View in EDS HTML Full Text PDF Full Text

BCOR mutations define a therapeutic vulnerability to DHODH Inhibition in acute myeloid leukemia.

Saved in:
Bibliographic Details
Title: BCOR mutations define a therapeutic vulnerability to DHODH Inhibition in acute myeloid leukemia.
Authors: Robert F; Department of Medical Genetics, Level 6 Addenbrooke's Treatment Centre, Cambridge Biomedical Research Campus, Box 238, Cambridge , CB2 0QQ, UK. fr392@cam.ac.uk.; Early Cancer Institute, Department of Oncology, Cambridge Biomedical Research Campus, Hutchison Research Centre, Box 197, Cambridge, CB2 0XZ, UK. fr392@cam.ac.uk., Badja C; Department of Medical Genetics, Level 6 Addenbrooke's Treatment Centre, Cambridge Biomedical Research Campus, Box 238, Cambridge , CB2 0QQ, UK.; Early Cancer Institute, Department of Oncology, Cambridge Biomedical Research Campus, Hutchison Research Centre, Box 197, Cambridge, CB2 0XZ, UK., Boushaki S; Department of Medical Genetics, Level 6 Addenbrooke's Treatment Centre, Cambridge Biomedical Research Campus, Box 238, Cambridge , CB2 0QQ, UK.; Early Cancer Institute, Department of Oncology, Cambridge Biomedical Research Campus, Hutchison Research Centre, Box 197, Cambridge, CB2 0XZ, UK., Degasperi A; Department of Medical Genetics, Level 6 Addenbrooke's Treatment Centre, Cambridge Biomedical Research Campus, Box 238, Cambridge , CB2 0QQ, UK.; Early Cancer Institute, Department of Oncology, Cambridge Biomedical Research Campus, Hutchison Research Centre, Box 197, Cambridge, CB2 0XZ, UK., Memari Y; Department of Medical Genetics, Level 6 Addenbrooke's Treatment Centre, Cambridge Biomedical Research Campus, Box 238, Cambridge , CB2 0QQ, UK.; Early Cancer Institute, Department of Oncology, Cambridge Biomedical Research Campus, Hutchison Research Centre, Box 197, Cambridge, CB2 0XZ, UK., Momen S; Department of Medical Genetics, Level 6 Addenbrooke's Treatment Centre, Cambridge Biomedical Research Campus, Box 238, Cambridge , CB2 0QQ, UK.; Early Cancer Institute, Department of Oncology, Cambridge Biomedical Research Campus, Hutchison Research Centre, Box 197, Cambridge, CB2 0XZ, UK., Roumeliotis TI; Functional Proteomics Group, Institute of Cancer Research, Chester Betty Labs, London, SW3 6JB, UK., Kozik Z; Functional Proteomics Group, Institute of Cancer Research, Chester Betty Labs, London, SW3 6JB, UK., Gozdecka M; Cambridge Stem Cell Institute, Jeffrey Cheah Biomedical Centre, Puddicombe Way, Cambridge, CB2 0AW, UK., Choudhary J; Functional Proteomics Group, Institute of Cancer Research, Chester Betty Labs, London, SW3 6JB, UK., Vassiliou G; Cambridge Stem Cell Institute, Jeffrey Cheah Biomedical Centre, Puddicombe Way, Cambridge, CB2 0AW, UK., Koh GC; Department of Medical Genetics, Level 6 Addenbrooke's Treatment Centre, Cambridge Biomedical Research Campus, Box 238, Cambridge , CB2 0QQ, UK.; Early Cancer Institute, Department of Oncology, Cambridge Biomedical Research Campus, Hutchison Research Centre, Box 197, Cambridge, CB2 0XZ, UK., Nik-Zainal S; Department of Medical Genetics, Level 6 Addenbrooke's Treatment Centre, Cambridge Biomedical Research Campus, Box 238, Cambridge , CB2 0QQ, UK.; Early Cancer Institute, Department of Oncology, Cambridge Biomedical Research Campus, Hutchison Research Centre, Box 197, Cambridge, CB2 0XZ, UK.
Source: Annals of hematology [Ann Hematol] 2026 Jan 19; Vol. 105 (1), pp. 32. Date of Electronic Publication: 2026 Jan 19.
