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SH3 domains selectively activate the PI3 kinase through non-conventional tertiary contacts.

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Title: SH3 domains selectively activate the PI3 kinase through non-conventional tertiary contacts.
Authors: Aljedani SS; Biological and Environmental Science and Engineering Division, KAUST Center of Excellence in Smart Health (KCSH), King Abdullah University of Science and Technology (KAUST), Thuwal, Saudi Arabia.; Infectious Disease Research Department, King Abdullah International Medical Research Center, Riyadh, Saudi Arabia.; King Saud bin Abdulaziz University for Health Science, Riyadh, Saudi Arabia., Sandholu A; Biological and Environmental Science and Engineering Division, KAUST Center of Excellence in Smart Health (KCSH), King Abdullah University of Science and Technology (KAUST), Thuwal, Saudi Arabia., Aldehaiman A; Biological and Environmental Science and Engineering Division, KAUST Center of Excellence in Smart Health (KCSH), King Abdullah University of Science and Technology (KAUST), Thuwal, Saudi Arabia., Alharbi S; Biological and Environmental Science and Engineering Division, KAUST Center of Excellence in Smart Health (KCSH), King Abdullah University of Science and Technology (KAUST), Thuwal, Saudi Arabia., Mak VCY; School of Biomedical Sciences, Li Ka Shing Faculty of Medicine, The University of Hong Kong, Hong Kong, China., Wu H; Department of Molecular Pharmacology, Albert Einstein College of Medicine, Bronx, NY, USA., Wang P; School of Biomedical Sciences, Li Ka Shing Faculty of Medicine, The University of Hong Kong, Hong Kong, China., Momin AA; Biological and Environmental Science and Engineering Division, KAUST Center of Excellence in Smart Health (KCSH), King Abdullah University of Science and Technology (KAUST), Thuwal, Saudi Arabia., Singh U; Biological and Environmental Science and Engineering Division, KAUST Center of Excellence in Smart Health (KCSH), King Abdullah University of Science and Technology (KAUST), Thuwal, Saudi Arabia., Lugari A; CRCM, CNRS, INSERM, Institut Paoli-Calmettes, Aix-Marseille University, Marseille, France.; Sartorius Canada Inc., Oakville, ON, Canada., Jaremko Ł; Biological and Environmental Science and Engineering Division, KAUST Center of Excellence in Smart Health (KCSH), King Abdullah University of Science and Technology (KAUST), Thuwal, Saudi Arabia.; Department of Biochemistry & Molecular Biology (BMB), Sealy Institute for Drug Discovery (SIDD), University of Texas Medical Branch (UTMB), Galveston, TX, 77555-1068, USA., Jaremko M; Biological and Environmental Science and Engineering Division, KAUST Center of Excellence in Smart Health (KCSH), King Abdullah University of Science and Technology (KAUST), Thuwal, Saudi Arabia.; The Golden Ratio Institute, Riyadh, 13244, Saudi Arabia., Morelli X; CRCM, CNRS, INSERM, Institut Paoli-Calmettes, Aix-Marseille University, Marseille, France., Backer JM; Department of Molecular Pharmacology, Albert Einstein College of Medicine, Bronx, NY, USA., Ladbury JE; School of Molecular and Cellular Biology, and Astbury Centre for Structural Molecular Biology, University of Leeds, Leeds, UK., Nowakowski M; Biological and Chemical Research Centre, Faculty of Chemistry, University of Warsaw, Warsaw, Poland., Cheung LWT; School of Biomedical Sciences, Li Ka Shing Faculty of Medicine, The University of Hong Kong, Hong Kong, China. lydiacwt@hku.hk., Arold ST; Biological and Environmental Science and Engineering Division, KAUST Center of Excellence in Smart Health (KCSH), King Abdullah University of Science and Technology (KAUST), Thuwal, Saudi Arabia. stefan.arold@kaust.edu.sa.
Source: Communications biology [Commun Biol] 2026 Jan 19; Vol. 9 (1). Date of Electronic Publication: 2026 Jan 19.
Publication Type: Journal Article
Journal Info: Publisher: Nature Publishing Group UK Country of Publication: England NLM ID: 101719179 Publication Model: Electronic Cited Medium: Internet ISSN: 2399-3642 (Electronic) Linking ISSN: 23993642 NLM ISO Abbreviation: Commun Biol Subsets: MEDLINE
Database: MEDLINE Ultimate
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  Data: SH3 domains selectively activate the PI3 kinase through non-conventional tertiary contacts.
