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Lopinavir Derivative as Potent P-gp Inhibitor Enables Delivery through HPMA Copolymer Conjugates and Overcoming Tumor Chemoresistance to Conventional Cytostatic Drugs.

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Bibliographic Details
Title: Lopinavir Derivative as Potent P-gp Inhibitor Enables Delivery through HPMA Copolymer Conjugates and Overcoming Tumor Chemoresistance to Conventional Cytostatic Drugs.
Authors: Starenko D; Institute of Microbiology of the Czech Academy of Sciences, Videnska 1083, Prague 142 00, Czech Republic., Kostka L; Institute of Macromolecular Chemistry of the Czech Academy of Sciences, Heyrovskeho namesti 1888, Prague 162 00, Czech Republic., Behalova K; Institute of Microbiology of the Czech Academy of Sciences, Videnska 1083, Prague 142 00, Czech Republic., Kotrchova L; Institute of Macromolecular Chemistry of the Czech Academy of Sciences, Heyrovskeho namesti 1888, Prague 162 00, Czech Republic., Subr V; Institute of Macromolecular Chemistry of the Czech Academy of Sciences, Heyrovskeho namesti 1888, Prague 162 00, Czech Republic., Kovarova J; Institute of Microbiology of the Czech Academy of Sciences, Videnska 1083, Prague 142 00, Czech Republic., Roubalova R; Institute of Microbiology of the Czech Academy of Sciences, Videnska 1083, Prague 142 00, Czech Republic., Sirova M; Institute of Microbiology of the Czech Academy of Sciences, Videnska 1083, Prague 142 00, Czech Republic., Etrych T; Institute of Macromolecular Chemistry of the Czech Academy of Sciences, Heyrovskeho namesti 1888, Prague 162 00, Czech Republic., Kovar M; Institute of Microbiology of the Czech Academy of Sciences, Videnska 1083, Prague 142 00, Czech Republic.
Source: Biomacromolecules [Biomacromolecules] 2026 Feb 09; Vol. 27 (2), pp. 1510-1524. Date of Electronic Publication: 2026 Jan 19.
Publication Type: Journal Article
Journal Info: Publisher: American Chemical Society Country of Publication: United States NLM ID: 100892849 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1526-4602 (Electronic) Linking ISSN: 15257797 NLM ISO Abbreviation: Biomacromolecules Subsets: MEDLINE
Database: MEDLINE Ultimate
Description
ISSN:1526-4602
DOI:10.1021/acs.biomac.5c02097