Publication Type: Journal Article
Journal Info: Publisher: Springer Verlag Country of Publication: Germany NLM ID: 9107334 Publication Model: Electronic Cited Medium: Internet ISSN: 1432-0584 (Electronic) Linking ISSN: 09395555 NLM ISO Abbreviation: Ann Hematol Subsets: MEDLINE
Database: MEDLINE Ultimate
Full text is not displayed to guests.
FullText Links:
  – Type: pdflink
Text:
  Availability: 1
Header DbId: mdl
DbLabel: MEDLINE Ultimate
An: 41549155
AccessLevel: 2
PubType: Academic Journal
PubTypeId: academicJournal
PreciseRelevancyScore: 0
IllustrationInfo
Items – Name: Title
  Label: Title
  Group: Ti
  Data: BCOR mutations define a therapeutic vulnerability to DHODH Inhibition in acute myeloid leukemia.
– Name: Author
  Label: Authors
  Group: Au
  Data: <searchLink fieldCode="AU" term="%22Robert+F%22">Robert F</searchLink>; Department of Medical Genetics, Level 6 Addenbrooke's Treatment Centre, Cambridge Biomedical Research Campus, Box 238, Cambridge , CB2 0QQ, UK. fr392@cam.ac.uk.; Early Cancer Institute, Department of Oncology, Cambridge Biomedical Research Campus, Hutchison Research Centre, Box 197, Cambridge, CB2 0XZ, UK. fr392@cam.ac.uk.<br /><searchLink fieldCode="AU" term="%22Badja+C%22">Badja C</searchLink>; Department of Medical Genetics, Level 6 Addenbrooke's Treatment Centre, Cambridge Biomedical Research Campus, Box 238, Cambridge , CB2 0QQ, UK.; Early Cancer Institute, Department of Oncology, Cambridge Biomedical Research Campus, Hutchison Research Centre, Box 197, Cambridge, CB2 0XZ, UK.<br /><searchLink fieldCode="AU" term="%22Boushaki+S%22">Boushaki S</searchLink>; Department of Medical Genetics, Level 6 Addenbrooke's Treatment Centre, Cambridge Biomedical Research Campus, Box 238, Cambridge , CB2 0QQ, UK.; Early Cancer Institute, Department of Oncology, Cambridge Biomedical Research Campus, Hutchison Research Centre, Box 197, Cambridge, CB2 0XZ, UK.<br /><searchLink fieldCode="AU" term="%22Degasperi+A%22">Degasperi A</searchLink>; Department of Medical Genetics, Level 6 Addenbrooke's Treatment Centre, Cambridge Biomedical Research Campus, Box 238, Cambridge , CB2 0QQ, UK.; Early Cancer Institute, Department of Oncology, Cambridge Biomedical Research Campus, Hutchison Research Centre, Box 197, Cambridge, CB2 0XZ, UK.<br /><searchLink fieldCode="AU" term="%22Memari+Y%22">Memari Y</searchLink>; Department of Medical Genetics, Level 6 Addenbrooke's Treatment Centre, Cambridge Biomedical Research Campus, Box 238, Cambridge , CB2 0QQ, UK.; Early Cancer Institute, Department of Oncology, Cambridge Biomedical Research Campus, Hutchison Research Centre, Box 197, Cambridge, CB2 0XZ, UK.<br /><searchLink fieldCode="AU" term="%22Momen+S%22">Momen S</searchLink>; Department of Medical Genetics, Level 6 Addenbrooke's Treatment Centre, Cambridge Biomedical Research Campus, Box 238, Cambridge , CB2 0QQ, UK.; Early Cancer Institute, Department of Oncology, Cambridge Biomedical Research Campus, Hutchison Research Centre, Box 197, Cambridge, CB2 0XZ, UK.<br /><searchLink fieldCode="AU" term="%22Roumeliotis+TI%22">Roumeliotis TI</searchLink>; Functional Proteomics Group, Institute of Cancer Research, Chester Betty Labs, London, SW3 6JB, UK.<br /><searchLink fieldCode="AU" term="%22Kozik+Z%22">Kozik Z</searchLink>; Functional Proteomics Group, Institute of Cancer Research, Chester Betty Labs, London, SW3 6JB, UK.<br /><searchLink fieldCode="AU" term="%22Gozdecka+M%22">Gozdecka M</searchLink>; Cambridge Stem Cell Institute, Jeffrey Cheah Biomedical Centre, Puddicombe Way, Cambridge, CB2 0AW, UK.<br /><searchLink fieldCode="AU" term="%22Choudhary+J%22">Choudhary J</searchLink>; Functional Proteomics Group, Institute of Cancer Research, Chester Betty Labs, London, SW3 6JB, UK.