Inhibition of CDK8 rescues impaired ischemic fracture healing.
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| Title: | Inhibition of CDK8 rescues impaired ischemic fracture healing. |
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| Authors: | Capobianco CA; Department of Orthopaedic Surgery, University of Michigan, Ann Arbor, MI, USA.; Department of Biomedical Engineering, University of Michigan, Ann Arbor, MI, USA., Song MJ; Department of Orthopaedic Surgery, University of Michigan, Ann Arbor, MI, USA.; Department of Biomedical Engineering, University of Michigan, Ann Arbor, MI, USA., Farrell EC; Department of Orthopaedic Surgery, University of Michigan, Ann Arbor, MI, USA.; Department of Biomedical Engineering, University of Michigan, Ann Arbor, MI, USA., Knights AJ; Department of Orthopaedic Surgery, University of Michigan, Ann Arbor, MI, USA., Kessell K; Department of Orthopaedic Surgery, University of Michigan, Ann Arbor, MI, USA., Donneys A; Department of Orthopaedic Surgery, University of Michigan, Ann Arbor, MI, USA., Schmanski JT; Department of Orthopaedic Surgery, University of Michigan, Ann Arbor, MI, USA.; Department of Biomedical Engineering, University of Michigan, Ann Arbor, MI, USA., Schroeder LR; Department of Orthopaedic Surgery, University of Michigan, Ann Arbor, MI, USA.; Department of Biomedical Engineering, University of Michigan, Ann Arbor, MI, USA., Chen M; Department of Drug Discovery and Biomedical Sciences, University of South Carolina, Columbia, SC, USA.; Senex Biotechnology Inc., Columbia, SC, USA., Roninson IB; Department of Drug Discovery and Biomedical Sciences, University of South Carolina, Columbia, SC, USA.; Senex Biotechnology Inc., Columbia, SC, USA., Wagley Y; Department of Orthopaedic Surgery, University of Michigan, Ann Arbor, MI, USA., Maerz T; Department of Orthopaedic Surgery, University of Michigan, Ann Arbor, MI, USA. maerzt@ethz.ch.; Department of Biomedical Engineering, University of Michigan, Ann Arbor, MI, USA. maerzt@ethz.ch.; Division of Rheumatology, Department of Internal Medicine, University of Michigan, Ann Arbor, MI, USA. maerzt@ethz.ch.; Institute for Biomechanics, Department of Health Sciences and Technology, ETH Zurich, Zurich, Switzerland. maerzt@ethz.ch., Hankenson KD; Department of Orthopaedic Surgery, University of Michigan, Ann Arbor, MI, USA. kdhank@umich.edu.; Department of Biomedical Engineering, University of Michigan, Ann Arbor, MI, USA. kdhank@umich.edu.; Department of Molecular and Integrative Physiology, University of Michigan, Ann Arbor, MI, USA. kdhank@umich.edu. |
| Source: | NPJ Regenerative medicine [NPJ Regen Med] 2026 Jan 17; Vol. 11 (1), pp. 12. Date of Electronic Publication: 2026 Jan 17. |
| Publication Type: | Journal Article |
| Journal Info: | Publisher: Nature Publishing Group, published in partnership with Monash University and Australian Regenerative Medicine Institute Country of Publication: United States NLM ID: 101699846 Publication Model: Electronic Cited Medium: Internet ISSN: 2057-3995 (Electronic) Linking ISSN: 20573995 NLM ISO Abbreviation: NPJ Regen Med Subsets: PubMed not MEDLINE |
| Database: | MEDLINE Ultimate |
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| ISSN: | 2057-3995 |
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| DOI: | 10.1038/s41536-026-00456-z |