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  Data: <searchLink fieldCode="AU" term="%22Aljedani+SS%22">Aljedani SS</searchLink>; Biological and Environmental Science and Engineering Division, KAUST Center of Excellence in Smart Health (KCSH), King Abdullah University of Science and Technology (KAUST), Thuwal, Saudi Arabia.; Infectious Disease Research Department, King Abdullah International Medical Research Center, Riyadh, Saudi Arabia.; King Saud bin Abdulaziz University for Health Science, Riyadh, Saudi Arabia.<br /><searchLink fieldCode="AU" term="%22Sandholu+A%22">Sandholu A</searchLink>; Biological and Environmental Science and Engineering Division, KAUST Center of Excellence in Smart Health (KCSH), King Abdullah University of Science and Technology (KAUST), Thuwal, Saudi Arabia.<br /><searchLink fieldCode="AU" term="%22Aldehaiman+A%22">Aldehaiman A</searchLink>; Biological and Environmental Science and Engineering Division, KAUST Center of Excellence in Smart Health (KCSH), King Abdullah University of Science and Technology (KAUST), Thuwal, Saudi Arabia.<br /><searchLink fieldCode="AU" term="%22Alharbi+S%22">Alharbi S</searchLink>; Biological and Environmental Science and Engineering Division, KAUST Center of Excellence in Smart Health (KCSH), King Abdullah University of Science and Technology (KAUST), Thuwal, Saudi Arabia.<br /><searchLink fieldCode="AU" term="%22Mak+VCY%22">Mak VCY</searchLink>; School of Biomedical Sciences, Li Ka Shing Faculty of Medicine, The University of Hong Kong, Hong Kong, China.<br /><searchLink fieldCode="AU" term="%22Wu+H%22">Wu H</searchLink>; Department of Molecular Pharmacology, Albert Einstein College of Medicine, Bronx, NY, USA.<br /><searchLink fieldCode="AU" term="%22Wang+P%22">Wang P</searchLink>; School of Biomedical Sciences, Li Ka Shing Faculty of Medicine, The University of Hong Kong, Hong Kong, China.<br /><searchLink fieldCode="AU" term="%22Momin+AA%22">Momin AA</searchLink>; Biological and Environmental Science and Engineering Division, KAUST Center of Excellence in Smart Health (KCSH), King Abdullah University of Science and Technology (KAUST), Thuwal, Saudi Arabia.<br /><searchLink fieldCode="AU" term="%22Singh+U%22">Singh U</searchLink>; Biological and Environmental Science and Engineering Division, KAUST Center of Excellence in Smart Health (KCSH), King Abdullah University of Science and Technology (KAUST), Thuwal, Saudi Arabia.<br /><searchLink fieldCode="AU" term="%22Lugari+A%22">Lugari A</searchLink>; CRCM, CNRS, INSERM, Institut Paoli-Calmettes, Aix-Marseille University, Marseille, France.; Sartorius Canada Inc., Oakville, ON, Canada.<br /><searchLink fieldCode="AU" term="%22Jaremko+Ł%22">Jaremko Ł</searchLink>; Biological and Environmental Science and Engineering Division, KAUST Center of Excellence in Smart Health (KCSH), King Abdullah University of Science and Technology (KAUST), Thuwal, Saudi Arabia.; Department of Biochemistry & Molecular Biology (BMB), Sealy Institute for Drug Discovery (SIDD), University of Texas Medical Branch (UTMB), Galveston, TX, 77555-1068, USA.<br /><searchLink fieldCode="AU" term="%22Jaremko+M%22">Jaremko M</searchLink>; Biological and Environmental Science and Engineering Division, KAUST Center of Excellence in Smart Health (KCSH), King Abdullah University of Science and Technology (KAUST), Thuwal, Saudi Arabia.; The Golden Ratio Institute, Riyadh, 13244, Saudi Arabia.<br /><searchLink fieldCode="AU" term="%22Morelli+X%22">Morelli X</searchLink>; CRCM, CNRS, INSERM, Institut Paoli-Calmettes, Aix-Marseille University, Marseille, France.<br /><searchLink fieldCode="AU" term="%22Backer+JM%22">Backer JM</searchLink>; Department of Molecular Pharmacology, Albert Einstein College of Medicine, Bronx, NY, USA.<br /><searchLink fieldCode="AU" term="%22Ladbury+JE%22">Ladbury JE</searchLink>; School of Molecular and Cellular Biology, and Astbury Centre for Structural Molecular Biology, University of Leeds, Leeds, UK.<br /><searchLink fieldCode="AU" term="%22Nowakowski+M%22">Nowakowski M</searchLink>; Biological and Chemical Research Centre, Faculty of Chemistry, University of Warsaw, Warsaw, Poland.<br /><searchLink fieldCode="AU" term="%22Cheung+LWT%22">Cheung LWT</searchLink>; School of Biomedical Sciences, Li Ka Shing Faculty of Medicine, The University of Hong Kong, Hong Kong, China. lydiacwt@hku.hk.<br /><searchLink fieldCode="AU" term="%22Arold+ST%22">Arold ST</searchLink>; Biological and Environmental Science and Engineering Division, KAUST Center of Excellence in Smart Health (KCSH), King Abdullah University of Science and Technology (KAUST), Thuwal, Saudi Arabia. stefan.arold@kaust.edu.sa.
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  Data: <searchLink fieldCode="JN" term="%22101719179%22">Communications biology</searchLink> [Commun Biol] 2026 Jan 19; Vol. 9 (1). <i>Date of Electronic Publication: </i>2026 Jan 19.
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