<br /><searchLink fieldCode="AU" term="%22Vassiliou+G%22">Vassiliou G</searchLink>; Cambridge Stem Cell Institute, Jeffrey Cheah Biomedical Centre, Puddicombe Way, Cambridge, CB2 0AW, UK.<br /><searchLink fieldCode="AU" term="%22Koh+GC%22">Koh GC</searchLink>; Department of Medical Genetics, Level 6 Addenbrooke's Treatment Centre, Cambridge Biomedical Research Campus, Box 238, Cambridge , CB2 0QQ, UK.; Early Cancer Institute, Department of Oncology, Cambridge Biomedical Research Campus, Hutchison Research Centre, Box 197, Cambridge, CB2 0XZ, UK.<br /><searchLink fieldCode="AU" term="%22Nik-Zainal+S%22">Nik-Zainal S</searchLink>; Department of Medical Genetics, Level 6 Addenbrooke's Treatment Centre, Cambridge Biomedical Research Campus, Box 238, Cambridge , CB2 0QQ, UK.; Early Cancer Institute, Department of Oncology, Cambridge Biomedical Research Campus, Hutchison Research Centre, Box 197, Cambridge, CB2 0XZ, UK.
– Name: TitleSource
  Label: Source
  Group: Src
  Data: <searchLink fieldCode="JN" term="%229107334%22">Annals of hematology</searchLink> [Ann Hematol] 2026 Jan 19; Vol. 105 (1), pp. 32. <i>Date of Electronic Publication: </i>2026 Jan 19.
– Name: TypePub
  Label: Publication Type
  Group: TypPub
  Data: Journal Article
– Name: TitleSource
  Label: Journal Info
  Group: Src
  Data: <i>Publisher: </i><searchLink fieldCode="PB" term="%22Springer+Verlag%22">Springer Verlag </searchLink><i>Country of Publication: </i>Germany <i>NLM ID: </i>9107334 <i>Publication Model: </i>Electronic <i>Cited Medium: </i>Internet <i>ISSN: </i>1432-0584 (Electronic) <i>Linking ISSN: </i><searchLink fieldCode="IS" term="%2209395555%22">09395555 </searchLink><i>NLM ISO Abbreviation: </i>Ann Hematol <i>Subsets: </i>MEDLINE
PLink https://search.ebscohost.com/login.aspx?direct=true&site=eds-live&db=mdl&AN=41549155
RecordInfo BibRecord:
  BibEntity:
    Identifiers:
      – Type: doi
        Value: 10.1007/s00277-026-06773-z
    Languages:
      – Code: eng
        Text: English
    PhysicalDescription:
      Pagination:
        StartPage: 32
    Titles:
      – TitleFull: BCOR mutations define a therapeutic vulnerability to DHODH Inhibition in acute myeloid leukemia.
        Type: main
  BibRelationships:
    HasContributorRelationships:
      – PersonEntity:
          Name:
            NameFull: Robert F
      – PersonEntity:
          Name:
            NameFull: Badja C
      – PersonEntity:
          Name:
            NameFull: Boushaki S
      – PersonEntity:
          Name:
            NameFull: Degasperi A
      – PersonEntity:
          Name:
            NameFull: Memari Y
      – PersonEntity:
          Name:
            NameFull: Momen S
      – PersonEntity:
          Name:
            NameFull: Roumeliotis TI
      – PersonEntity:
          Name:
            NameFull: Kozik Z
      – PersonEntity:
          Name:
            NameFull: Gozdecka M
      – PersonEntity:
          Name:
            NameFull: Choudhary J
      – PersonEntity:
          Name:
            NameFull: Vassiliou G
      – PersonEntity:
          Name:
            NameFull: Koh GC
      – PersonEntity:
          Name:
            NameFull: Nik-Zainal S
    IsPartOfRelationships:
      – BibEntity:
          Dates:
            – D: 19
              M: 01
              Text: 2026 Jan 19
              Type: published
              Y: 2026
          Identifiers:
            – Type: issn-electronic
              Value: 1432-0584
          Numbering:
            – Type: volume
              Value: 105
            – Type: issue
              Value: 1
          Titles:
            – TitleFull: Annals of hematology
              Type: main
ResultId 1