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Rational Design of Enzyme-Responsive Fluorescent Organoruthenium Prodrug for Real-Time Tracking of Cargo Release and Cytotoxicity.

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Title: Rational Design of Enzyme-Responsive Fluorescent Organoruthenium Prodrug for Real-Time Tracking of Cargo Release and Cytotoxicity.
Authors: Sugantharam K; Department of Chemistry, SRM Institute of Science and Technology, Kattankulathur, Tamil Nadu 603 203, India., Ramu V; Faculty of Chemistry and Biochemistry, Chair of Inorganic Chemistry I - Bioinorganic Chemistry, Ruhr University Bochum, Universitätsstraße 150, Bochum 44801, Germany., Sumithaa C; Department of Chemistry, SRM Institute of Science and Technology, Kattankulathur, Tamil Nadu 603 203, India., Karanath-Anilkumar A; Molecular Biology and Immunobiology Division, Interdisciplinary Institute of Indian System of Medicine, SRM Institute of Science and Technology, Kattankulathur, Tamil Nadu 603 203, India.; Department of Biotechnology, Faculty of Engineering and Technology, SRM Institute of Science and Technology, Kattankulathur, Tamil Nadu 603 203, India., Munuswamy-Ramanujam G; Department of Chemistry, SRM Institute of Science and Technology, Kattankulathur, Tamil Nadu 603 203, India.; Molecular Biology and Immunobiology Division, Interdisciplinary Institute of Indian System of Medicine, SRM Institute of Science and Technology, Kattankulathur, Tamil Nadu 603 203, India., Bhuvanesh N; X-ray Diffraction Lab, Department of Chemistry, Texas A&M University, College Station, Texas 77842, United States., Metzler-Nolte N; Faculty of Chemistry and Biochemistry, Chair of Inorganic Chemistry I - Bioinorganic Chemistry, Ruhr University Bochum, Universitätsstraße 150, Bochum 44801, Germany., Ganeshpandian M; Department of Chemistry, SRM Institute of Science and Technology, Kattankulathur, Tamil Nadu 603 203, India.
Source: Inorganic chemistry [Inorg Chem] 2026 Jun 01; Vol. 65 (21), pp. 11562-11576. Date of Electronic Publication: 2026 Jan 20.
Publication Type: Journal Article
Journal Info: Publisher: American Chemical Society Country of Publication: United States NLM ID: 0366543 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1520-510X (Electronic) Linking ISSN: 00201669 NLM ISO Abbreviation: Inorg Chem Subsets: MEDLINE
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  Data: Rational Design of Enzyme-Responsive Fluorescent Organoruthenium Prodrug for Real-Time Tracking of Cargo Release and Cytotoxicity.
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  Data: <searchLink fieldCode="AU" term="%22Sugantharam+K%22">Sugantharam K</searchLink>; Department of Chemistry, SRM Institute of Science and Technology, Kattankulathur, Tamil Nadu 603 203, India.<br /><searchLink fieldCode="AU" term="%22Ramu+V%22">Ramu V</searchLink>; Faculty of Chemistry and Biochemistry, Chair of Inorganic Chemistry I - Bioinorganic Chemistry, Ruhr University Bochum, Universitätsstraße 150, Bochum 44801, Germany.<br /><searchLink fieldCode="AU" term="%22Sumithaa+C%22">Sumithaa C</searchLink>; Department of Chemistry, SRM Institute of Science and Technology, Kattankulathur, Tamil Nadu 603 203, India.<br /><searchLink fieldCode="AU" term="%22Karanath-Anilkumar+A%22">Karanath-Anilkumar A</searchLink>; Molecular Biology and Immunobiology Division, Interdisciplinary Institute of Indian System of Medicine, SRM Institute of Science and Technology, Kattankulathur, Tamil Nadu 603 203, India.; Department of Biotechnology, Faculty of Engineering and Technology, SRM Institute of Science and Technology, Kattankulathur, Tamil Nadu 603 203, India.<br /><searchLink fieldCode="AU" term="%22Munuswamy-Ramanujam+G%22">Munuswamy-Ramanujam G</searchLink>; Department of Chemistry, SRM Institute of Science and Technology, Kattankulathur, Tamil Nadu 603 203, India.; Molecular Biology and Immunobiology Division, Interdisciplinary Institute of Indian System of Medicine, SRM Institute of Science and Technology, Kattankulathur, Tamil Nadu 603 203, India.<br /><searchLink fieldCode="AU" term="%22Bhuvanesh+N%22">Bhuvanesh N</searchLink>; X-ray Diffraction Lab, Department of Chemistry, Texas A&M University, College Station, Texas 77842, United States.<br /><searchLink fieldCode="AU" term="%22Metzler-Nolte+N%22">Metzler-Nolte N</searchLink>; Faculty of Chemistry and Biochemistry, Chair of Inorganic Chemistry I - Bioinorganic Chemistry, Ruhr University Bochum, Universitätsstraße 150, Bochum 44801, Germany.<br /><searchLink fieldCode="AU" term="%22Ganeshpandian+M%22">Ganeshpandian M</searchLink>; Department of Chemistry, SRM Institute of Science and Technology, Kattankulathur, Tamil Nadu 603 203, India.
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  Data: <searchLink fieldCode="JN" term="%220366543%22">Inorganic chemistry</searchLink> [Inorg Chem] 2026 Jun 01; Vol. 65 (21), pp. 11562-11576. <i>Date of Electronic Publication: </i>2026 Jan 20.
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              Text: 2026 Jun 01
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