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Lopinavir Derivative as Potent P-gp Inhibitor Enables Delivery through HPMA Copolymer Conjugates and Overcoming Tumor Chemoresistance to Conventional Cytostatic Drugs.

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Title: Lopinavir Derivative as Potent P-gp Inhibitor Enables Delivery through HPMA Copolymer Conjugates and Overcoming Tumor Chemoresistance to Conventional Cytostatic Drugs.
Authors: Starenko D; Institute of Microbiology of the Czech Academy of Sciences, Videnska 1083, Prague 142 00, Czech Republic., Kostka L; Institute of Macromolecular Chemistry of the Czech Academy of Sciences, Heyrovskeho namesti 1888, Prague 162 00, Czech Republic., Behalova K; Institute of Microbiology of the Czech Academy of Sciences, Videnska 1083, Prague 142 00, Czech Republic., Kotrchova L; Institute of Macromolecular Chemistry of the Czech Academy of Sciences, Heyrovskeho namesti 1888, Prague 162 00, Czech Republic., Subr V; Institute of Macromolecular Chemistry of the Czech Academy of Sciences, Heyrovskeho namesti 1888, Prague 162 00, Czech Republic., Kovarova J; Institute of Microbiology of the Czech Academy of Sciences, Videnska 1083, Prague 142 00, Czech Republic., Roubalova R; Institute of Microbiology of the Czech Academy of Sciences, Videnska 1083, Prague 142 00, Czech Republic., Sirova M; Institute of Microbiology of the Czech Academy of Sciences, Videnska 1083, Prague 142 00, Czech Republic., Etrych T; Institute of Macromolecular Chemistry of the Czech Academy of Sciences, Heyrovskeho namesti 1888, Prague 162 00, Czech Republic., Kovar M; Institute of Microbiology of the Czech Academy of Sciences, Videnska 1083, Prague 142 00, Czech Republic.
Source: Biomacromolecules [Biomacromolecules] 2026 Feb 09; Vol. 27 (2), pp. 1510-1524. Date of Electronic Publication: 2026 Jan 19.
Publication Type: Journal Article
Journal Info: Publisher: American Chemical Society Country of Publication: United States NLM ID: 100892849 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1526-4602 (Electronic) Linking ISSN: 15257797 NLM ISO Abbreviation: Biomacromolecules Subsets: MEDLINE
Database: MEDLINE Ultimate
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  Data: <searchLink fieldCode="AU" term="%22Starenko+D%22">Starenko D</searchLink>; Institute of Microbiology of the Czech Academy of Sciences, Videnska 1083, Prague 142 00, Czech Republic.<br /><searchLink fieldCode="AU" term="%22Kostka+L%22">Kostka L</searchLink>; Institute of Macromolecular Chemistry of the Czech Academy of Sciences, Heyrovskeho namesti 1888, Prague 162 00, Czech Republic.<br /><searchLink fieldCode="AU" term="%22Behalova+K%22">Behalova K</searchLink>; Institute of Microbiology of the Czech Academy of Sciences, Videnska 1083, Prague 142 00, Czech Republic.<br /><searchLink fieldCode="AU" term="%22Kotrchova+L%22">Kotrchova L</searchLink>; Institute of Macromolecular Chemistry of the Czech Academy of Sciences, Heyrovskeho namesti 1888, Prague 162 00, Czech Republic.<br /><searchLink fieldCode="AU" term="%22Subr+V%22">Subr V</searchLink>; Institute of Macromolecular Chemistry of the Czech Academy of Sciences, Heyrovskeho namesti 1888, Prague 162 00, Czech Republic.<br /><searchLink fieldCode="AU" term="%22Kovarova+J%22">Kovarova J</searchLink>; Institute of Microbiology of the Czech Academy of Sciences, Videnska 1083, Prague 142 00, Czech Republic.<br /><searchLink fieldCode="AU" term="%22Roubalova+R%22">Roubalova R</searchLink>; Institute of Microbiology of the Czech Academy of Sciences, Videnska 1083, Prague 142 00, Czech Republic.<br /><searchLink fieldCode="AU" term="%22Sirova+M%22">Sirova M</searchLink>; Institute of Microbiology of the Czech Academy of Sciences, Videnska 1083, Prague 142 00, Czech Republic.<br /><searchLink fieldCode="AU" term="%22Etrych+T%22">Etrych T</searchLink>; Institute of Macromolecular Chemistry of the Czech Academy of Sciences, Heyrovskeho namesti 1888, Prague 162 00, Czech Republic.<br /><searchLink fieldCode="AU" term="%22Kovar+M%22">Kovar M</searchLink>; Institute of Microbiology of the Czech Academy of Sciences, Videnska 1083, Prague 142 00, Czech Republic.
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  Data: <i>Publisher: </i><searchLink fieldCode="PB" term="%22American+Chemical+Society%22">American Chemical Society </searchLink><i>Country of Publication: </i>United States <i>NLM ID: </i>100892849 <i>Publication Model: </i>Print-Electronic <i>Cited Medium: </i>Internet <i>ISSN: </i>1526-4602 (Electronic) <i>Linking ISSN: </i><searchLink fieldCode="IS" term="%2215257797%22">15257797 </searchLink><i>NLM ISO Abbreviation: </i>Biomacromolecules <i>Subsets: </i>MEDLINE
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              Text: 2026 Feb 09
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