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Expanding the payload scope in antibody-drug conjugates by delivery of hydroxy-containing drugs through self-immolative phosphoramidates.

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Title: Expanding the payload scope in antibody-drug conjugates by delivery of hydroxy-containing drugs through self-immolative phosphoramidates.
Authors: Ochtrop P; Tubulis GmbH, IZB, Planegg-Martinsried, Germany., Jagtap AP; Tubulis GmbH, IZB, Planegg-Martinsried, Germany., Felber JG; Tubulis GmbH, IZB, Planegg-Martinsried, Germany., Vogt S; Tubulis GmbH, IZB, Planegg-Martinsried, Germany., Herterich S; Tubulis GmbH, IZB, Planegg-Martinsried, Germany., Mai I; Tubulis GmbH, IZB, Planegg-Martinsried, Germany., Cyprys P; Tubulis GmbH, IZB, Planegg-Martinsried, Germany., Schmitt S; Tubulis GmbH, IZB, Planegg-Martinsried, Germany., Payer S; Tubulis GmbH, IZB, Planegg-Martinsried, Germany., Kitowski A; Tubulis GmbH, IZB, Planegg-Martinsried, Germany., Wunder S; Tubulis GmbH, IZB, Planegg-Martinsried, Germany., Machui P; Tubulis GmbH, IZB, Planegg-Martinsried, Germany., Brandmeier J; Tubulis GmbH, IZB, Planegg-Martinsried, Germany., Leonardi N; Tubulis GmbH, IZB, Planegg-Martinsried, Germany., Poliak E; Tubulis GmbH, IZB, Planegg-Martinsried, Germany., Hackenberger CPR; Chemical Biology Department, Leibniz-Forschungsinstitut für Molekulare Pharmakologie (FMP), Berlin, Germany.; Department of Chemistry, Humboldt Universität zu Berlin, Berlin, Germany., Marcq O; Tubulis GmbH, IZB, Planegg-Martinsried, Germany., Schumacher D; Tubulis GmbH, IZB, Planegg-Martinsried, Germany., Helma J; Tubulis GmbH, IZB, Planegg-Martinsried, Germany., Vogl AM; Tubulis GmbH, IZB, Planegg-Martinsried, Germany., Kasper MA; Tubulis GmbH, IZB, Planegg-Martinsried, Germany. marc.kasper@tubulis.com.
Source: Nature communications [Nat Commun] 2026 Jan 20; Vol. 17 (1), pp. 759. Date of Electronic Publication: 2026 Jan 20.
Publication Type: Journal Article
Journal Info: Publisher: Nature Pub. Group Country of Publication: England NLM ID: 101528555 Publication Model: Electronic Cited Medium: Internet ISSN: 2041-1723 (Electronic) Linking ISSN: 20411723 NLM ISO Abbreviation: Nat Commun Subsets: MEDLINE
Database: MEDLINE Ultimate
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ISSN:2041-1723
DOI:10.1038/s41467-026-68605-y