, Cambridge, MA 02142, USA. Electronic address: rxavier@broadinstitute.org.
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  Data: <searchLink fieldCode="JN" term="%220413066%22">Cell</searchLink> [Cell] 2026 Mar 05; Vol. 189 (5), pp. 1356-1370.e26. <i>Date of Electronic Publication: </i>2026 Jan 16.
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