Rational Design of Enzyme-Responsive Fluorescent Organoruthenium Prodrug for Real-Time Tracking of Cargo Release and Cytotoxicity.

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Title: Rational Design of Enzyme-Responsive Fluorescent Organoruthenium Prodrug for Real-Time Tracking of Cargo Release and Cytotoxicity.
Authors: Sugantharam K; Department of Chemistry, SRM Institute of Science and Technology, Kattankulathur, Tamil Nadu 603 203, India., Ramu V; Faculty of Chemistry and Biochemistry, Chair of Inorganic Chemistry I - Bioinorganic Chemistry, Ruhr University Bochum, Universitätsstraße 150, Bochum 44801, Germany., Sumithaa C; Department of Chemistry, SRM Institute of Science and Technology, Kattankulathur, Tamil Nadu 603 203, India., Karanath-Anilkumar A; Molecular Biology and Immunobiology Division, Interdisciplinary Institute of Indian System of Medicine, SRM Institute of Science and Technology, Kattankulathur, Tamil Nadu 603 203, India.; Department of Biotechnology, Faculty of Engineering and Technology, SRM Institute of Science and Technology, Kattankulathur, Tamil Nadu 603 203, India., Munuswamy-Ramanujam G; Department of Chemistry, SRM Institute of Science and Technology, Kattankulathur, Tamil Nadu 603 203, India.; Molecular Biology and Immunobiology Division, Interdisciplinary Institute of Indian System of Medicine, SRM Institute of Science and Technology, Kattankulathur, Tamil Nadu 603 203, India., Bhuvanesh N; X-ray Diffraction Lab, Department of Chemistry, Texas A&M University, College Station, Texas 77842, United States., Metzler-Nolte N; Faculty of Chemistry and Biochemistry, Chair of Inorganic Chemistry I - Bioinorganic Chemistry, Ruhr University Bochum, Universitätsstraße 150, Bochum 44801, Germany., Ganeshpandian M; Department of Chemistry, SRM Institute of Science and Technology, Kattankulathur, Tamil Nadu 603 203, India.
Source: Inorganic chemistry [Inorg Chem] 2026 Jun 01; Vol. 65 (21), pp. 11562-11576. Date of Electronic Publication: 2026 Jan 20.
Publication Type: Journal Article
Journal Info: Publisher: American Chemical Society Country of Publication: United States NLM ID: 0366543 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1520-510X (Electronic) Linking ISSN: 00201669 NLM ISO Abbreviation: Inorg Chem Subsets: MEDLINE
Database: MEDLINE Ultimate
Description
ISSN:1520-510X
DOI:10.1021/acs.inorgchem.5c04797