SH3 domains selectively activate the PI3 kinase through non-conventional tertiary contacts.

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Title: SH3 domains selectively activate the PI3 kinase through non-conventional tertiary contacts.
Authors: Aljedani SS; Biological and Environmental Science and Engineering Division, KAUST Center of Excellence in Smart Health (KCSH), King Abdullah University of Science and Technology (KAUST), Thuwal, Saudi Arabia.; Infectious Disease Research Department, King Abdullah International Medical Research Center, Riyadh, Saudi Arabia.; King Saud bin Abdulaziz University for Health Science, Riyadh, Saudi Arabia., Sandholu A; Biological and Environmental Science and Engineering Division, KAUST Center of Excellence in Smart Health (KCSH), King Abdullah University of Science and Technology (KAUST), Thuwal, Saudi Arabia., Aldehaiman A; Biological and Environmental Science and Engineering Division, KAUST Center of Excellence in Smart Health (KCSH), King Abdullah University of Science and Technology (KAUST), Thuwal, Saudi Arabia., Alharbi S; Biological and Environmental Science and Engineering Division, KAUST Center of Excellence in Smart Health (KCSH), King Abdullah University of Science and Technology (KAUST), Thuwal, Saudi Arabia., Mak VCY; School of Biomedical Sciences, Li Ka Shing Faculty of Medicine, The University of Hong Kong, Hong Kong, China., Wu H; Department of Molecular Pharmacology, Albert Einstein College of Medicine, Bronx, NY, USA., Wang P; School of Biomedical Sciences, Li Ka Shing Faculty of Medicine, The University of Hong Kong, Hong Kong, China., Momin AA; Biological and Environmental Science and Engineering Division, KAUST Center of Excellence in Smart Health (KCSH), King Abdullah University of Science and Technology (KAUST), Thuwal, Saudi Arabia., Singh U; Biological and Environmental Science and Engineering Division, KAUST Center of Excellence in Smart Health (KCSH), King Abdullah University of Science and Technology (KAUST), Thuwal, Saudi Arabia., Lugari A; CRCM, CNRS, INSERM, Institut Paoli-Calmettes, Aix-Marseille University, Marseille, France.; Sartorius Canada Inc., Oakville, ON, Canada., Jaremko Ł; Biological and Environmental Science and Engineering Division, KAUST Center of Excellence in Smart Health (KCSH), King Abdullah University of Science and Technology (KAUST), Thuwal, Saudi Arabia.; Department of Biochemistry & Molecular Biology (BMB), Sealy Institute for Drug Discovery (SIDD), University of Texas Medical Branch (UTMB), Galveston, TX, 77555-1068, USA., Jaremko M; Biological and Environmental Science and Engineering Division, KAUST Center of Excellence in Smart Health (KCSH), King Abdullah University of Science and Technology (KAUST), Thuwal, Saudi Arabia.; The Golden Ratio Institute, Riyadh, 13244, Saudi Arabia., Morelli X; CRCM, CNRS, INSERM, Institut Paoli-Calmettes, Aix-Marseille University, Marseille, France., Backer JM; Department of Molecular Pharmacology, Albert Einstein College of Medicine, Bronx, NY, USA., Ladbury JE; School of Molecular and Cellular Biology, and Astbury Centre for Structural Molecular Biology, University of Leeds, Leeds, UK., Nowakowski M; Biological and Chemical Research Centre, Faculty of Chemistry, University of Warsaw, Warsaw, Poland., Cheung LWT; School of Biomedical Sciences, Li Ka Shing Faculty of Medicine, The University of Hong Kong, Hong Kong, China. lydiacwt@hku.hk., Arold ST; Biological and Environmental Science and Engineering Division, KAUST Center of Excellence in Smart Health (KCSH), King Abdullah University of Science and Technology (KAUST), Thuwal, Saudi Arabia. stefan.arold@kaust.edu.sa.
Source: Communications biology [Commun Biol] 2026 Jan 19; Vol. 9 (1). Date of Electronic Publication: 2026 Jan 19.
Publication Type: Journal Article
Journal Info: Publisher: Nature Publishing Group UK Country of Publication: England NLM ID: 101719179 Publication Model: Electronic Cited Medium: Internet ISSN: 2399-3642 (Electronic) Linking ISSN: 23993642 NLM ISO Abbreviation: Commun Biol Subsets: MEDLINE
Database: MEDLINE Ultimate
Description
ISSN:2399-3642
DOI:10.1038/s42003-026-09540-y